免疫性疾病治疗新途径：诱导细胞程序性死亡

免疫性疾病是一大类难治性的免疫紊乱而造成的疾病,尤其是自身免疫性疾病的一直困扰着免疫学家。传统的免疫治疗是根据不同疾病的需要增强免疫,调节免疫和抑制的方式进行,以辩证的观点分析免疫的增殖与程序性死亡这一对矛盾,认为：免疫性疾病的本质是免疫细胞增殖与程序性恨的失衡,因而通过诱导免疫细胞程序性死亡将成为免疫治疗的新途径。     

Exploratory Eye Movements to Pictures in Childhood-Onset Schizophrenia and Attention-Deficit/Hyperactivity Disorder (ADHD)

We investigated exploratory eye movements to thematic pictures in schizophrenic, attention-deficit/hyperactivity disorder (ADHD), and normal children. For each picture, children were asked three questions varying in amount of structure. We tested if schizophrenic children would stare or scan extensively and if their scan patterns were differentially affected by the question. Time spent viewing relevant and irrelevant regions, fixation duration (an estimate of processing rate), and distance between fixations (an estimate of breadth of attention) were measured. ADHD children showed a trend toward shorter fixations than normals on the question requiring the most detailed analysis. Schizophrenic children looked at fewer relevant, but not more irrelevant, regions than normals. They showed a tendency to stare more when asked to decide what was happening but not when asked to attend to specific regions. Thus, lower levels of visual attention (e.g., basic control of eye movements) were intact in schizophrenic children. In contrast, they had difficulty with top-down control of selective attention in the service of self-guided behavior.     

The Behavioral and Emotional Rating Scale: Test-Retest and Inter-Rater Reliability

Two studies are reported addressing the reliability of the Behavioral and Emotional Rating Scale (BERS). The first study investigated test-retest reliability over a two-week period to determine the stability of the measure over time. The second study investigated inter-rater reliability between two teachers or classroom aides who were familiar with a student to determine the consistency with which the measure can be used by different individuals. In each study, samples were drawn from populations of students identified with emotional or behavioral disorders as specified by federal statutes. Reliability coefficients in each study were above .80, the standard recommended for screening tests that are reported individually, and in most cases above .90. Implications for use of the BERS are discussed.     

Engagement in Child and Adolescent Treatment: The Role of Parental Cognitions and Attributions

Parental engagement in the treatment process is influenced by parents' beliefs about the cause of their children's problems, perceptions about their ability to handle such problems, and expectations about the ability of therapy to help them. This paper examines the role of parental cognitions related to attributions and expectations in relation to engagement in child mental health treatment. Reviewed studies indicate that parental attributions and expectations influence three aspects of treatment: help seeking, engagement and retention, and outcome. This paper integrates findings from developmental and clinical research, highlights gaps in the literature, presents the beginnings of a model regarding the parental attributional process as it relates to engagement in treatment, recommends future research directions, and discusses clinical implications.     

Making Decisions About Life-Sustaining Medical Treatment in Patients With Dementia

The problem of decision-making capacity in patients with dementia, such as those with early stage Alzheimer's, can be vexing, especially when these patients refuse life-sustaining medical treatments. However, these patients should not be presumed to lack decision-making capacity. Instead, an analysis of the patient's decision-making capacity should be made. Patients who have some degree of decision-making capacity may be able to make a choice about life-sustaining medical treatment and may, in many cases, choose to forgo treatment.     

视空间定位的短时记忆的超广度研究

采用视空间定位的短时记忆任务研究记忆负载的增加对空间位置信息和时间顺序信息的记忆成绩的影响。结果表明,在记忆负载较低时,位置记忆和顺序记忆的成绩相同;当记忆负载逐渐增大时,位置记忆的成绩逐渐上升,而顺序记忆的成绩先上升后下降,两者出现显著性的差异。在这个过程中,短时记忆的加工发生相应的变化,体现了短时记忆加工资源的有限性。     

An Integrative Brief Treatment Approach for Obsessive-Compulsive Disorder

This article reports on the integrated application of cognitive therapy, transactional analysis techniques, and the behavioral technique of response prevention using self-instructional training and behavioral substitution in a brief therapy approach. These methods were applied in the case of a young man who presented with compulsions to perform repetitive and ordering rituals with the belief that it would prevent his girlfriend from becoming pregnant. A 21-year-old white male who had performed 3 to 5 hours of rituals daily for several years was able to eliminate the majority of his compulsive behaviors and reduce his level of anxiety after eight clinical therapy sessions. Results were maintained at 6-month follow-up. The clear precipitating factors and the unusual maintaining variables for the disorder in the client are described. The author discusses the case in light of current theoretical, therapeutic, and biomedical understandings of the disorder.     

Parental Monitoring and the Prevention of Child and Adolescent Problem Behavior: A Conceptual and Empirical Formulation

The present report accomplishes three goals. First, to provide an empirical rationale for placing parental monitoring of children's adaptations as a key construct in development and prevention research. Second, to stimulate more research on parental monitoring and provide an integrative framework for various research traditions as well as developmental periods of interest. Third, to discuss current methodological issues that are developmentally and culturally sensitive and based on sound measurement. Possible intervention and prevention strategies that specifically target parental monitoring are discussed.