Contrasting Social Climates of Small Peer-Run Versus a Larger Staff-Run Substance Abuse Recovery Setting

This study compared the social climate of peer‐run homes for recovering substance abusers called Oxford House (OH) to that of a staffed residential therapeutic community (TC). Residents of OHs (N = 70) and the TC (N = 62) completed the Community Oriented Programs Environment Scales. OHs structurally differ on two primary dimensions from TCs in that they tend to be smaller and are self‐run rather than professionally run. Findings indicated significantly higher Involvement, Support, Practical Orientation, Spontaneity, Autonomy, Order and Organization, and Program Clarity scores among the OH compared to TC residents. Additional analyses found the OH condition was higher Support, Personal Problem Orientation, and Order and Organization scores among women compared to men residents. These results suggested that these smaller OH self‐run environments created a more involving and supportive social milieu than a larger staff‐run TC. These findings are interpreted within Moos' ( 2007 ) four theoretical ingredients (i.e., social control, social learning, behavioral economics, and stress and coping), which help account for effective substance abuse treatment environments.     

Mechanism of isoflavone aglycone's effect on cognitive performance of senescence-accelerated mice

This study investigated the effect of isoflavone aglycone (IA) on the learning and memory performance of senescence-accelerated mice, and explored its neural protective mechanism. Results showed that SAM-P/8 senescence-accelerated mice treated with IA performed significantly better in the Y-maze cognitive test than the no treatment control (P<0.05). The cortex AchE activity, serum SOD and GSH-Px activities were notably higher (P<0.05). MDA concentration and the β-secretase activity in the hippocampal tissue were both lower (P<0.05). Additionally, the number of hippocampal neurons was increased and cell morphology was significantly improved. Data suggested that IA could indirectly increase concentration of the cholinergic neural transmitter Ach through regulation of AchE, therefore improving the central cholinergic function and enhancing the learning and memory ability. By reducing the β-secretase activity, IA could decrease the formation and deposition of insoluble Adebris, relieve the resulted toxicity and damage to neurons, and thereby effectively protect the nervous system.     

Fundamental Beliefs,Origin Explanations and Perceived Effectiveness of Protection Measures: Exploring Laypersons' Chains of Reasoning About Influenza

Laypersons' chains of reasoning in explaining recent influenza outbreaks are investigated. Drawing on social representations theory, fundamental worldviews, that is, the belief in a dangerous world (BDW), are postulated to anchor explanations of disease origins, which in turn affect perceived effectiveness of protection measures. Our study, based on a longitudinal survey among the general public in Switzerland, showed that the lower people's BDW scores, the more they appeal to natural origins to explain outbreaks and the more they perceive official protection measures as effective. The higher people's BDW scores, the more they explain outbreaks via hygienic origins, which are linked with out‐group discrimination measures, and conspiracy origins, which are linked with lower perceived effectiveness of aid intervention measures. Copyright © 2013 John Wiley & Sons, Ltd.     

Profession Differences in Family Focused Practice in the Adult Mental Health System

There is a large gulf between what psychiatric services should (or could) provide and what they do in practice. This article sought to determine practice differences between the differing professions working in adult mental health services in terms of their family focused work. Three hundred and seven adult mental health professionals completed a cross‐sectional survey of family focused practices in adult mental health services. Findings highlight that social workers engaged in more family focused practice compared to psychiatric nurses, who performed consistently the lowest on direct family care, compared to both social workers and psychologists. Clear skill, knowledge, and confidence differences are indicated between the professions. The article concludes by offering direction for future profession education and training in family focused practices.     

