工作记忆中央执行功能的特异性和可分离性

采用3种中央执行功能,对中央执行功能的特异性和可分离性进行研究。选取青年和老年被试各31名。每位被试都要参加3种中央执行功能2个难度水平的任务和瑞文标准推理测验。结果发现：记忆刷新的年龄效应不能完全由液态智力的年龄差异来解释;虽然同种执行功能内不同难度任务的年龄效应类似,但不同执行功能的年龄效应不同,从大到小依次为记忆刷新、随机生成和选择性注意;控制液态智力的影响后,同种执行功能内不同难度任务间的相关仍然显著,而不同中央执行功能之间的相关不显著;另外,本实验条件下选择性注意与液态智力相关不显著,且不存在年老化现象。研究结果表明中央执行功能相对于液态智力具有一定的特异性,并且可以进一步分离为一些相互独立的子功能。     

Effets comportementaux et cognitifs de l'engagement dans un acte préparatoire activant un élément central versus périphérique de la représentation du don d'organes

We render an account of a research programme that links two fields of study usually unconnected: the field of the freely agreed submission and the field of social representations. Two hypothesis are tested in the foot-in-the door paradigm: participants that agree to perform an initial request (to sign a petition) that selects a core element of the representation of organ donation: a) will be more inclined to agree to perform the target request (to sign a donor card); and b) will have an attitude more favourable about organ donation than participants that agree to perform an initial request that selects a peripheral element. The two experiments presented confirm these hypotheses.     

数学学习困难与工作记忆关系研究的现状与前瞻

工作记忆是一种对信息进行暂时加工和贮存的能量有限的记忆系统,在许多复杂的认知活动中起重要作用,工作记忆缺陷是造成数学学习困难的根本原因。数学学习困难儿童都存在视觉空间模板、语音回路以及中央执行器功能等方面的缺陷,工作记忆的各成分对数学困难者的影响不同。今后研究将以整体的、发展的视角,不断改进研究方法,将行为研究和神经加工机制研究相结合。     

MINDING QUANTA AND COSMOLOGY

The revolution in science inaugurated by quantum physics has made us aware of the role of observation in the construction of data. Eugene Wigner remarked that in quantum physics we no longer have observables (invariants), only observations. Tongue in cheek, I asked him whether that meant that quantum physics is really psychology, expecting a gruff reply to my sassiness. Instead, Wigner beamed understanding and replied "Yes, yes, that's exactly correct." David Bohm pointed out that were we to look at the cosmos without the lenses of our telescopes we would see a hologram. I extend Bohm's insight to the lens in the optics of the eye. The receptor processes of the ear and skin work in a similar fashion. Without these lenses and lenslike operations all of our perceptions would be entangled as in a hologram. Furthermore, the retina absorbs quanta of radiation so that quantum physics uses the very perceptions that become formed by it. In turn, higher-order brain systems send signals to the sensory receptors so that what we perceive is often as much a result of earlier rather than just immediate experience. This influence from inside out becomes especially relevant to our interpretation of how we experience the contents and bounds of cosmology that come to us by way of radiation.     

中部崛起背景下的城市社区卫生服务主要影响因素研究

通过武汉市中心城区社区卫生服务的实证调研,多因素分析和建模,寻求影响中部地区城市社区卫生服务的主导因素,在此基础上提出若干可行的政策建议,旨在为管理决策、促进社区卫生服务及构筑新型城市卫生服务体系等提供信息支持服务。     

伤害性躯体感觉的中枢网络动态编码过程

痛觉是感受躯体所受伤害性刺激的保护性感觉;慢性痛则是耗费巨额医疗费用的顽固性疾病。近年来的研究表明,疼痛感知觉的形成是一个大规模的中枢网络编码过程,包括了感觉、情绪、认知等若干不同的维度,牵涉到脊髓、脑干、边缘系统、皮层等多个相关结构。慢性痛则是一种由神经网络编码异常所导致的中枢性疾患。上述编码过程的任何异常都可能导致慢性痛。认识痛觉的中枢网络编码机制,将促进人们对感觉与情绪形成过程的深入理解,并有助于寻求新的临床疼痛治疗措施     

