负性生活事件对大学生抑郁的影响：网络成瘾的中介与5-HTR1A基因rs749098多态性的调节作用

基于抑郁的基因-环境研究范式,以301名大学生为研究对象,探究负性生活事件对大学生抑郁的影响及作用机制。结果表明：(1)负性生活事件、网络成瘾与大学生抑郁两两显著相关;(2)网络成瘾在负性生活事件对大学生抑郁的影响中起部分中介作用;(3) 5-HTR1A基因rs749098多态性在该中介模型的直接路径和中介后半段起调节效应,具体表现为,相比携带C/G和G/G基因型个体,C/C基因型个体负性生活事件对抑郁的负向预测更强,且携带C/C基因型的个体,即使是低水平的网络成瘾的都表现出更高的抑郁情况,而在高水平的网络成瘾的情况下三种基因型都表现出高水平的抑郁。     

Does childhood general cognitive ability at age 12 predict subjective well-being at age 52?

Drawing on a broad, multidimensional conceptualization of subjective well-being, this study examined the power of childhood general cognitive ability to predict life satisfaction, satisfaction with eight individual life domains, and the frequency of experiencing positive and negative affect in middle adulthood. Data were obtained from a representative Luxembourgish sample (N = 738; 53% female) in a longitudinal study conducted in 1968 and 2008. Childhood general cognitive ability was unrelated to life satisfaction, negatively related to negative affect and satisfaction with free time, and positively related to positive affect and satisfaction with some of the life domains associated with socioeconomic success (i.e. finances, self, housing, work, or health). This predictive power persisted even when childhood socioeconomic status was controlled.     

How the brain responds to any: an MEG study

The word any may appear in some sentences, but not in others. For example, any is permitted in sentences that contain the word nobody, as in Nobody ate any fruit. However, in a minimally different context any seems strikingly anomalous: ^*Everybody ate any fruit. The aim of the present study was to investigate how the brain responds to the word any in such minimally different contexts - where it is permitted (licensed) and where it is not permitted (unlicensed). Brain responses were measured from adult readers using magnetoencephalography (MEG). The results showed significantly larger responses to permissible contexts in the left posterior temporal areas between 400-500 ms and 590-660 ms. These results clarify the anatomy and timing of brain processes that contribute to our judgment that a word such as any is or is not permitted in a given context.     

Exploring the unique and interactive roles of distress tolerance and negative urgency in obsessions

Recent research has implicated relationships between emotion dysregulation and obsessions. Evidence suggests low distress tolerance and greater tendency to act impulsively in the face of negative affect (or negative urgency) are strongly related to obsessions. The current study sought to examine the unique and interactive roles of distress tolerance and negative urgency in the prediction of obsessions. A large non-clinical sample (N = 238) was administered a range of self-report measures. Results revealed that both poor distress tolerance and greater negative urgency were uniquely associated with obsessions but not other obsessive-compulsive symptoms, even when controlling for gender, depression, anxiety, and generalized anxiety disorder symptoms. Additionally, low distress tolerance and high negative urgency interacted with each other in the prediction of greater obsession symptoms. Overall, the findings help clarify the emerging literature linking emotion dysregulation to obsessions.     

The effects of negative affectivity on self-reported activity limitations in stroke patients: Testing the Symptom Perception,Disability and Psychosomatic Hypotheses

This study investigated whether Negative Affectivity (NA) causes bias in self-report measures of activity limitations or whether NA has a real, non-artifactual association with activity limitations. The Symptom Perception Hypothesis (NA negatively biases self-reporting), Disability Hypothesis (activity limitations cause NA) and Psychosomatic Hypothesis (NA causes activity limitations) were examined longitudinally using both self-report and objective activity limitations measures. Participants were 101 stroke patients and their caregivers interviewed within two weeks of discharge, six weeks later and six months post-discharge. NA and self-report, proxy-report and observed performance activity (walking) limitations were assessed at each interview. NA was associated with activity limitations across measures. Both the Disability and Psychosomatic Hypotheses were supported: initial NA predicted objective activity limitations at six weeks but, additionally, activity limitations at six weeks predicted NA at six months. These results suggest that NA both affects and is affected by activity limitations and does not simply influence reporting.     

