Extinction of drug cue reactivity in methamphetamine-dependent individuals

Conditioned responses to drug-related environmental cues (such as craving) play a critical role in relapse to drug use. Animal models demonstrate that repeated exposure to drug-associated cues in the absence of drug administration leads to the extinction of conditioned responses, but the few existing clinical trials focused on extinction of conditioned responses to drug-related cues in drug-dependent individuals show equivocal results. The current study examined drug-related cue reactivity and response extinction in a laboratory setting in methamphetamine-dependent individuals. Methamphetamine cue-elicited craving was extinguished during two sessions of repeated (3) within-session exposures to multi-modal (picture, video, and in-vivo) cues, with no evidence of spontaneous recovery between sessions. A trend was noted for a greater attenuation of response in participants with longer (4-7 day) inter-session intervals. These results indicate that extinction of drug cue conditioned responding occurs in methamphetamine-dependent individuals, offering promise for the development of extinction- based treatment strategies.     

Money for microbes—Pathogen avoidance and out‐group helping behaviour

Humans have evolved various adaptations against pathogens, including the physiological immune system. However, not all of these adaptations are physiological: the cognitive mechanisms whereby we avoid potential sources of pathogens—for example, disgust elicited by uncleanliness—can be considered as parts of a behavioural immune system (BIS). The mechanisms of BIS extend also to inter‐group relations: Pathogen cues have been shown to increase xenophobia/ethnocentrism, as people prefer to keep their societal in‐group norms unaltered and “clean.” Nonetheless, little is known how pathogen cues influence people's willingness to provide humanitarian aid to out‐group members. We examined how pathogen cues affected decisions of providing humanitarian aid in either instrumental (sending money) or non‐instrumental form (sending personnel to help, or accepting refugees), and whether these effects were moderated by individual differences in BIS sensitivity. Data were collected in two online studies (Ns: 188 and 210). When the hypothetical humanitarian crisis involved a clear risk of infection, participants with high BIS sensitivity preferred to send money rather than personnel or to accept refugees. The results suggest that pathogen cues influence BIS‐sensitive individuals' willingness to provide humanitarian aid when there is a risk of contamination to in‐group members.     

Substance use and mothers’ neural responses to infant cues

Substance use may influence mothers’ responsiveness to their infants and negatively impact the parent–infant relationship. Maternal substance use may co-opt neural circuitry involved in caregiving, thus reducing the salience of infant cues and diminishing the sense of reward experienced by caring for infants. Gaps in understanding exist with regard to the mechanisms by which substance use operates to influence mothers’ processing of infant cues and how this translates to caregiving. Therefore, we examined how substance use might relate to maternal neural responses to infant cues using event-related potentials (ERPs). Substance-using (n = 29) and nonsubstance-using (n = 29) mothers viewed photographs of infant faces and heard recordings of infant vocalizations while electroencephalography was recorded simultaneously. Three specific ERP components were used to examine initial processing of infant faces (N170) and cries (N100), and attentional allocation to infant faces and cries (P300). Substance-using mothers did not discriminate facial affect at early encoding stages (N170), were generally slower to orient to infant cries (N100), showed heightened responses to neutral faces (P300), and failed to adaptively differentiate between high-distress versus low-distress cries (P300). These differences may be important to caregiving behaviors associated with the formation of mother–child attachment. Implications are discussed, as are limitations and future directions.     

Dynamic self- and other-focused emotional intelligence: A theoretical framework and research agenda

This paper introduces a theoretical framework for research on the dynamics of self- and other-focused emotional intelligence (EI). The EI-framework focuses specifically on the interplay between different EI dimensions when individuals are processing their own emotions and the emotions of others. The framework captures different phases of processing self- and other-emotions. The first phase consists of situational cues (e.g., an argument) that elicit interdependent emotions in the self and others. The next phase specifies differential and interacting effects of EI dimensions when processing these emotions, and the third phase describes what proximal and distal consequences this processing may have. In addition, the framework includes candidate dispositional and contextual factors (e.g., emotion type, motivation) that may qualify the process.     