Neurochemical mechanisms underlying amygdaloid modulation of aggressive behavior in the cat

Studies designed to determine the respective roles of substance P, excitatory amino acids, and enkephalins in amygdaloid modulation of defensive rage behavior in the cat are presented. The basic design of these studies involved three stages. In stage I, cannula electrodes for stimulation and drug infusion were implanted into medial hypothalamic or midbrain periaqueductal gray (PAG) sites from which defensive rage behavior could be elicited. Then, a stimulating electrode was implanted into a site within the medial, basal, or central nuclear complex from which modulation of the defensive rage response could be obtained. Amygdaloid modulation of defensive rage was determined in the following manner: it employed the paradigm of dual stimulation in which comparisons were made of response latencies between alternate trials of dual (i. e., amygdala = medial hypothalamus [or PAG]) and single stimulation of the hypothalamus or PAG alone. Thus, stage I established the baseline level ofmodulation (i. e., facilitation or suppression of defensive rage) in the predrug stimulation period. In stage II, a selective or nonselective receptor antagonist for a given transmitter system was administered either peripherally or intracerebrally at the defensive rage site, after which time the same dual stimulation paradigm was then repeated over the ensuing 180 min postinjection period in order to determine the effects of drug delivery upon amygdaloid modulation of defensive rage. Stage III of the study took place at the completion of the pharmacological testing phase. The retrograde axonal tracer, Fluoro-Gold, was microinjected into the defensive rage site within the medial hypothalamus or PAG, and following a 6-14 day survival period, animals were sacrificed and brains were processed for histological and immunocytochemical analyses for the neurotransmitters noted above. This procedure thus permitted identification of cells within the amygdala which were labeled retrogradely and which were also immunostained positively for substance P, excitatory amino acids, or enkephalin. For studies involving substance P, defensive rage was elicited from the medial hypothalamus and for studies examining the roles of excitatory amino acids and enkephalin, defensive rage was elicited from the PAG. In the first study, facilitation of hypothalamically elicited defensive rage was obtained with dual stimulation of the medial nucleus of the amygdala. In separate experiments, the selective NK₁ non-peptide antagonist, CP 96,345, was administered both peripherally as well as intracerebrally into the hypothalamic defensive rage sites in doses of 0.5-4.0 mg/kg (i. p.) and 0.5-2.5 nmol (i. c.). Following drug delivery, the facilitatory effects of medial amygdaloid stimulation were blocked in a dose- and time-dependent manner in which the effects were noted as early as 5 min postinjection. The maximum drug dose (4.0 mg/kg) employed for peripheral administration resulted in a 42% reduction in the facilitatory effects of the medical amygdala (P < 0.002). This drug, when microinjected directly into medial hypothalamic defensive rage sites at the maximum dose level of 2.5 nmol, resulted in an 84% reduction of the suppressive effects of amygdaloid stimulation (P < 0.5) at 5 min postinjection. In the next study, an N-methyl-D-aspartate (NMDA) antagonist, DL-α-amino-7-phosphonoheptanoic acid (AP-7), was administered either peripherally (0.1-1.0 mg/kg) or intracerebrally (0.2 and 2.0 nmol) into PAG defensive rage sites. Facilitation of defensive rage behavior, which was observed following dual stimulation of the basal amygdala and PAG, was significantly reduced by either route of drug administration in a dose- and time-dependent manner. At the maximum dose level of peripheral administration, AP-7 reduced amygdaloid facilitation of defensive rage by 63% (P < 0.001) for 60 min, postinjection. A smaller (i. e., 19%) but still significant (P < 0.05) reduction in facilitation was obtained following intracerebral administration of the drug. In a third study, the non-selective opioid receptor antagonist, naloxone (27.5 nmol), infused directly into PAG defensive rage sites, totally blocked the suppressive effects of central amygdaloid stimulation for a period of 30 min (P < 0.05) in a dose- and time-dependent manner. The anatomical phase of this study revealed the following relationships: 1) that large numbers of neurons projecting to the medial hypothalamus from the medial amygdala immunoreact positively for substance P; 2) that neurons projecting to the PAG from the basal complex of amygdala immunoreact positively for glutamate and aspartate; and 3) that neurons located within the central nucleus of the amygdala which project to the PAG immunoreact positively for met-enkephalin. Collectively, these observations provide new evidence which characterizes the likely neurotransmitters linked with specific amygdaloid pathways subserving the modulation of defensive rage behavior in the cat.     

