Accommodating religion to modern neuroscience

Science and religion commonly reside in either an awkward peaceful co-existence or in bitter conflict. That conflict emerges especially in college students as they acquire knowledge about physical, biological, and social sciences. Most college students bring their shallow childhood religious instruction to their college classes. Neuroscience can help students realise how their religious views are affected by their biology, conditioning, experiences, culture, education, emotions, and cognitive processes. In turn, religion can provide world views that challenge neuroscience and remind us of how much remains unknown and may even be unknowable. This report summarises the author’s three semesters’ experience of teaching an upper-division undergraduate essay and discussion course in which students discover how neuroscience and religion inform each other.     

Individual differences in the neural basis of causal inferencing

This study used fMRI to examine individual differences in the neural basis of causal inferencing. Participants with varying language skill levels, as indexed by scores on the vocabulary portion of the Nelson-Denny Reading Test, read four types of two-sentence passages in which causal relatedness (moderate and distant) and presence or absence of explicit clause connectives were orthogonally varied to manipulate coherence and cohesion during inference generation. Skilled readers showed better neural efficiency (less activation) during all context sentences and during all inference conditions. Increased activation in less-skilled readers was most extensively distributed in the right hemisphere (RH) homologues of left hemisphere (LH) language areas, especially in the most difficult passage types. Skilled readers also showed greater sensitivity to coherence (greater activation and synchronization in moderately related than distantly related passages) whereas less-skilled readers showed sensitivity to cohesion (greater activation and synchronization when clause connectives were present than when they were not). These finding support the hypothesis that skilled reading comprehension requires recruitment of the RH on an “as needed” basis. We describe the dynamic spillover hypothesis, a new theoretical framework that outlines the conditions under which RH language contributions are most likely evoked.     

The weight of being: Psychological perspectives on the existential moment

As the prefrontal cortex expanded in human evolution, so too did the capacity for nesting basic biological goals within more complex systems of behavioral organization. This increased ability for abstraction brought with it the challenge of deciding how to interpret the personal significance of any given experience. The human brain appears to manage this increased complexity by defining meaning in relation to one's currently adopted goals. When encountering goal-related information, arousal and exploratory systems become engaged, such that information is processed more thoroughly. As a consequence of this enhanced attention and arousal, neural plasticity is facilitated, allowing motivationally relevant experiences to have a stronger influence on an individual's neural organization. To borrow a gravitational metaphor, the existential weight, or significance, of a particular moment will determine the strength of that moment's influence on an individual's life. Human experience thus appears to be curved around fluctuations in the existential weight of being.     

The duality principle: irreducibility of sub-threshold psychophysical computation to neuronal brain activation

A key working hypothesis in neuroscience is ‘materialistic reductionism’, i.e., the assumption whereby all physiological, behavioral or cognitive phenomena is produced by localized neurochemical brain activation (but not vice versa). However, analysis of sub-threshold Weber’s psychophysical stimulation indicates its computational irreducibility to the direct interaction between psychophysical stimulation and any neuron/s. This is because the materialistic-reductionistic working hypothesis assumes that the determination of the existence or non-existence of any psychophysical stimulation [s] may only be determined through its direct interaction [di1] with a given neuron/s [N] that together forms the ‘neural registry’ computational level [NR/di1]. But, this implies that in cases of (initial) sub-threshold (sensory-specific) psychophysical stimulation which is increased above the sensory-specific threshold but below Weber’s psychophysical ‘dv’—the psychophysical computational processing [PCP] produces an apparently ‘computationally indeterminate’ output. This is because materialistic reductionism asserts the contingency of PCP upon the existence of a direct interaction between ‘s’ and ‘N’ within the NR/di1 level, but in the special case of Weber’s sub-threshold psychophysical stimulation the same PCP/di1 also asserts the non-existence of ‘s’ (as demanded by Weber’s psychophysical law). However, given robust empirical evidence indicating the capability of PCP to determine whether (or not) ‘s’ exists, we must conclude that PCP may not be carried out from within NR’s direct interaction between a particular psychophysical stimulation and any set of neuron/s in the brain. Hence, the Duality Principle asserts the conceptual irreducibility of sub-threshold psychophysical stimulation to any direct NR/di1: s-N interaction, thereby challenging the current materialistic-reductionistic assumption.     

