预期错误与急性应激对不同强度恐惧记忆提取消退的影响

在条件性恐惧记忆再巩固模型下, 预期错误被证明是引发记忆不稳定的必要条件, 但其在不同强度恐惧记忆下的作用尚不明确。对于高强度可能导致的提取无效, 缺乏相应的探索以寻找解决办法, 而应激(stress)在其中发挥的作用值得探索。本研究考察人类被试中, 预期错误在不同强度恐惧记忆下的作用, 以及提取之后施加外源性应激对于消退进程的影响。结果发现, 对于较弱的恐惧记忆, 单个预期错误提取后消退可显著抑制恐惧自发恢复; 而对于较强恐惧记忆, 单个预期错误不能提取恐惧记忆进入再巩固, 已消退的记忆还会复发; 且在该种情况下, 如果在提取后施加外源性急性应激, 会进一步增大恐惧恢复。     

错失焦虑与大学生被动性社交网站使用的交叉滞后分析

为探讨大学生错失焦虑与被动性社交网站使用间的准因果关系,采用错失焦虑量表和被动性社交网站使用量表对403名大学生进行间隔8个月的两阶段追踪调查。结果发现：(1)错失焦虑和被动性社交网站使用的自回归路径系数显著,存在风险累积效应。(2)错失焦虑与被动性社交网站使用在8个月内能够互相预测,存在强化螺旋效应。(3)错失焦虑与被动性社交网站使用的交叉滞后效应性别差异不显著,存在跨性别趋同效应。结果支持了强化螺旋模型,表明错失焦虑与大学生被动性社交网站使用能够交互影响。     

师生关系对研究生自我效能感的影响:有调节的中介模型

为探讨师生关系与自我效能感的关系,并着力考察专业认同和导师负面评价恐惧在其中所起的作用,采用一般自我效能感量表、研究生师生关系感知问卷、专业认同量表、害怕导师负面评价量表对458名研究生进行调查,结果发现：（1）师生关系可正向预测研究生自我效能感;专业认同在两者间起中介作用;（2）导师负面评价恐惧在师生关系通过专业认同影响自我效能感的中介模型后半段起调节作用,即对于导师负面评价恐惧较高的研究生来说,专业认同对其自我效能感的影响更大。研究结果揭示了师生关系对自我效能感的作用机制。     

自我关注与社交焦虑：负面评价恐惧的中介与关系型自我构念的调节

为明确自我关注对社交焦虑的影响机制,建构了一个有调节的中介模型,考察负面评价恐惧、关系型自我构念的作用以及性别差异。选取446名大学生进行问卷调查。结果表明：（1）自我关注部分通过负面评价恐惧的中介作用间接预测社交焦虑;（2）关系型自我构念调节中介模型的前半路径：在高关系型自我构念下,自我关注可以显著预测负面评价恐惧;在低关系型自我构念下,该预测作用不显著;（3）有调节的中介模型存在性别差异：在女生群体中,负面评价恐惧的中介效应大于男生群体,且关系型自我构念的调节作用显著;而在男生群体中,该调节效应不显著。     

The contextual malleability of approach-avoidance training effects: approaching or avoiding fear conditioned stimuli modulates effects of approach-avoidance training

Previous research showed that the repeated approaching of one stimulus and avoiding of another stimulus typically leads to more positive evaluations of the former stimuli. In the current study, we examined whether approach and avoidance training (AAT) effects on evaluations of neutral stimuli can be modulated by introducing a regularity between the approach-avoidance actions and a positive or negative (feared) stimulus. In an AAT task, participants repeatedly approached one neutral non-word and avoided another neutral non-word. Half of the participants also approached a negative fear-conditioned stimulus (CS+) and avoided a conditioned safe stimulus (CS?). The other half of the participants avoided the CS+ and approached the CS?. Whereas participants in the avoid CS+ condition exhibited a typical AAT effect, participants in the approach CS+ condition exhibited a reversed AAT effect (i.e. they evaluated the approached neutral non-word as more negative than the avoided non-word). These findings provide evidence for the malleability of the AAT effect when strongly valenced stimuli are approached or avoided. We discuss the practical and theoretical implications of our findings.     

