后基因时代神经源性疼痛研究的焦点：蛋白质网络

后基因时代到来后蛋白质组学技术得到了迅猛发展,系统化和网络化研究神经源性疼痛模型中,神经系统蛋白质结构和功能必将是未来疼痛相关研究的重要组成部分。蛋白质组学方法的广泛应用,将为我们提供一个用于判断疼痛的新工具,更有利于疼痛机理的揭示。     

Queuing or sharing? A critical evaluation of the single-bottleneck notion

The model of a single central bottleneck for human information processing is critically examined. Most evidence cited in support of the model has been observed within the overlapping tasks paradigm. It is shown here that most findings obtained within that paradigm and that were used to support the model are also consistent with a simple resource model. The most prominent findings are the millisecond-for-millisecond slope at the left of the RT2-SOA curve, the high RT1-RT2 correlation, the additivity of the effects on RT2 of SOA and of the difficulty of selecting R2, and the washout of the effect of S2 discriminability on RT2 in a dual-task condition. In addition, the asymmetry of the effects of the dual-task requirement on RT1 and RT2 can be accounted for by the resource model provided that it assumes uneven allocation of resources, which is quite reasonable in view of the task asymmetry inherent in the demand characteristics of the paradigm. The same is true for two other findings that appear to support the single-bottleneck model-that in the dual-task condition, the demand of the first task affects equally RT1 and RT2 and that its effect on RT1 is the same as the corresponding effect in the single-task condition. Furthermore, the single-bottleneck model is hard to reconcile with a negative slope at the left of the RT1-SOA curve or a positive slope at the left of the IRI-SOA curve, unless augmented by ancillary assumptions that are yet to be substantiated. Representative data were fit by each of the models using its optimal set of parameters. Both models achieved quite good degrees of fit. It is further argued that since the overlapping tasks paradigm is heavily biased in favor of a speedy reaction to the stimulus that appears first, it is nonoptimal for testing the central bottleneck model. Finally, the bottleneck model is examined in terms of other scientific criteria.     

《齐物论》与竹林玄学

《庄子》作为“三玄”之一,在魏晋玄学中大行其道。阮籍和嵇康是两位在任自然的旗帜下发挥庄子思想的名士。分析发现,阮籍对庄子的理解,大致来自《齐物论》。然《齐物论》对他的意义是双重的：既排遣其对现实的不满,又给因对现实的无能为力而游戏人生的生活态度提供掩饰。嵇康学理上的表现在于,其“声无哀乐”的见解,以乐论的形式,对《齐物论》中齐是非的观点作独特的补充,同时,却又在讨论人格的公（诚）私（伪）之分时,把它同是非问题联系起来,从而显露自己无法掩饰的价值立场。阮、嵇无论是言还是行的矛盾,都与庄子齐是非的悖论有关。     

部分日本室町写本《周易》的宋刻唐写融合特征

日本室町时代(1393—1573)部分写本《周易》既有宋刊本特征,又有唐写本的异文,是一种融合了宋刊本与唐写本的特殊文本。此类文本今时日本早稻田大学、内阁文库各有一本。杨守敬日本访书时亦曾据此类文本影抄一部。根据校勘,《七经孟子考文》记载的足利学校所藏三种古本《周易》与此类文本大体相似。江户时代(1603—1867),这类特殊的《周易》写本过渡到刊本形态,刊本当中包括《七经孟子考文》所引足利本《周易》,以及东洋文化研究所藏活字本《周易》。     

Psychological refractory period in introverts and extraverts

The present study was designed to explore extraversion-related differences in the psychological refractory period (PRP). PRP refers to a bottleneck of information processing that becomes evident when participants are required to respond to two signals (S1 and S2) presented in rapid succession. If this capacity limit of premotor information processing is essential for differences in speed of information processing between introverts and extraverts, magnitude of the PRP effect should vary as a function of extraversion. Due to the failure of previous attempts to establish extraversion-related differences in the PRP effect, we also obtained lateralized readiness potentials (LRPs). For this purpose, 63 introverted and 63 extraverted female participants were tested with a standard PRP design. Extraverts responded faster to S2 and exhibited shorter stimulus-locked LRP latencies compared to introverts. Although a general PRP effect could be shown at the behavioral and psychophysiological level, there was no indication for any extraversion-related differences in PRP. Thus, extraversion-related differences in speed of information processing at the premotor level appear unlikely to originate from individual differences in the capacity limits underlying the PRP phenomenon. Furthermore, our findings provide converging evidence for the notion that extraversion-related individual differences in processing speed depend on specific task demands.     

