特应性皮炎与过敏进程

过敏性疾病已成为备受关注的社会问题,包括特应性皮炎、食物过敏、过敏性鼻炎、过敏性哮喘等,其发生和发展一直是学术界和社会公众高度关注的话题。变态反应症状可表现在皮肤、胃肠道、鼻腔、支气管等不同部位,流行病学研究发现各类过敏性疾病的出现呈现从儿童湿疹、食物过敏逐渐向过敏性鼻炎、过敏性哮喘发展的过程,婴儿或儿童早期出现的伴高IgE的特应性皮炎往往预示着未来会发生其他过敏性疾病,这种现象被称为变态反应性疾病的自然进程又称过敏进程,即“AllergyMarch”。本文就特应性皮炎与过敏进程的相关研究进行回顾与讨论,以期引起社会各界对特应性皮炎的重视。     

Temperamental Differences Between Healthy,Asthmatic, and Allergic Children Before Onset of Illness: A Longitudinal Prospective Study of Asthma Development

The authors investigated the link between children's temperament and the development of asthma and allergies. Prospective longitudinal data on children at the ages of 3-5 months, 3-5 years, and 7-9 years were collected. At age 7-9 years, analyses were performed on data for 3 groups of children (n = 42): those with asthma (no allergies), those with allergies (no asthma), and those with neither asthma nor allergies (the control group). Data for children who developed asthma or allergies prior to age 7-9 years were not analyzed. Differences were found in the premorbid period between the control group and the children who later developed asthma or allergies as well as between the asthma and allergy groups. After onset of illness, no temperamental differences were observed between the 3 groups. The study shows the importance of longitudinal design for asthma research.     

Parent Report of Attention Problems Predicts Later Adaptive Functioning in Children with Brain Tumors

Children with brain tumors are at risk for psychological and behavioral difficulties. This study examined the ability of parent report of attention problems, withdrawal, anxiety, and depression, as well as IQ, to predict later adaptive functioning in 42 children treated for brain tumors. Age at diagnosis, SES, gender, and scores on the Neurological Predictor Scale (NPS) also were examined as predictors. Parent report of attention problems, SES, and NPS were significant predictors of later adaptive functioning across domains. This finding highlights the ability of parent report of attention problems to predict later adaptive functioning in children treated for brain tumors.     

哮喘控制与医疗改革

达到并维持哮喘控制和减少未来风险是哮喘的管理目标,绝大多数患者通过药物治疗可以实现这一目标。但目前哮喘控制率很低,除与GINA和我国哮喘诊治规范实施不足有关外,还与传统医疗结构、医疗体制和医疗观念有关,加速医疗改革,人人享有基本医疗卫生服务是提高哮喘控制率的重要环节。     

儿童支气管哮喘诊断的几点思考

支气管哮喘（以下简称哮喘）是小儿常见的慢性气道疾病。5岁及以下儿童哮喘的诊断极为困难,是富有挑战性的;因为诊断只能依靠临床判断、症状评价和体征分析。病毒感染所至的喘息在婴幼儿期很常见,与哮喘鉴别较困难。目前还没有诊断婴幼儿期哮喘的特异检测手段和方法,因此诊断需要综合考虑,包括反复喘息的类型、特异体质病史、哮喘危险因素、长期随访、广泛鉴别诊断和观察对支气管舒张剂及抗炎治疗的反应。     

支气管哮喘伴发抑郁与人格、应对和社会支持的关系分析

研究分析支气管哮喘伴发抑郁与人格、应对和社会支持的关系。对216例支气管哮喘患者应用自评抑郁量表、大五人格量表、特质应对方式问卷和社会支持评定量表进行调查,对收集到的数据进行Pearson相关分析、多元逐步回归分析和路径分析。结果显示49．1％的支气管哮喘患者存在不同程度的抑郁情绪;哮喘患者的抑郁程度、人格、应对方式和社会支持之间存在着不同程度的显著相关;人格、应对和社会支持都是影响支气管哮喘伴发抑郁的影响因素,人格的神经质是其重要的预测因素,它除了能直接影响哮喘患者的抑郁程度,还能通过社会支持和应对方式对其起间接的作用。研究提示人格的神经质、公正严谨性和消极应对方式是支气管哮喘伴发抑郁的直接的预测因素。     