Seeing how it’s done: matching conditions for observer rats (Rattus norvegicus) in the bidirectional control

In an attempt to increase the reliability of the demonstrator-consistent responding effect produced in the bidirectional control procedure, experiments 1–4 sought conditions that would magnify the matching effect. The aim was to produce a robust demonstrator-consistent responding effect in order that future analytic experiments could investigate the psychological processes responsible for this effect. The joystick responses of observer rats trained using the standard bidirectional control procedure parameters were compared with those of observers subject to conditions identified in the social learning literature as favourable for imitation. Unlike mice, observer rats in experiments 1 a and 1 b tended to push a joystick in the same direction as their demonstrators when the demonstrators were either familiar or unfamiliar males and females. Comparable demonstrator-consistent responding occurred following observation of a standard and a salient joystick response (experiment 2). Experiment 3 showed that the discriminative accuracy of a demonstrator’s responding was important for matching behaviour, and suggested that matching might be enhanced with more than the conventional single observation session. Experiment 4 confirmed that the bidirectional control effect is sensitive to the amount of observational experience; after six observation sessions, demonstrator-inconsistent responding occurs. The results of experiments 1–3 are, and those of experiment 4 are not, compatible with the hypothesis that demonstrator-consistent responding in the bidirectional control is caused by olfactory cues deposited by demonstrators on the joystick. Received: 29 May 2000 / Accepted after revision: 28 August 2000     

Social stories, written text cues, and video feedback: effects on social communication of children with autism.

This study investigated the effects of written text and pictorial cuing with supplemental video feedback on the social communication of 5 students with autism and social deficits. Two peers without disabilities participated as social partners with each child with autism to form five triads. Treatment was implemented twice per week and consisted of 10 min of systematic instruction using visual stimuli, 10 min of social interaction, and 10 min of self‐evaluation using video feedback. Results showed increases in targeted social communication skills when the treatment was implemented. Some generalized treatment effects were observed across untrained social behaviors, and 1 participant generalized improvements within the classroom. In addition, naive judges reported perceived improvements in the quality of reciprocal interactions. These findings support recommendations for using visually cued instruction to guide the social language development of young children with autism as they interact with peers without disabilities.     

仿真场景下类别空间关系判断中的注意分配

研究采用“提示-目标”的范式,并结合单、双任务的方法探讨仿真场景下类别空间关系判断中的空间注意分配。结果发现：提示影响类别空间关系判断效率,不同类型提示对类别空间关系判断的影响不同;类别空间关系判断还受到任务类型和判断类型的影响。由此得出以下结论：提示有助于注意资源的集中,提示越有效注意资源分配效率越高;注意分配受到第二任务要求的影响;决定注意分配策略的认知判断过程可能是持续存在的     

An assessment of the role of handling cues in "spontaneous recovery" after extinction

Three experiments examined the assertion that presession handling cues that accompany training with reinforcement might account for spontaneous recovery when they reoccur following extinction. In Experiment 1, after extensive training on a variable-interval schedule, key pecking in pigeons was extinguished following either normal or distinctively different handling and transportational cues. Those cues resulted in enhanced spontaneous recovery 24 hr later when normal cues were reinstated. In Experiment 2, however, subjects tested following the normal handling cues showed no more spontaneous recovery than did subjects that spent the entire extinction-test interval in the experimental chambers and thus were tested without handling cues altogether. In Experiment 3, a group whose test for recovery began 10 min after being placed in the chambers yielded as much spontaneous recovery as did a group tested normally. Furthermore, a group for which extinction began at mid-session and for which handling therefore could not be a discriminative cue for extinction showed no more spontaneous recovery than did the other two groups. Handling cues thus contributed to spontaneous recovery only after explicit discrimination training, as provided in Experiment 1.