Visual working memory for trained and novel polygons

This study investigates whether training changes the capacity of visual working memory (VWM). We compared change detection performance for novel and trained polygons. During training, subjects developed familiarity with 8 random polygons. Specifically, 4 polygons from a set of 8 were presented on each trial. After a brief retention interval, one of the polygons changed and subjects judged which one had changed (Exps. 1–2) or whether there was a change (Exp. 3). After 320 training trials, subjects could recognize the trained polygons with high accuracy. In the testing phase, subjects carried out the same task again, only this time each trial might contain all familiar polygons, all novel polygons, or a mixture of familiar and novel polygons. We found that change detection performance improved during training, but the improvement was not limited to trained polygons. We suggest that familiarity of non-nameable shapes plays a limited role in modulating the capacity of VWM.     

Intergenerational Religious Mobility in Contemporary China

This study illustrates intergenerational religious mobility with the case of Chinese society. Using the quasi‐symmetric log‐linear model to separate structure mobility from exchange mobility, we examine the variation in religious identities between the reform era generation and their parents. Structure mobility results suggest that the encompassing social reform over the past decades in China has encouraged the structural growth of Islam and Christianity across generations, but traditional Chinese religions bear remarkable intergenerational disadvantages. Moreover, religious nones are growing across generations, at least relative to traditional Chinese religions. Exchange mobility findings indicate that individuals whose parents follow traditional Chinese religions are very likely to “convert” to Christianity. However, children of religious nones do not necessarily remain irreligious, possibly undermining the structural advantages of religious nones in the future. Finally, a comparison between cohort and period effects drives us to conclude that the major social force underpinning the revival of Chinese religion in the reform era is generational replacement instead of an increasingly religious transition of “old” generations.     

Maternal avoidance,anxiety cognitions and interactive behaviour predicts infant development at 12 months in the context of anxiety disorders in the postpartum period

BackgroundFew studies have examined the relation between anxiety disorders in the postpartum period and cognitive as well as language development in infancy.AimsThis longitudinal study investigated whether anxiety disorder in the postpartum period is linked to infant development at twelve months. A closer look was also taken at a possible link between maternal interaction and infant development.Study designSubjects were videotaped during a Face-to-Face-Still-Face interaction with their infant (M = 4.0 months). Specific maternal anxiety symptoms were measured by self-report questionnaires (Anxiety Cognition Questionnaire (ACQ), Body Sensations Questionnaire (BSQ), Mobility Inventory (MI)) to check for a connection with infant development. The Bayley Scales of Infant and Toddler Development-III (Bayley-III) were used to assess infant language and cognitive development at one year of age.Subjectsn = 34 mothers with anxiety disorder (SCID-I; DSM-IV) and n = 47 healthy mothers with their infant.Outcome measuresInfant performance on Bayley-III language and cognitive scales.ResultsInfants of mothers with anxiety disorder yielded significantly lower language scores than infants of controls. No significant group differences were found regarding infant cognitive development. Exploratory analyses revealed the vital role of “maternal avoidance accompanied” in infant language and cognitive development. Maternal neutral engagement, which lacks positive affect and vocalisations, turned out as the strongest negative predictor of cognitive development. Maternal anxiety cognitions and joint activity in mother-infant interaction were the strongest predictors of infant language performance.ConclusionsResults underline the importance to also consider the interaction behaviour of women with anxiety disorders to prevent adverse infant development.     

Age of acquisition effects on the functional organization of language in the adult brain

Using functional magnetic resonance imaging (fMRI), we neuroimaged deaf adults as they performed two linguistic tasks with sentences in American Sign Language, grammatical judgment and phonemic-hand judgment. Participants’ age-onset of sign language acquisition ranged from birth to 14 years; length of sign language experience was substantial and did not vary in relation to age of acquisition. For both tasks, a more left lateralized pattern of activation was observed, with activity for grammatical judgment being more anterior than that observed for phonemic-hand judgment, which was more posterior by comparison. Age of acquisition was linearly and negatively related to activation levels in anterior language regions and positively related to activation levels in posterior visual regions for both tasks.     

重型颅脑损伤围术期亚低温治疗路径——循证医学指导下的治疗抉择

早期动物实验研究表明亚低温能减轻脑损伤后的继发性损害,促进神经功能恢复,然而对其临床疗效不同研究结果不完全一致。本文应用循证医学思想,检索和评价国内外文献,为重型颅脑损伤患者制定了围术期亚低温实施方案。随访结果表明,亚低温可改善患者预后。