ERP correlates of attentional processing in spider fear: evidence of threat-specific hypervigilance

Attentional bias towards threat can be demonstrated by enhanced processing of threat-related targets and/or greater interference when threat-related distractors are present. These effects are argued to reflect processing within the orienting and executive control networks of the brain respectively. This study investigated behavioural (RT) and electrophysiological correlates of early selective attention and top-down attentional control among females with high (n?=?16) or low (n?=?16) spider fear (Mean age?=?22 years). Participants completed a novel flanker go/nogo task in which a central schematic flower or spider stimulus was flanked by either congruent or incongruent distractors. Participants responded to green stimuli (go trials) and withheld response to yellow stimuli (nogo trials). High fear participants demonstrated significantly shorter reaction times and greater P1 amplitude to spider targets, suggesting specific hypervigilance towards threat-relevant stimuli. In contrast to predictions, there was little evidence for behavioural interference effects or differences in N2 amplitude when distractor stimuli were threat-relevant.     

Is There Savings for Pavlovian Fear Conditioning after Neurotoxic Basolateral Amygdala Lesions in Rats?

Considerable evidence indicates an important role for amygdaloid nuclei in both the acquisition and expression of Pavlovian fear conditioning. Recent reports from my laboratory have focused on the impact of neurotoxic lesions of the basolateral complex of the amygdala (BLA) on conditional freezing behavior in rats. In these studies, I have observed severe effects of posttraining BLA lesions on the expression of conditional freezing even after extensive presurgical overtraining (25-75 trials). Moreover, I have found no evidence for sparing of fear memory (i.e., savings) in these rats when I assess their rate of reacquisition relative to BLA rats receiving minimal training (1 trial). In these experiments, freezing behavior was assessed using a conventional time-sampling procedure and expressed as a response probability. Although this measure is well established in the literature, it is conceivable that it is not sensitive to spared memory in rats with BLA lesions. To address this issue, I present a more detailed analysis of freezing behavior that quantifies latency to freeze, the number of freezing bouts, the duration of freezing bouts, and the probability distribution of bout lengths. I also include control data from untrained (no-shock) rats. Consistent with my earlier reports, I find no evidence of savings of fear memory in rats with neurotoxic BLA lesions using several measures of freezing behavior. These results reiterate the conclusion that fear memory, as it is expressed in freezing behavior, requires neurons in the BLA.     

杏仁体与情绪及感觉功能的关系

近来研究表明杏仁体与感觉、情绪和记忆关系密切。对恐惧条件反射的研究发现杏仁体是情绪活动的关键性结构;导致恐惧条件反射的细胞及分子机制研究征实杏仁体具有情绪学习与记忆机能;杏仁体在向中感觉信息的筛选和凋制中具有显著作用和重要意义。本文将综述这方面的进展。     

Cognitive Bias for Pictorial and Linguistic Threat Cues in Children

The present study was designed to test the conditions under which threat-related cognitive bias can be observed in anxious children. Measures of cognitive bias for threatening words and pictures were obtained from spider fearful children (N = 55) and non-fearful children (N = 58) aged 8–11 in the first experiment, and from spider fearful children (N = 44), and two control groups (N = 41; N = 36) aged 8 in the second experiment. Cognitive bias was assessed by the emotional Stroop task. In line with our previous findings, all children aged 8 showed a bias for spider words, but not for spider pictures. However, a relation between spider fear and bias was observed when age was taken into account: bias for spider words decreased with age in the non-fearful children whereas this bias maintained in the fearful group. This differential age effect too replicated earlier findings (Kindt, Bierman, & Brosschot, 1997). It is suggested that a bias for threat words is a normal characteristic in children aged 8. During development, normal children learn to inhibit this processing bias, whilst fearful children fail to learn this ability.