Positive and negative affect,depression, and cognitive processes in the Cognition in the Study of Tamoxifen and Raloxifene (Co-STAR) Trial

ABSTRACT

Objectives: This study examined the relationship between positive and negative affect, depressive symptoms, and cognitive performance. Methods: The sample consisted of 1479 non-demented, postmenopausal women (mean age = 67 years) at increased risk of breast cancer enrolled in the National Surgical Adjuvant Breast and Bowel Project’s Study of Tamoxifen and Raloxifene. At each annual visit, women completed a standardized neuropsychological battery and self-report measures of affect and depression. Data from three visits were used in linear mixed models for repeated measures using likelihood ratio tests. Separate analyses were performed to relate positive/negative affect and depression to each cognitive measure. Results: Higher positive affect was associated with better letter fluency (p = .006) and category fluency (p < .0001). Higher negative affect was associated with worse global cognitive function (p < .0001), verbal memory (CVLT List B; p = .002), and spatial ability (p < .0001). Depressive symptoms were negatively associated with verbal knowledge (p = .004), figural memory (p < .0001), and verbal memory (p’s ≤ .0001). Discussion: Findings are consistent with some prior research demonstrating a link between positive affect and increased verbal fluency and between depressive symptoms and decreased memory. The most novel finding shows that negative affect is related to decreased global cognition and visuospatial ability. Overall, this research in a large, longitudinal sample supports the notion that positive affect is related to increases and negative affect to decreases in performance on distinct cognitive measures.     

On the origin of happiness by means of natural felicitation

The present study tested theoretical models of the forgivingness – well-being association with depression symptoms and social justice commitment as outcome measures and with differentiation of self (DoS) and dispositional humility as mediators. In doing so, we addressed the need to explicitly frame the study of virtues in a relational view of the self and extended the research on forgivingness and humility that moves beyond a focus on personal benefit and attends to the ways in which virtues also benefit other persons. The sample consisted of 213 graduate students from a religiously-affiliated university who completed a questionnaire of self-report measures. Results supported the proposed models as significant specific indirect effects were observed through DoS and humility. The findings support a self-regulating mechanism, as measured by DoS and dispositional humility, for the protective influence of forgivingness on depression symptoms and the promotive influence of forgivingness on prosocial relating.     

On the confluence of optimism and hope on depressive symptoms in primary care patients: Does doubling up on bonum futurun Proffer any added benefits?

A model involving optimism and hope as predictors of depressive symptoms was tested in a sample of 28 male and 67 female primary care patients. Beyond the distinct influence of the two predictors on depressive symptoms, optimism and hope were also hypothesized to interact together to predict depressive symptoms. Results of a regression analysis indicated that, independent of demographic variables (viz. age, sex, race/ethnicity, marital status, and educational level), optimism and hope were significant and unique predictors of depressive symptoms in adults. Noteworthy, beyond optimism and hope, the Optimism?×?Hope interaction term was found to significantly augment the prediction of depressive symptoms. Some implications of the present findings are discussed.     

Variations in selective and nonselective prediction error with the negative dimension of schizotypy

Two human associative-learning experiments investigated the relationship between the negative dimension of schizotypy and selective and nonselective prediction-error learning. Experiment 1 demonstrates that individuals low, but not high, on the introvertive anhedonia dimension of schizotypy demonstrate Kamin blocking, which has been taken to reflect the operation of selective learning (Rescorla & Wagner, 1972). In complement, Experiment 2 demonstrates that individuals high, but not low, on the same dimension demonstrate asymmetrical learning about the components of a compound stimulus that differ in their associative history, which has been suggested to reflect the operation of nonselective learning (Rescorla, 2000). The implications of this double dissociation for understanding the nature of the cognitive deficit in schizophrenia and for theories of learning are considered.     