Developmental, Gender, and Health-Related Variations in Self-Competence and Depressed Mood Among School-Aged Urban Children with Asthma: A Pilot Study

This pilot study examined associations among asthma status, gender, self-competence, and depressed mood across 2 years of middle childhood in a sample of 57 urban children. Results revealed no differences across health status in self-competence and depressed mood. Girls showed a significant increase in levels of self-competence from Year -1 to 2. Higher levels of self-competence were associated with lower levels of depressed mood at Year 1, at Year 2, and from Year 1 to 2. Self-competence accounted for a larger amount of the variance in depressed mood for girls than for boys. Changes in levels of self-competence were significantly associated with changes in depressed mood for girls only. Results suggest meaningful gender-based differences in the socioemotional trajectories of school-aged children, which should be considered when designing preventative interventions in urban environments.     

Depression,Panic-Fear,and Quality of Life in Near-Fatal Asthma Patients

The aim of this study was to assess the relationships between depressive symptoms and symptom-centered panic-fear (P-F), and reports of health-related quality of life (HRQOL), in persons with near-fatal asthma (NFA), controlling for age, gender, and pulmonary function. Forty persons with NFA were interviewed. Sociodemographic and clinical asthma-related information were collected. HRQOL was assessed by the SF-36 Health Questionnaire, depressive symptoms were assessed by the Beck Depression Inventory, and P-F was assessed by the P-F scale of the Asthma Symptom Checklist. Multiple regression analyses were carried out with the Physical Component Summary (PCS) and the Mental Component Summary (MCS) of the SF-36 as a dependent variable, and depressive symptoms, P-F, age, gender, and pulmonary function as independent variables. Results showed that P-F and age were associated with PCS, whereas depressive symptoms accounted for a marked percentage of the variance explained in MCS. Neither gender nor pulmonary function were related to HRQOL. In conclusion, depressive symptoms and P-F play an important role in how persons with NFA assess their HRQOL. These patient-centered variables are potentially modifiable and may offer new ways to intervene in order to improve HRQOL in persons with NFA.     

支气管哮喘治疗重点的转移与“祛痰化瘀”的治则渊源

随着对支气管哮喘(哮喘)发病机制深入的研究,医学界将哮喘治疗的目标被定位于气道炎症的消除,但其治疗仍局限在气道局部炎症的控制,而对全身免疫功能紊乱束手无策。祖国医学讲究整体观念和治病求本,将气道炎症及与此相关的炎症介质和因子统归于痰瘀。气道炎症与痰瘀阻肺为不同医学体系对同一病症的诠释,二者殊途同归。祖国医学注重辩证施治、合理运用理法方药,疗效确实,副作用小,可以弥补糖皮质激素等药物的不足。     

Asthma-Specific Quality of Life in Older Adolescents and Young Adults with Long-Standing Asthma: The Role of Anxiety and Depression

The present study examined the influence of psychological comorbidity (i.e., anxiety and depression) on asthma-specific quality of life (QOL). Sixty-four older adolescents and young adults with childhood onset asthma completed measures of anxiety, depression, and asthma-specific QOL. Objective assessments of illness severity were obtained via a semistructured interview and pulmonary function test. Results revealed that the combination of anxiety and depression severity contributed significant variance to asthma QOL after statistically controlling demographic and disease covariates. Moreover, anxiety demonstrated a significant main effect on asthma QOL. Findings suggest that assessment of anxiety may help identify individuals who are at risk for poorer asthma-specific quality of life. Such early interventions can be effectively incorporated into comprehensive biopsychosocial treatment and behavioral self-management programs for individuals with asthma.