从个体关系的角度看文化对社会脑功能的塑造

摘 要 尽管社会认知的内容丰富多样,但其核心在于人们对“自我”、“他人”及两者关系的理解。文化作为一种独特的社会现象,对社会认知有着广泛影响,这一点集中体现在文化对“自我” 与“他人” 信息加工及其大脑机制的影响上。文化神经科学的研究表明：文化显著影响自我相关记忆、自我表征、自我觉知等自我认知过程。这可能主要来源于不同文化人群自我建构方式的不同。上述差异的神经机制主要体现为不同文化人群自我相关加工时,其内侧前额叶功能性变化的不同。与此相对应的是,文化同样显著影响人们对他人,尤其是对他人情绪的认知。这一点集中表现为表情认知的文化优势效应及共情过程的文化差异。在神经机制上这一差异主要体现为杏仁核功能的文化可塑性。文化神经科学的未来研究,可继续探讨主流文化、区域文化、宗教文化等各种形式的文化差异：1）对自我认知与情绪认知相互作用的影响与神经基础;2）对共情（empathy）、社会比较（social comparison）、心理理论（theory of mind）与协同行为（joint action）等多种社会认知过程的影响及其神经机制。 关键词 自我建构 文化神经科学 情绪认知 自我表征 共情     

光照对小鸡脑内神经细胞粘附分子表达的影响

胚胎发育晚期光照条件的不同,对小鸡后天的学习记忆能力有显著的影响,暗孵化小鸡表现出明显的长时记忆障碍。实验利用免疫组化的方法,分别对光孵化、正常孵化和暗孵化条件下,胚胎发育的第17、18、19、20、21天,小鸡脑内上纹体腹核(HV)中神经细胞粘附分子(NCAMs)的表达进行了观察。结果表明：暗孵化条件下孵出的小鸡,在一次性被动回避学习中,记忆保持水平显著低于光孵化组和正常孵化组;在胚胎发育的第20天NCAM的表达,在光孵化组和正常孵化组中显著增高,到胚胎发育的第21天,这种升高在正常孵化组中显著下降;而暗孵化组在整个观察过程中,NCAM表达水平一直非常低。这一结果提示,不同光照条件在孵化过程中,对NCAM表达的影响,参与了光照对小鸡后天学习记忆行为改变的过程。     

Simple games as dynamic, coupled systems: randomness and other emergent properties

From a game theory perspective the ability to generate random behaviors is critical. However, psychological studies have consistently found that individuals are poor at behaving randomly. In this paper we investigated the possibility that the randomness mechanism lies not within the individual players but in the interaction between the players. Provided that players are influenced by their opponent’s past behavior, their relationship may constitute a state of reciprocal causation [Cognitive Science 21 (1998) 461], in which each player simultaneously affects and is affected by the other player. The result of this would be a dynamic, coupled system. Using neural networks to represent the individual players in a game of paper, rock, and scissors, a model of this process was developed and shown to be capable of generating chaos-like behaviors as an emergent property. In addition, it was found that by manipulating the control parameters of the model, corresponding to the amount of working memory and the perceived values of different outcomes, that the game could be biased in favor of one player over the other, an outcome not predicted by game theory. Human data was collected and the results show that the model accurately describes human behavior. The results and the model are discussed in light of recent theoretical advances in dynamic systems theory and cognition.     

BIOTECHNOTHEOLOGY AND DEMYTHOLOGIZATION OF STEM‐CELL RESEARCH

Biotechnology deals not only with new types of therapies for preventing and curing diseases but also with the creation of new technologies for the production of human flesh. Its ultimate aim is to create a new human body, a new person. Biotechnology wears the cloak not only of a new scientific paradigm but also of a kind of messianic religion. To develop new therapies, to destroy illnesses, to transform the human body into a nonmortal one—these are some of the promises it makes. In time, many of these promises will undoubtedly prove to be illusory, but they will nevertheless continue to have a significant impact on the way people think. Through a process that I call biotechnotheological analysis I show that biotechnology could eventually become not only a type of secular religion but even a type of mythic para‐Christian religion, one that incorporates the two most significant processes at work in every mythical religion: the process of mimesis and the ritual of the scapegoat. The essay is an attempt to understand biotechnological achievements, especially in stem‐cell research, in this new biotechnotheological way.     

