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181.
Lateral asymmetry in phonological processing: relating behavioral measures to neuroimaged structures
Coney J 《Brain and language》2002,80(3):355-365
Recent neuroimaging studies have revealed neuroanatomical centers of activation that appear to be linked specifically to phonological processes. Furthermore, there is evidence that these centers of activation are more likely to be bilaterally represented in women than in men. However, behavioral evidence of such hemispheric asymmetries or of related sex differences is somewhat inconsistent. Two experiments were carried out to determine whether behavioral correlates of the neuroimaging findings could be demonstrated. The first experiment employed a rhyme-matching task used in a recent neuroimaging study, in which two nonsense words were projected successively to the left or right sides of the visual field. The results indicated that the left hemisphere was superior for this task. An analysis of gender effects, however, revealed that the asymmetry was restricted to men. The second experiment employed a lateralized pseudohomophone detection task that was designed to determine whether the results of the first experiment could be confirmed in the context of a phonological task with a simpler structure. This experiment broadly supported the findings of the first experiment. The results support the specialization of the left hemisphere for phonological processing, and the existence of gender differences with respect to these processes. 相似文献
182.
Effect of speech task on intelligibility in dysarthria: a case study of Parkinson's disease 总被引:2,自引:0,他引:2
This study assessed intelligibility in a dysarthric patient with Parkinson's disease (PD) across five speech production tasks: spontaneous speech, repetition, reading, repeated singing, and spontaneous singing, using the same phrases for all but spontaneous singing. The results show that this speaker was significantly less intelligible when speaking spontaneously than in the other tasks. Acoustic analysis suggested that relative intensity and word duration were not independently linked to intelligibility, but dysfluencies (from perceptual analysis) and articulatory/resonance patterns (from acoustic records) were related to intelligibility in predictable ways. These data indicate that speech production task may be an important variable to consider during the evaluation of dysarthria. As speech production efficiency was found to vary with task in a patient with Parkinson's disease, these results can be related to recent models of basal ganglia function in motor performance. 相似文献
183.
Griffin ZM 《Brain and language》2002,80(3):465-487
Three experiments examined the contribution of phonological availability in selecting words as predicted by interactive activation models of word production. Homophonous words such as week and weak permitted a word's phonological form to be activated on priming trials without selection of its meaning or lemma. Recent production of a homophone failed to significantly increase production of its twin as a sentence completion. However, speakers were significantly more likely to complete a sentence with a recently read or generated unambiguous word. This increase in response probability was unaffected by word frequency. The results constrain the degree to which experience and phonological availability may affect word selection in spoken language production. 相似文献
184.
A Hebrew adaptation of Gardner and Brownell's (1986) "Right Hemisphere Communication Battery" (HRHCB) was administered to 27 right brain-damaged (RBD) patients, 31 left brain-damaged (LBD) patients, and 21 age-matched normal controls. Both patient groups showed deficits relative to controls and overall there was no difference between the two patient groups. A factor analysis of patients' scores on the HRHCB yielded two interpretable factors, a verbal and a nonverbal one. These factors were not lateralized. Performance of patients on the HRHCB correlated significantly and positively with performance on most tests of basic language functions, measured with a Hebrew adaptation of the "Western Aphasia Battery" (HWAB) and with other cognitive functions measured with standardized neuropsychological tests. There were stronger correlations of HRHCB with subtests of the HWAB in LBD patients and with nonlanguage cognitive tests in RBD patients. In the LBD group, HRHCB subtests' scores correlated negatively with lesion extent in frontal and temporal perisylvian regions. Such localization was not observed in RBD patients. The results argue against selective right hemisphere (RH) involvement in the RHCB, alleged to measure pragmatic aspects of language use, and show, instead, bilateral involvement. The results also argue against a modular organization of these functions of language use, especially in the RH. 相似文献
185.
