高渗氯化钠羟乙基淀粉40注射液对肝肿瘤并高血压患者硬膜外复合全身麻醉诱导期的脑保护作用

观察预注高渗氯化钠羟乙基淀粉40注射液对肝肿瘤合并高血压患者硬膜外复合全身麻醉诱导期的脑保护作用。选择50例患有高血压ASA分级Ⅱ级～Ⅲ级肝肿瘤手术患者,随机分为高渗氯化钠羟乙基淀粉40注射液(H)组和复方氯化钠(复方乳酸林格液R)组,每组25例。于输注前(T0)、输注完毕即刻(T1)、气管插管后即刻(T2)、气管插管后5min(T3)、气管插管后15min(T4)、气管插管后30min(T5)抽取静脉血离心后检测血清中S100B、IL-6、TNF-a的浓度。与T0点相比,H组,T5点S100B轻度降低但无统计学差异(P0.05),IL-6、TNF-a无明显变化(P0.05);R组在T5点S100B明显上升(P0.01);IL-6、TNF-a明显上升(P0.05或P0.01)。与R组相比,H组患者在T3-5时点S100B、IL-6和TNF-a均低(P0.05或P0.01)。结论为预注高渗氯化钠羟乙基淀粉40注射液在肝肿瘤合并高血压患者硬膜外复合全身麻醉诱导期具有脑保护作用。     

老年髋部骨折围手术期医疗风险的分析与对策

髋部骨折是老年人的常见病之一,髋部骨折对老年人生命的危害最大。随着人口老龄化,老年髋部骨折发病率呈逐年上升趋势。老年骨质疏松髋部骨折围手术期的医疗风险临床较常见,如何降低老年骨质疏松髋部骨折围手术期的医疗风险,是临床骨科需要解决的问题。分析存在的风险问题,明确各种风险因素,尽可能降低老年髋部围手术期的医疗风险。     

酝酿期有效提示和无效提示的比较

采用中国汉字谜,通过模拟wallas(1926)关于顿悟问题解决的四个阶段,探讨了酝酿期有效提示和无效提示对猜字谜的影响。结果发现：有效提示组被试比无效提示组猜对了更多的靶字谜,反应时也更短;在脑电水平上,酝酿期的有效提示谜比无效提示谜在左前额叶分别于300ms-400ms,400ms-600ms,600ms-800ms内引发了更大的P300-400成分、P400-600成分、P600-800成分。表明有效提示谜比无效提示谜对靶字谜问题的解决有更大促进作用。     

汉末思想嬗变对《伤寒杂病论》的影响

汉末是两汉经学向魏晋玄学过渡的时期,有清通简要、得意忘言、务实求真等时代特点,并在一定程度上摆脱了神仙之风对医学的影响。从思想嬗变的角度,对中医巨著《伤寒杂病论》的行文风格、方法原则、学术思想等诸方面进行分析,从而提出对其时代背景研究的新思路。     

战国楚竹书《周易·字》卦"字"字考

本文通过对上海博物馆藏战国楚竹书《周易·字》卦卦名与爻辞中之“字”字的考释,证明传世本(周易·需)卦卦名与爻辞中之“需”字的原始意义,同《易传·序卦》所言“物稚不可不养也,故受之以需”较为接近,其要义为怀柔养善;马王堆汉墓帛书《六十四卦》之《襦》卦的“襦”字与马王堆汉墓帛书佚文《易之义》的《襦》卦之“嬬”字,均为“需”的通假字,而“需”字的形与义不是卦画之象所为。     

"儒"的自我理解——荀子说儒的意义

No matter what the original meaning of “Ru” was, looking at it from the perspective of the history of philosophy, the image of “Ru” as portrayed by other schools in the Warring States period was infused with the characteristics of Confucianism of that time. The self-understanding of Warring States Confucians expressed by their employment of the character “Ru” clearly displayed Ru’s character as well as the main points of the Ru school, namely Confucianism. In particular, the words and thoughts of Xunzi, the great Confucian master, on “Ru”, epitomize Pre-Qin Confucian’s understanding and expectations of themselves, and also reflect the Confucian new pursuit in facing the age of the unification of Qin. Translated by Yan Xin from Beijing daxue xuebao 北京大学学报 (Journal of Peking University), 2007, (5): 19–26     

On the optimality of serial and parallel processing in the psychological refractory period paradigm: Effects of the distribution of stimulus onset asynchronies

Within the context of the psychological refractory period (PRP) paradigm, we developed a general theoretical framework for deciding when it is more efficient to process two tasks in serial and when it is more efficient to process them in parallel. This analysis suggests that a serial mode is more efficient than a parallel mode under a wide variety of conditions and thereby suggests that ubiquitous evidence of serial processing in PRP tasks could result from performance optimization rather than from a structural bottleneck. The analysis further suggests that the experimenter-selected distribution of stimulus onset asynchronies (SOAs) influences the relative efficiency of the serial and parallel modes, with a preponderance of short SOAs favoring a parallel mode. Experiments varying the distribution of SOAs were conducted, and the results suggest that there is a shift from a more serial mode to a more parallel mode as the likelihood of short SOAs increases.     

Experiencing and regulating sadness: Physiological and cognitive effects

No prior study has examined the two most prominent response-focused regulation strategies (suppression and exaggeration) using a within-subjects design. Utilizing this design allows for a direct comparison of physiological patterns and cognitive impairment associated with such efforts. One hundred and nine participants were asked to view a series of three films, each preceded by a 10-second instructional slide which indicated the regulation strategy they were to perform (natural-watch, exaggerate, or suppress). Exaggeration was associated with increased sympathetic activation as indicated by an increase in galvanic skin conductance level (GSL) and shortened pre-ejection period (PEP). Suppression, much like the natural-watch condition, was associated with greater sympathetic withdrawal (i.e., decreased GSL, longer PEP). Both suppression and exaggeration led to reduced memory for the emotional movie, with exaggeration causing more impairment than suppression. Results suggest that exaggeration and suppression not only have very different behavioral manifestations, but physiological outcomes as well when utilized during a sad context.     

Object knowledge and the emergence of language

Infants' spontaneous play with objects was examined for evidence of developments in object knowledge in relation to the emergence of words and the single-word period in language development. Subjects were 7 girls and 7 boys, from different ethnic and economic backgrounds, who were studied longitudinally from 9 months to 26 months of age. Two types of displacements of objects in relation to one another were identified in the children's play: separations and constructions. The development of constructions was associated with the emergence of words, and constructions increased with age while separations decreased. The development of specific constructions, which account for knowledge of the particular properties of objects, was more strongly associated with a vocabulary spurt at the end of the single-word period than with chronological age. Despite the wide variation in the infants' ages when developments in language and play were reached, relations between achievements in the two domains were consistent among them, as confirmed with the Friedman test, p<.001. The results are discussed in terms of the cognitive developments required for play with objects and saying words.     

Implicit achievement motive limits the impact of task difficulty on effort-related cardiovascular response

In contrast to the motive literature, motivational intensity theory predicts that the implicit achievement motive (nAch) should only exert an indirect impact on effort by limiting the impact of task difficulty. To contrast these two views, sixty-eight participants with a low or high nAch performed an easy or difficult arithmetic task. Effort was assessed using cardiac pre-ejection period (PEP). Supporting motivational intensity theory’s view, PEP response was low in both easy-task conditions but stronger in the high-nAch group than in the low-nAch group in the difficult task. These findings suggest that nAch exerts an indirect effect on effort investment by setting the maximally justified effort instead of directly determining the amount of effort that is invested to satisfy the motive.