胰岛素样生长因子结合蛋白3mRNA在肾癌中的表达

为探讨胰岛素样生长因子结合蛋白3（IGFBP-3）mRNA在肾癌（RCC）中的表达,采用半定量RT-PCR方法进行检测,检测56例RCC组织标本及56例癌旁组织标本中IGFBP-3的表达。结果显示RCC与癌旁组织之间IGFBP-3表达差异有显著性（P〈0.05）,IGFBP-3在透明细胞癌的强阳性表达,高于其他病理类型（P均〈0.05）,并与病理分级相关。因此,IGFBP-3在RCC组织中的表达具有显著性,其在肾透明细胞癌中的强阳性表达具有特异性。     

非小细胞肺癌放疗时机和放疗方式的临床决策

放射治疗是非小细胞肺癌的主要治疗手段之一。大约有3／4的肺癌患者在疾病的不同时期需要做放射治疗。针对不同的患者可以选择根治性放疗、姑息性放疗、术前、术后、放化疗联合治疗等不同的治疗方式。从治疗技术上还可以选择适形、调强、立体定向放疗等。临床医生需要辨证地应用循证医学证据,针对不同的患者刺定合理的个体化治疗方案,以提高疗效。     

免疫反应影响动脉粥样硬化进程的两面性

大量研究表明,动脉粥样硬化的发生和发展过程中,能观察到许多免疫反应。然而,免疫反应对动脉粥样硬化的作用却呈现为两面性;免疫系统的激活可加速动脉粥样硬化的形成和发展,也可表现出抗动脉粥样硬化功效。所以,适当的免疫调节干预,有望成为动脉粥样硬化的预防及治疗的新途径。     

胰岛细胞再生研究的临床应用前景

胰岛细胞再生是治愈1型糖尿病和胰岛β细胞功能丧失的2型糖尿病的根本途径。体外再生和体内再生两种策略都是通过将干细胞或其他类型体细胞分化或转化为胰岛细胞后发挥胰岛素分泌功能,从而治疗糖尿病。基础研究显示,两者存在着各自的优势和面临的问题。胰岛细胞再生治疗的临床应用前景尚需要进一步加以考证。     

Re-framing the characteristics of concepts and their relation to learning and cognition in artificial agents

In this work, the problems of knowledge acquisition and information processing are explored in relation to the definitions of concepts and conceptual processing, and their implications for artificial agents.The discussion focuses on views of cognition as a dynamic property in which the world is actively represented in grounded mental states which only have meaning in the action context. Reasoning is understood as an emerging property consequence of actions-environment couplings achieved through experience, and concepts as situated and dynamic phenomena enabling behaviours.Re-framing the characteristics of concepts is considered crucial to overcoming settled beliefs and reinterpreting new understandings in artificial systems.The first part presents a review of concepts from cognitive sciences. Support is found for views on grounded and embodied cognition, describing concepts as dynamic, flexible, context-dependent, and distributedly coded.That is argued to contrast with many technical implementations assuming concepts as categories, whilst explains limitations when grounding amodal symbols, or in unifying learning, perception and reasoning.The characteristics of concepts are linked to methods of active inference, self-organization, and deep learning to address challenges posed and to reinterpret emerging techniques.In a second part, an architecture based on deep generative models is presented to illustrate arguments elaborated. It is evaluated in a navigation task, showing that sufficient representations are created regarding situated behaviours with no semantics imposed on data. Moreover, adequate behaviours are achieved through a dynamic integration of perception and action in a single representational domain and process.     

The influence of asymmetric force requirements on a multi-frequency bimanual coordination task

An experiment was designed to determine the impact of the force requirements on the production of bimanual 1:2 coordination patterns requiring the same (symmetric) or different (asymmetric) forces when Lissajous displays and goal templates are provided. The Lissajous displays have been shown to minimize the influence of attentional and perceptual constraints allowing constraints related to neural crosstalk to be more clearly observed. Participants (N = 20) were randomly assigned to a force condition in which the left or right limb was required to produce more force than the contralateral limb. In each condition participants were required to rhythmically coordinate the pattern of isometric forces in a 1:2 coordination pattern. Participant performed 13 practice trials and 1 test trial per force level. The results indicated that participants were able to effectively coordinate the 1:2 multi-frequency goal patterns under both symmetric and asymmetric force requirements. However, consistent distortions in the force and force velocity time series were observed for one limb that appeared to be associated with the production of force in the contralateral limb. Distortions in the force produced by the left limb occurred regardless of the force requirements of the task (symmetric, asymmetric) or whether the left or right limb had to produce more force than the contralateral limb. However, distinct distortions in the right limb occurred only when the left limb was required to produce 5 times more force than the right limb. These results are consistent with the notion that neural crosstalk can influence both limbs, but may manifest differently for each limb depending on the force requirements of the task.