Negative priming of unattended part primes: Implications for models of holistic and analytic processing in object recognition

The “hybrid” model of object recognition (Hummel, 2001) proposes that unattended objects are processed holistically, while attended objects are processed both holistically and analytically. Supporting evidence for this claim was reported by Thoma, Hummel, and Davidoff (2004) who showed that, unlike whole object primes, unattended split object parts (presumed to require analytic processing) do not elicit repetition priming. Here we tested the generality of this finding by contrasting priming for whole and part prime stimuli as a function of prime informativeness and by modifying the design so that both unattended whole and part prime displays contained a single perceptual object. Unlike Thoma et al. (2004) the results showed negative (rather than an absence of) priming for unattended half object primes. These findings place new constraints on theoretical models of the role of attention in object recognition.     

Negative numbers in simple arithmetic

Are negative numbers processed differently from positive numbers in arithmetic problems? In two experiments, adults (N?=?66) solved standard addition and subtraction problems such as 3?+?4 and 7 – 4 and recasted versions that included explicit negative signs—that is, 3 – (–4), 7?+?(–4), and (–4)?+?7. Solution times on the recasted problems were slower than those on standard problems, but the effect was much larger for addition than subtraction. The negative sign may prime subtraction in both kinds of recasted problem. Problem size effects were the same or smaller in recasted than in standard problems, suggesting that the recasted formats did not interfere with mental calculation. These results suggest that the underlying conceptual structure of the problem (i.e., addition vs. subtraction) is more important for solution processes than the presence of negative numbers.     

Processing negative numbers by transforming negatives to positive range and by sign shortcut

Numerals are processed by a phylogenetically old analogue magnitude system. Can culturally new negative numerals be processed using this same representation? To find out whether magnitude representation could be used, we contrasted three possible processing mechanisms: an extended magnitude system for both positive and negative numbers, a mirroring mechanism that could transform negative values to the positive range to be processed on the positive magnitude system, and a sign shortcut strategy that can process the signs of numbers independently of the absolute values of numerals. To test these three hypotheses, a comparison task was used and the reaction time pattern, numerical distance, and Spatial-Numerical Association of Response Codes (SNARC) effect was analysed. The results revealed a mirroring process along with a sign shortcut mechanism. The SNARC effect was observed only when positive numbers were compared.     

Psychosocial Characterization of Physically Abused Children from Low Socioeconomic Households in Comparison to Neglected and Nonmaltreated Children

Research reports on the long-term sequelae of physically abused children have not produced a coherent profile that can be used to identify this population as a distinct diagnostic group. To define the specific combination of symptomatology and personality characteristics of this group, 41 physically abused children, referred by the state Child Protection Officers were interviewed using the Attachment Style Classification Questionnaire, the Children's Depression Inventory, the Trait Anxiety Inventory, and the Child Suicidal Potential Scales. The results were compared with those of 38 neglected children and 35 nonabused, nonneglected children. The physically abused children showed an avoidant attachment style, specific depressive and suicidal symptomatology, high anxiety level, high aggression level, and primitive defense mechanisms. A discriminant data analysis identified 92.8% of the participants in terms of their diagnostic status. Our study suggests that an emotional and behavioural cluster of characteristics may differentiate physically abused children from neglected and nonmaltreated children. This cluster highlights the severity of induced developmental damages in the short and long-term.     

Dysmorphic concern and behavioural impairment related to body image in adolescents

This study examined a moderated mediation model testing whether dysmorphic concern is related to behaviour altered to change appearance. This relationship is potentially mediated by depressive symptomatology (dysphoria and self-esteem) and ideas of reference about “laughing, commenting” and “attention, appearance,” and each mediated relationship moderated by sex. The sample was made up of 3377 adolescents from 12 to 18 years old (M_age = 14.52; SD = 1.65, 56.5% girls). The results showed that dysphoria and ideas of reference about “laughing, commenting” and “attention, appearance” partially mediated the relationship between dysmorphic concern and behavioural impairment related to body image. The relationship with dysphoria was moderated by sex, such that the mediation effect was stronger in girls than in boys. This result implies that girls who are worried about some characteristic of their appearance and show dysphoria are at greater risk of altered behaviour involving avoidance or controlling their appearance than boys. In addition, a possible risk of body dysmorphic disorder (3.45% of the sample) was found, with very prominent hiding behaviour using clothing or control behaviours, such as frequent weighing and looking at oneself in the mirror too much. Implications of these findings are discussed.