How people make decisions about predictive genetic testing: An analogue study

Abstract

Persons scoring high on negative affectivity (NA) have more subjective health complaints. In this study, we tested the hypothesis that high NA persons are more likely to experience internal sensations as threatening signs of health problems. Low and high NA participants (N=44) were given four breathing trials: one room air trial followed by three trials containing 5.5% CO₂ which induced transient low intensity somatic sensations. Prior to each CO₂ trial, participants received either positive, negative or uncertain labelings of the sensations that might occur. Participants rated the (un)pleasantness of the experienced somatic sensations and the perceived intensity. Also respiratory responses were measured. During CO₂ trials, reliable main effects of information were found but no effects involving NA were observed, neither on pleasantness ratings nor on respiratory responses. However, during room air breathing, high NA participants reported more intense somatic sensations than low NA participants. Post-experimental data suggested that high NA participants had more negative meanings and worries about the consequences of the physical sensations. It is concluded that interpretational biases in high NA is situated at the level of attributional processes.     

Negative affectivity,coping, immune status,and disease progression in hiv iwected individuals

Abstract

The primary goal of the study was to assess the relationship between personality dispositions, coping styles, immune markers, clinical status, and subjective somatic symptoms in a mixed sample of HIV positive individuals. Specifically, the prognostic value of psychological and immunological measures in HIV progression was emphasized. Subjects (n = 104) were recruited from a cohort of 422 HIV positive individuals enrolled in the Oslo HIV Cohort Study. The partkipants were given self-administered questionnaires assessing behavioral, psychological, and psychdal variables. Clinical assessment and immunological tests were performed at regular follow-up visits. Clinical status was assessed according to the Centers for Disurse Control criteria. The immune markers used were CD4 T cell counts, beta2-microglobulin concentration, sewn levels of HIV-1 p24 core protein, and levels of antibodies to core protein. In addition, subjective somatic symptoms were assessed.

The results showed that measure-s of negative affectivity (NA; e.g. anxiety, distress, tension) were consistently related to subjective somatic symptoms and passivedefensive coping style. However, no amistent association between NA measures and immune markers was found. Individuals who developed AIDS in the study period had significantly lower initial CD4 cell counts as well as lower scores on measures of active-pmblem related wping (e.g. Positive reappraisal, Seeking social support) and passivedefensive coping (i.e. Escape-Avoidance, Self-control).

The results suggest (1) that coping styles may merit a specific focus in future research of psychological factors and medical outcomes in HIV infection, and (2) because of associations of NA measures with symptom reports studies of the relationship between e.g. stress, depression and HIV outcome should consider these variables as confounders.     

Temperament and negative semantic priming in children 7 to 12 years old

The present research assessed whether children with high and low scores on temperament traits differed in their ability to inhibit irrelevant task information in a lexical decision task. Children from 7 to 12 years old were classified based on temperament dimensions measured using a version of the Temperament in Middle Childhood Questionnaire. The participants were instructed to either attend to (and remember) or to ignore a masked prime word followed by a central probe target on which they made a lexical decision. The results revealed several notable outcomes. First of all, recognition memory was better for attended than ignored words, providing further evidence that attention instructions influenced the processing of the primes.

Secondly, although no negative priming effect was obtained in the “ignore” condition, 43% of children showed this effect. Thirdly, children scoring high on Inhibitory Control and Impulsivity showed ignored negative priming, whereas children scoring high on Inhibitory Control and low on Impulsivity ignored facilitation. Data are discussed within the framework of negative priming as a complex phenomenon that involves the interaction of different factors such as age, type of task, and certain temperament traits.     

Negative,zero and positive stiffness in extended Eshelby plates

Structures under loading can show positive and negative stiffness (during buckling) with zero stiffness just being one point of transition. Material structures with extended zero stiffness regimes have also been reported. Using the example of an extended Eshelby plate with a positive and negative edge dislocation, we show the existence of finite regimes of positive, zero and negative stiffness in a single system. Given that stable states/configurations of negative stiffness cannot exist in an isolated system; we show the existence of metastable states of negative stiffness along with unstable states of positive stiffness. The system also exhibits one point of unstable equilibrium.     

Positive affectivity and attentional control moderate the link between negative affectivity and depressed mood

Research and theory suggest that deficits in trait positive affectivity (PA) and in capacity for executive control of attention (i.e., attentional control or AC) may each intensify risk for depressive symptoms associated with high trait negative affectivity (NA). In contrast, high levels of PA and AC should protect against that risk. However, prospective tests of such predictions are rare. Furthermore, if PA and AC both modulate NA-related risk, it remains to be seen if those effects are independent and complementary or if they operate in an overlapping manner. This study assessed baseline temperament and change in depressed mood across one month in a sample of 125 adolescents. Results supported both PA and AC as modulators of NA’s association with changes in depressed mood. Furthermore, results suggested that these modulating effects are largely non-overlapping and complementary, such that when both PA and AC are low, high NA predicts increases in depressed mood. In contrast, high NA predicts decreases in depressed mood when both PA and AC are high. Limitations of these findings, directions for future research, and implications for prevention are discussed.