Sexual well-being and perceived stress in couples transitioning to parenthood: A dyadic analysis

Background/ObjectiveThe transition to parenthood encompasses several psychological and relational changes that might contribute to couples’ high levels of stress postpartum. Although common across the postpartum, couples’ sexual changes are frequently overlooked.MethodWe surveyed 255 mixed-sex new parent couples to examine the associations between sexual well-being—sexual satisfaction, desire, and postpartum sexual concerns—and perceived stress postpartum. Couples completed self-report questionnaires assessing perceived stress and sexual well-being.ResultsFor both mothers and fathers, greater sexual satisfaction was associated with their partners’ lower perceived stress and, for fathers, this was also associated with their own lower perceived stress. For mothers, greater partner-focused sexual desire was associated with their own lower perceived stress whereas, for fathers, greater partner-focused sexual desire was associated with their partners’ higher perceived stress. In addition, greater solitary sexual desire and postpartum sexual concerns were associated with both parents’ own higher perceived stress.ConclusionsThis study highlights the association between sexual well-being and couples’ postpartum stress, suggesting that more positive sexual experiences are linked to lower perceptions of stress across this vulnerable period. Couples’ sexual well-being may be an important target for interventions aimed at helping postpartum couples cope with stress.     

Biological perspectives on the effects of early psychosocial experience

There is much current interest in how adverse experiences early in life might affect certain elements of physiological, behavioral, and psychological functioning across the lifespan. Recent conceptual frameworks for studying the effects of early experience have involved constructs such as experience-expectant, experience-dependent, and experience-adaptive plasticity. The latter construct is related to comparative models of developmental programming which posit the persistence of biological adjustments to the early caregiving environment. We briefly review such models and their translational implications. We then turn to human development and focus on the effects of large changes in children’s life courses as tests of hypotheses related to early experience effects. In particular, the effect of early institutionalization on children’s brain and behavioral development after changes to adoptive families or foster care is used as an example of a research area in which programming hypotheses have been proposed.     

Interruption of phonological coding in conduction aphasia

A case study of conduction aphasia, investigating single word repetition, phonological coding, and short-term memory, is reported. Evidence from intact adults suggests that repetition can occur through either a lexical route or a direct auditory-articulatory link. For this conduction aphasic, E.A., the direct link was impaired, although the lexical route could be used to produce accurate single word repetition. Several experiments demonstrated a significant impairment in the generation and maintenance of an abstract phonological code. The consequences of a disruption of phonological coding on speech perception and on verbal short-term memory are discussed.     

Event-related potentials in phonological matching tasks

Two experiments investigated Event-Related Potentials (ERPs) in matching tasks. In Experiment 1 subjects judged, in separate conditions, whether two words rhymed or were written in the same case. The CNV developing between the two words was larger in the latter task compared to the former at the right temporal site. In the rhyme judgment task, an increased late negativity differentiated the ERPs to nonrhyming words from those that rhymed with the previously presented word. This difference was maximal at the midline and over the right hemisphere. Experiment 2 further investigated ERPs in the rhyme judgment task, increasing memory demands with an extended interstimulus interval (ISI) and varying the number of items subjects had to hold in memory during this period (one vs. three). Irrespective of memory load, CNVs during the ISI were more negative from the left hemisphere, and the ERPs to the rhyming and nonrhyming words showed the same differences as in Experiment 1. The CNV asymmetries are interpreted as being associated with the engagement of lateralized short-term memory processes. The rhyme/nonrhyme differences are possibly related to the “N400” component elicited by semantically incongruous words. Possible reasons for their scalp distribution are discussed.     

Using an AI creativity system to explore how aesthetic experiences are processed along the brain’s perceptual neural pathways

With the increased sophistication of AI techniques, the application of these systems has been expanding to ever newer fields. Increasingly, these systems are being used in modeling of human aesthetics and creativity, e.g. how humans create artworks and design products. Our lab has developed one such AI creativity deep learning system that can be used to create artworks in the form of images and videos. In this paper, we describe this system and its use in studying the human visual system and the formation of aesthetic experiences. Specifically, we show how time-based AI created media can be used to explore the nature of the dual-pathway neuro-architecture of the human visual system and how this relates to higher cognitive judgments such as aesthetic experiences that rely on these divergent information streams. We propose a theoretical framework for how the movement within percepts such as video clips, causes the engagement of reflexive attention and a subsequent focus on visual information that are primarily processed via the dorsal stream, thereby modulating aesthetic experiences that rely on information relayed via the ventral stream. We outline our recent study in support of our proposed framework, which serves as the first study that investigates the relationship between the two visual streams and aesthetic experiences.     

Does neuroscience hold promise for the further development of behavior therapy? The case of emotional change after exposure in anxiety and depression

Over the last few years, the integration of biological and psychological models has become increasingly important in clinical psychology. This paper presents a neurobiological framework for exploring how neuroscience research may be valuable in the context of new developments in behavior therapy. The importance of the cortical-subcortical circuitry of emotion processing for investigating the working mechanisms of exposure therapy is illustrated by current neuroimaging research. The implication is that during exposure therapy the focus of attention must be fully directed towards the emotional content of the threatening situation to facilitate prefrontal control over the amygdala and that new contextual information, of emotional salience, must be added to create inhibitory projections from the hippocampus. In addition, some possible mechanisms of action for different therapeutic approaches to both anxiety and depression and the role of neuroimaging techniques in predicting treatment outcome are discussed.