Effects of sentential stress and word class upon comprehension in Broca's aphasics

The roles which word class (open/closed) and sentential stress play in the sentence comprehension processes of both agrammatic (Broca's) aphasics and normal listeners were examined with a word monitoring task. Overall, normal listeners responded more quickly to stressed than to unstressed items, but showed no effect of word class. Aphasics also responded more quickly to stressed than to unstressed materials, but, unlike the normals, responded faster to open than to closed class words regardless of their stress. The results are interpreted as support for the theory that Broca's aphasics lack the functional underlying open/closed class word distinction used in word recognition by normal listeners.     

Right-hemisphere language: Familial and nonfamilial sinistrals,cognitive deficits and writing hand position in sinistrals,and concrete-abstract,imageable-nonimageable dimensions in word recognition. A review of interrelated issues

While left-hemisphere language dominance is more general than dextrality, and reversed dominance is less frequent than sinistrality, there are disputes in both the clinical and the experimental literature on a number of related issues which pertain to a possible language contribution from the minor hemisphere. These issues include the nature and extent of bilaterality in sinistrals, whether this is more pronounced in the strongly or weakly sinistral, and in those with or without other sinistral close relatives, whether sinistrality is largely or at all a consequence of birth stress, whether sinistrals differ from dextrals in visuospatial or even verbal skills, Levy's (1978) hypothesis that a knowledge of the hand position employed in writing (hooked or noninverted) may accurately predict language lateralization in sinistrals, and the possible extent of a minor hemisphere contribution to the recognition of high frequency, concrete, or imageable nouns. Findings relating to the above issues are reviewed, and it is concluded that much of the current confusion stems from poor control of subject factors such as sex, strength and family history of handedness, and nature of stimuli and their mode of presentation.     

Cognitive task effects on hemispheric blood flow in humans: Evidence for individual differences in hemispheric activation

Evidence from two indirect measures of hemispheric activity, EEG α and conjugate lateral eye movements, has pointed to the existence of individual differences in hemispheric activation. Results from a more direct indicator of hemispheric activity, regional cerebral blood flow as measured by the ¹³³Xe inhalation method, show that such individual differences can be detected in the distribution of blood in the two hemispheres and that the amount of increase in blood flow in the right relative to the left hemisphere is correlated with performance on a spatial task. These results corroborate and extend the findings from the EEG and eye movement studies and suggest that the dimension of individual differences in hemispheric activation may exert significant influence on cognitive performance and on problem-solving strategies.     

Unilateral agraphia after section of the posterior half of the truncus of the corpus callosum

Children ranging in age from 3 to 12 tapped on a morse key with their index finger as fast as possible. After a control test, they concurrently tapped and recited a nursery rhyme, recited animal names, and memorized shapes. Previous results suggested that more interference in a motor task results from attempting at the same time to perform another task controlled by the same, than by a different, hemisphere. Right-handed tapping and talking both used left hemisphere space; left-handed tapping and talking were controlled by different hemispheres. Relative to silent tapping concurrent talking caused a greater drop in right-hand tapping rate than in left-hand tapping rate in both the rhyme and animal conditions. Interference by shape memorizing was equal across hands. The differential effect of speaking on right-hand preference indicates the left lateralization of speech output control. The size of this effect did not vary with increasing grade level. The findings support the view that speech output control is fully lateralized at least by age 3 years.     

Selective deficit of conceptual structures in aphasia: Class versus thematic relations

Conceptual structures in aphasia were investigated by means of a nonverbal test. The understanding of class and thematic relationships was demonstrated to be selectively impaired according to varieties of aphasic deficit. Broca's aphasics showed difficulty evaluating a thematic relationship and did not differ from normal controls as far as class relationships were concerned. The opposite happened for Wernicke's aphasics whose defect seems to be selectively restricted to class relationships.     

Verbal and nonverbal recognition memory in aphasic and nonaphasic stroke patients

The ability to retain lists of verbal and nonverbalizable items across recurrent recognition tasks was tested in three groups: (1) stroke patients with a left-brain lesion and aphasia, (2) stroke patients with a right-brain lesion and left hemiplegia, and (3) nonneurologically impaired outpatients. As determined with signal detection measures, aphasics were deficient in discriminating words that were to be remembered from those that were not; their recognition of nonverbal visual (geometric art) or auditory (bird calls) patterns, however, was unimpaired. Left hemiplegics showed the opposite pattern. After a long-term interval (<10 min), correct recognition of words was diminished in all groups whereas recognition of visual patterns increased. Both groups of stroke patients adopted material-specific decision criteria which in part accounted for the dissociation of verbal and nonverbal recognition memory by laterality of lesion. Item analysis indicated that aphasics' verbal memory difficulties were affected by acoustic-semantic confusion of list words.     

Cortical stimulation and speech timing: A preliminary observation

Audio recordings of the speech of seven patients receiving cortical stimulation during epilepsy surgery were acoustically analyzed, and duration measurements of the sound /s/ under stimulation and nonstimulation conditions were compared. It was found that in the dominant hemisphere, stimulation tended to significantly increase the duration of /s/; but not all stimulation sites were comparably affected. Stimulation of frontal lobe locations was also observed to more frequently result in durational increases than when temporal or parietal sites were stimulated. However, for sites affected, the actual magnitude of durational increase was comparable among the three lobes.     

Word-finding as a function of stimulus context: Children compared with aphasic adults

A study of object naming in 202 children, aged 5–11 years, demonstrated that varying the stimulus context affected the level of response accuracy. From age 6 to 10, completing a sentence with a noun (auditory) yielded the lowest error scores, naming objects upon hearing a definition (also auditory) produced most errors, while responding with names to pictured objects was of intermediate difficulty. This is the same order of object naming difficulty found in adult aphasic patients. Children older than 10 do not appear to be affected by stimulus context in their object naming. Results are discussed in terms of the relative syntactic difficulty of the two auditory conditions, the unexpected sex differences, and the “aphaseoid” naming errors of children.     

Right-hemisphere speech representation and comprehension of syntax after left cerebral injury

Comprehension of language and visuo-spatial abilities were studied in 12 surgical patients with left cerebral lesions and right-hemisphere speech representation verified by sodium amobarbital tests. When left-hemisphere symptoms preceded the acquisition of speech, impaired understanding of syntactically complex sentences was associated with an early, but not late, onset of convulsive seizures. Other behavioral measures did not show a similar effect of age at seizure onset. Sparing or loss of comprehension could not be related to any aspects of the neurological histories in cases with right-hemisphere speech acquired before the onset of left-hemisphere symptoms. Factors which may have influenced the development of right-hemisphere language comprehension are discussed.