中央执行负荷对成人估算策略运用的影响

随机选取128名大学生为被试, 运用选择/无选法研究范式, 考察了不同中央执行负荷对估算策略运用的影响。结果发现：(1)中央执行负荷不影响策略分布; (2)策略运用条件、中央执行负荷影响策略执行。主次一致任务, 负荷对策略执行反应时的影响随负荷强度增大而增大, 对策略执行精确度影响不大; 而对主次不一致任务, 低负荷对策略执行反应时及精确度影响都不明显; (3)策略运用条件、中央执行负荷影响策略选择。负荷强度对策略选择反应时起重要作用, 只有当次级任务负荷高时, 干扰作用才明显; (4)成人的策略选择适应性受负荷强度的影响。无负荷条件下个体策略适应性更好。     

Movement segmentation and visual perturbation increase developmental differences in motor control and learning

We examined the developmental differences in motor control and learning of a two‐segment movement. One hundred and five participants (53 female) were divided into three age groups (7–8 years, 9–10 years and 19–27 years). They performed a two‐segment movement task in four conditions (full vision, fully disturbed vision, disturbed vision in the first movement segment and disturbed vision in the second movement segment). The results for movement accuracy and overall movement time show that children, especially younger children, are more susceptible to visual perturbations than adults. The adults’ movement time in one of the movement segments could be increased by disturbing the vision of the other movement segment. The children's movement time for the second movement segment increased when their vision of the first movement segment was disturbed. Disturbing the vision of the first movement segment decreased the percentage of central control of the second movement in younger children, but not in the other two age groups. The children's normalized jerk was more easily increased by visual perturbations. The children showed greater improvement after practice in the conditions of partial vision disturbance. As the participants’ age increased, practice tended to improve their feedforward motor control rather than their feedback motor control. These results suggest that children's central movement control improves with age and practice. We discuss the theoretical implications and practical significance of the differential effects of visual perturbation and movement segmentation upon motor control and learning from a developmental viewpoint.     

高功能孤独症幼儿空间工作记忆的组块加工缺陷

孤独症谱系障碍者存在空间工作记忆加工缺陷,其具体受损环节尚不明确。组块是一种有效的策略性信息编码方式,是空间工作记忆的关键环节。高度结构化的刺激容易形成高水平组块,因此,刺激结构化程度对记忆效果的影响能够反映个体的组块加工能力。研究采用Sternberg空间工作记忆任务、Corsi空间广度任务,加入刺激结构化因素,考察高功能孤独症幼儿是否存在组块加工缺陷,并探讨组块加工是否直接影响到空间工作记忆容量。实验1采用Sternberg空间工作记忆任务,结果表明,ASD幼儿存在明显的组块加工缺陷。在易于组块的高结构化条件下,健康幼儿的记忆成绩明显较高,而ASD幼儿在高、低结构化条件下的记忆成绩并无显著差异。实验2采用Corsi空间广度任务,结果显示,不论高、低结构化条件,ASD幼儿的空间工作记忆容量均显著低于健康幼儿。但ASD幼儿由于存在组块加工缺陷,在高、低结构化条件下的记忆成绩差异较健康幼儿小。因此,ASD幼儿的组块能力一定程度上影响了空间工作记忆容量。此外,记忆存储器的异常可能也是ASD幼儿空间工作记忆容量不足的重要原因。研究表明,ASD幼儿的空间组块缺陷主要由于弱中央统合的认知风格,他们缺乏自上而下的组块加工动机,难以主动对刺激形成高水平组块编码,从而影响记忆效果。