Episodic memory effects of gamma frequency precuneus transcranial magnetic stimulation in Alzheimer's disease: A randomized multiple baseline study

Episodic memory decline is the prominent neuropsychological feature of typical Alzheimer's Disease (AD), for which current treatments have a limited clinical response. Recently, gamma entrainment therapy has been used as a non-invasive treatment in AD, providing evidence that it may have the potential to alleviate brain pathology and improve cognitive function in AD patients. At the same time, the precuneus (PC) has been recognized as a key area involved in AD related memory deficits and as a key node of the Default Mode Network. This study aimed to investigate the effectiveness of a 40 Hz Transcranial Magnetic Stimulation (TMS) intervention, delivered bilaterally to the precuneus for 10 days, in improving the patients' episodic memory performance. Secondary outcome variables investigated included general cognitive function, semantic and spatial memory, as well as attention and executive function. A concurrent multiple baseline design across five cases was employed. Four patients completed the study. Visual analysis combined with effect size indices were used to evaluate changes across phases. An increase in the average level of immediate recalled words was observed in three out of four patients. Effect size indices indicated significant improvement of attention skills in two patients. No treatment effect was observed for semantic and visual memory, or for executive function. An immediate treatment effect was observed in all patients' general cognitive function as assessed with the Alzheimer's Disease Assessment Scale (mean reduction of 5 points), which was maintained and improved further three months post-treatment. The neuropsychological evaluations indicated improved performance three months post-treatment in immediate and delayed recall, attention, phonological verbal fluency, anxiety, and neuropsychiatric symptoms. This study provides preliminary evidence for the efficacy of a novel non-pharmacological treatment using gamma-band TMS in addressing cognitive dysfunction in AD.     

Lifespan normative data (18–89 years) for Raven's Advanced Progressive Matrices Set I

Raven's Advanced Progressive Matrices (APM) Set I is a validated and brief test of fluid intelligence, ideal for use in busy clinical settings. However, there is a dearth of normative data allowing an accurate interpretation of APM scores. To address this, we present normative data from across the adult lifespan (18–89 years) for the APM Set I. Data are presented in five age cohorts (total N = 352), including two older adult cohorts (65–79 years and 80–89 years), which allows age-standardized assessment. We also present data from a validated measure of premorbid intellectual ability, which was absent from previous standardizations of longer forms of the APM. In line with previous findings, a striking age-related decline was noted, beginning relatively early in adulthood and most marked amongst lower-scoring individuals. Older adults did not demonstrate difficulty with specific test items or make an increased proportion of specific errors. Sex was not a significant predictor of performance. The data set is of particular use in the neuropsychological assessment of older adults, given the known susceptibility of fluid intelligence to both the effects of normal ageing and acquired brain injury in older age. The results are discussed in light of theories of neurological ageing.     

HOW DOES THE TEILHARDIAN VISION OF EVOLUTION COMPARE WITH CONTEMPORARY THEORIES?

Abstract. Teilhard de Chardin's ideas about the mechanisms of biological evolution are revised and their connections with contemporary theories are reported. Teilhard de Chardin's main contribution is the proposal of a new scientific discipline, geobiology—the science of the biosphere evolving as a whole. The main fields of interest of geobiology are reported, and its relationships with contemporary hypotheses, such as Lovelock's Gaia, are discussed. The consequences of this kind of approach are the parallel evolution described as orthogenesis and the presence of canalization phenomena. These Teilhardian hypotheses are discussed in relation to those of the process structuralists and to the novelties of the molecular evolution of the genome. Conclusions are that the mechanisms discussed by Teilhard are presently taken into consideration by contemporary evolutionists in order to construct a new theory of biological evolution.     

AN EXPLOSION OF DAZZLING FLASHES: TEILHARD'S UNITY OF FAITH AND SCIENCE

Abstract. Science and revelation have been presented as two books with the same “author,” their reconciliation being called “concordism.” Teilhard opposed concordism, insisting that supposed “revelations” be treated as scientific hypotheses to be verified or not in experience. Applying his criterion for truth (Does it bring “coherence and fecundity” to the phenomena?) to Christian revelation, he told of finding “an explosion of dazzling flashes.” So Teilhard spoke of the hypothesis as the supreme spiritual act wherein the dust of experience takes on form and is kindled at the fire of knowledge.     

ACHIEVING AND MAINTAINING COMPLIANCE WITH THE KETOGENIC DIET

The ketogenic diet, a treatment for intractable epilepsy, is rarely initiated because it requires strict compliance with a diet that is perceived to be unpalatable. In a case study of a 15-year-old girl with uncontrolled epilepsy, we used a stimulus-choice procedure to assess relative preferences of 33 foods from the diet and to develop two treatments based on Premack's principle. The results of a multielement analysis showed that both treatments increased dietary compliance. Compliance was maintained with generalization of treatment across settings, and was associated with a 40% reduction in seizures.     

Marcel's “availability” in existential psychotherapy with couples and families

Gabriel Marcel was a French, Catholic, existential philosopher who first presented the concept of human availability as a central way of strengthening the self and facilitating the experience of human freedom. In this article Marcel's ideas about availability are described, reviewed, and examined for their implications for the practice of existential psychotherapy with couples and families.     

SEQUENTIAL APPLICATION OF MAJOR HABIT-REVERSAL COMPONENTS TO TREAT MOTOR TICS IN CHILDREN

In this study, we sequentially administered up to four components of the habit-reversal treatment to 4 children with motor tics within a multiple baseline design. The habit-reversal components included (a) awareness training; (b) awareness training and self-monitoring; (c) awareness training, self-monitoring, and social support; and (d) awareness training, social support, and the use of a competing response. Results demonstrated that the combined use of awareness training, social support, and competing response training was effective in eliminating motor tics in 2 of 4 children, that awareness training alone was effective for 1 child, and that a combination of awareness training and self-monitoring was effective for the 4th child. The treatment and ensuing improvement were found to be socially valid. We discuss possible explanations for these results and recommend directions for future research.     

On optimal smoothing and derivative estimation from noisy displacement data in biomechanics

Estimating derivatives from noisy displacement data is a notoriously ill-posed problem in signal processing and biomechanics. Following the work of Wood and Jennings (1978) and Hatze (1979, 1981), the present paper describes the use of optimally regularized, natural quintic splines for estimating smoothed positions, velocities, and accelerations from equidistantly sampled, noisy position measurements. It appears that the nature of the boundary conditions of the data is of some importance, since various algorithms used hitherto result in artefacts throughout the data if the true derivatives at the record ends differ significantly from zero. Natural quintic splines do not suffer from this disadvantage below the third derivative.The ill-posed character of movement analysis has some interesting implications for movement synthesis and optimization, similar to the indeterminacy of muscular co-contraction from merely external, biomechanical measurements.