Ziegler W 《Brain and language》2002,80(3):556-575
This study was focused on the potential influence of task-related factors on oral motor performance in patients with speech disorders. Sentence production was compared with a nonspeech oral motor task, i.e., oral diadochokinesis. Perceptual and acoustic measures of speech impairment were used as dependent variables. Between-task comparisons were made for subsamples of a population of 140 patients with different motor speech syndromes, including apraxia of speech and cerebellar dysarthria. In a further analysis subgroups were matched for speaking rate. Overall, dysdiadochokinesis was correlated with the degree of speech impairment, but there was a strong interaction between task type and motor speech syndrome. In particular, cerebellar pathology affected DDK to a relatively greater extent than sentence production, while apraxic pathology spared the ability of repeating syllables at maximum speed. 相似文献
186.
Neuronal changes in normal human aging and Alzheimer's disease 总被引:8,自引:0,他引:8
This article discusses age-related changes in brain weight, total number of cortical neurons, cortical dendrites, spine, and synapse density. The conclusion is that the present outlook is less grim than it was 30 years ago. Age-related reduction appears to be specific to brain region and cortical layer rather than a general feature. In addition, we describe a different pattern of changes that occur in Alzheimer's disease patients. This review concludes that the association cortices in particular are affected in aging and Alzheimer's disease and that the primary visual and somatosensory cortices are relatively spared. 相似文献
187.
We examine the hypothesis that the efficiency of executive control processes is less stable over time in older than younger adults. An age-related decrease in the efficiency of executive control should result in an increase in performance variability in task conditions requiring the recruitment of executive control processes and not in task conditions requiring minimal involvement of executive control. Performance variability was similar for younger and older adults in task conditions requiring minimal executive control and greater for older than younger adults in task conditions requiring executive control. These and other data are consistent with the proposal that aging is associated with a decrease in the stability of executive control over time. 相似文献
188.
Sentence processing deficits in two Cantonese aphasic patients 总被引:1,自引:0,他引:1
This paper reports the performances of two Cantonese aphasics on tasks examining their sentence processing deficits. The data on sentence comprehension show that thematically noncanonical sentences, full passives, and subject-gap sentences present greater difficulty to these patients than canonical sentences, truncated passives, and object-gap sentences, respectively. These patterns are consistent with previous observations on Chinese aphasics and are expected given the structural differences between Chinese and English. In a Cantonese grammaticality judgment test, a set of structures are identified that can elicit clear judgments from normal subjects and aphasics, contrary to the claim that grammaticality judgments in Chinese are probabilistic and fragile. Most interestingly, the patients' overall performance patterns reveal a double dissociation between sentence comprehension and judgment of sentence well-formedness, suggesting that the two tasks are supported by independent processing mechanisms. 相似文献
189.
Quantitative analysis of aphasic sentence production: further development and new data 总被引:1,自引:0,他引:1
The narrative production of patients with Broca's aphasia and age-and education-matched control subjects was analyzed using the Quantitative Production Analysis (Saffran et al., 1989), a procedure designed to provide measures of morphological and structural characteristics of aphasic production. In addition to providing data for a larger number of subjects than in the original study, we provide data on interrater and test-retest reliability. The data were also submitted to factor and cluster analyses. Two factors characterized the data and the cluster analysis yielded four sets of patients who performed differently on these factors. In particular, there is evidence that agrammatic patients can differ in their production of free and bound grammatical morphemes, substantiating earlier claims in the literature. 相似文献
190.
We have recently reported a correlation between schizophrenialike symptoms and the degree of pseudoneglect in healthy right-handers. We aimed to investigate the effect of familial sinistrality (FS) on this relation. Seventy-six healthy right-handers were divided into four groups on the basis of gender and FS. A computerized version of Corsi's task was used as the visuospatial task. Subjects filled in the Magical Ideation Scale (MI), which asked for delusionlike beliefs, and performed the Corsi's task using each hand. Performance of both hemispaces was separately evaluated. In all groups, performance of the left hemispace was better than that of the right hemispace and FS+ subjects performed better than FS- subjects. When the right hand was used, performance was correlated to MI scores only for FS- groups. Findings suggest that the correlation between right-sided neglect and proneness to schizotypy in normal right-handers is affected by FS. 相似文献