Are Multicultural Courses Addressing Disparities? Exploring Multicultural and Affirmative Lesbian,Gay, and Bisexual Competencies of Counseling and Psychology Students

Clinical training and counselor competency are essential for ethical practice when working with multiethnic, lesbian, gay, bisexual (LGB), and transgender clients. In this study, the author examined how multicultural courses related to students' (N = 286) LGB and multicultural competencies. Self‐reported multicultural and LGB competencies varied significantly depending on the number and types of diversity education reported. Multicultural courses significantly predicted students' multicultural, but not LGB counselor competency. Political conservatism was the strongest predictor for both multicultural and sexual orientation competencies. La formación y competencias multiculturales afirmativas hacia individuos gays, lesbianas y bisexuales (LGB, por sus siglas en inglés) de consejeros son esenciales para una práctica clínica ética. En este estudio, el autor examinó cómo los cursos multiculturales se relacionaron con las competencias multiculturales de un grupo de estudiantes (N = 286). Las competencias multiculturales y sobre LGB autorreportadas variaron significativamente dependiendo del número y tipos de educación sobre diversidad reportados. Los cursos multiculturales predijeron de forma significativa la competencia multicultural de los estudiantes, pero no la competencia sobre LGB en consejería. La ideología política conservadora fue el predictor más fuerte de las competencias multiculturales y sobre orientación sexual.     

CXCR4和CXCR7在甲状腺癌中的表达及病理意义

研究甲状腺癌组织中趋化因子4受体（CXCR4）和趋化因子7受体（CXCR7）的表达情况及临床病理意义。应用免疫组织化学PV-6000法及Westernblot法检测CXCR4与CXCR7在甲状腺癌中的表达。二者在甲状腺癌与甲状腺良性疾病组织的差异均具有统计学意义（P〈0．05）,在甲状腺癌中表达仅与淋巴结转移有关（P〈0．05）,CXCR4与CXCR7之间呈正相关。Westernblot结果提示二者在甲状腺癌中的表达率高于癌旁及甲状腺腺瘤。CXCR4和CXCR7的表达水平与淋巴结转移相关,可作为甲状腺癌预后的判断指标。     

LKB1蛋白在食管鳞癌组织中的表达及意义

为了探讨肝激酶B1（LKB1）蛋白在食管鳞癌组织中的表达水平及其与食管鳞癌临床特征及生存期的关系,应用免疫组化方法检测120例食管鳞癌患者组织中LKB1蛋白表达情况并对诸多临床特征进行相关性分析研究,发现LKB1蛋白在食管癌旁正常组织的阳性表达率高于癌组织;LKB1蛋白表达与患者年龄、性别、肿瘤部位、病变长度及浸润深度无关而与分化程度、淋巴结转移及临床分期（TNM）相关,且LKB1蛋白阴性组预后较阳性组差.可见LKB1视为抑癌基因影响食管鳞癌的预后,可能成为食管鳞癌新型的临床预后指标之一.     

On the Decision to Explore New Alternatives: The Coexistence of Under‐ and Over‐exploration

The decision whether to explore new alternatives or to choose from familiar ones is implicit in many of our daily activities. How is this decision made? When will deviation from optimal exploration be observed? The current paper examines exploration decisions in the context of a multi‐alternative “decisions from experience” task. In each trial, participants could choose a familiar option (the status quo) or a new alternative (risky exploration). The observed exploration rates were more sensitive to the frequent outcome from choosing new alternatives than to the average outcome. That is, the implicit decision whether to explore a new alternative reflects underweighting of rare events: Over‐exploration was documented in “Rare Disasters” environments, and insufficient exploration was evident in “Rare Treasures” environments. In addition, the results reveal a decrease in exploration of new alternatives over time even when it is always optimal and some exploration even when it is never reinforcing. These results can be captured with models that share a distinction between “data collection” and “outcome‐driven” decision modes. Under the data collection mode, the decision maker collects information about the environment, to be used in future choices. Under the outcome‐driven mode, the decision maker relies on small samples of previous experiences with familiar versus unfamiliar alternatives, before the selection of a specific alternative. The predictive value of a two‐parameter “explorative sampler” quantification of these assumptions is demonstrated. Copyright © 2013 John Wiley & Sons, Ltd.