Knowledge of Breast Cancer Genetics Among Breast Cancer Patients and First-Degree Relatives of Affected Individuals

The cloning of BRCA1, a susceptibility gene for inherited breast cancer, has made genetic screening possible for individuals and families whose medical histories are suggestive of an inherited predisposition to breast cancer. To date, few systematic attempts have been made to determine the level of knowledge about breast cancer genetics among women who are likely to seek BRCA1 screening when it becomes widely available. The present study attempted to assess the general knowledge about BRCA1 mutations in two groups: (1) first-degree relatives (FDRs) of breast cancer patients; and (2) women with a previous diagnosis of breast cancer. A self-administered, thirty-item questionnaire was developed through a pilot study. Ten of the items were objective, factual questions about breast cancer genetics. Responses to these questions were used to generate an overall knowledge score for each respondent. The study population was moderately knowledgeable about breast cancer genetics, with an average score of 5.35 out of 10. Counselors should not underestimate the importance of evaluating each counselee's existing knowledge about breast cancer, which can affect the provision and reception of genetic information. In particular, specific areas of knowledge that may be confusing or misunderstood were identified and these topics are discussed in detail.     

The Conditions of Philosophy in Totalitarian and Post-Totalitarian Poland

This compound paper presents the views of two Polish philosophers on the strong international pressures influencing the development of Polish philosophy in recent times. The first part, by Leszek Koczanowicz, treats the philosophical situation and problems of totalitarian Poland under the influence of Soviet Marxism, while the second part, by Adam Chmielewski, focuses on the main trends and difficulties of post-totalitarian Poland, dominated by Western influence.     

Passport to Duke

Editor’s Introduction The following text was prepared by Pierre Bourdieu for delivery at a conference on his work held at Duke University, April 21–23, 1995. Entitled “Pierre Bourdieu: Fieldwork in Culture,” the conference was sponsored by the Duke Graduate Program in Literature and included such well-known literary scholars as Barbara Herrnstein Smith, Jonathan Culler, and Fredric Jameson. Bourdieu, of course, was the invited guest of honor, but was uncertain as to whether he should make the effort of attending, particularly since he was recovering from a short period of poor health. As I too had been invited (and seemed more familiar with the American scene), Bourdieu discussed the question with me in Paris. He was rather concerned about wrongheaded, trendy applications of his theories by American literary scholars, who often misunderstand his work because they simply do not know the intellectual landscape to which it relates. Reading such conference paper titles as “Cross-Dressing for Success: The Scramble for Symbolic Power in Tabitha Sweeney’s Female Quixotism,” Bourdieu confessed his fear of being taken as simply the French intellectual flavor of the month, one whose theory is used simply as grist for the American academy’s industrious mills of literary interpretation. He ultimately decided to send the following text to be read at the conference in his absence. It treats, with polite frankness, his worries about being misinterpreted through importation into the American theoretical field with its peculiar conception of French philosophy; Bourdieu’s paper situates these particular worries within a more general account of “allodoxic”distortions caused by the international travel of theory; but it also tries to prevent further misunderstanding by offering a brief contextualization of his theory and a brief summary of his method of analysis through fields. The translation of Bourdieu’s text was prepared by Loïc Wacquant, and is presented here with only minor adjustments.     

Psychophysiological arousal related to Type A components in adolescent boys

The association between psychophysiological responses (heart rate, skin conductance and blood volume) and Type A behavior was studied in adolescent boys (n = 48) in computer-controlled experiments. Although psychophysiological arousal was related to the type of stress-evoking element, task-specificity did not result in significant psychophysiological differences between Type As and Nontype As. The indication is that physiological arousal may be a constitutional characteristic of Type A behavior. The multidimensionality of type A behavior must be considered in any investigation examining the psychophysiological Type A-Nontype A differences. Different Type A dimensions, together with previously found psychological differences, were related to specific psychophysiological reactions.     

Non-empirical and empirical components in the hypotheses of five social psychological experiments

Five studies published in the Journal of Experimental Social Psychology and selected without advance knowledge of their contents, were analyzed with respect to the epistemic and modal status of their hypotheses. It was found that the general hypotheses were a priori and noncontingent (necessarily true), whereas the local auxiliary hypotheses were empirical and contingent. Hence, the data were only relevant for the latter. It is conjectured that such pseudoempirical studies may abound in contemporary psychology. They remain undiscovered because researchers unreflectively believe that all propositions that can be related to data are empirical and that psychological terms need not be defined. Only when terms are defined and presuppositions (axioms) are stated, can one determine the epistemic and modal status of a given proposition, and, hence, whether or not a study is pseudoempirical.     

Regulate to facilitate: A scoping review of prefrontal asymmetry in sport and exercise

BackgroundPrefrontal asymmetry (PFA) describes the relative activity of the right PFC compared to the left PFC. It has been shown that PFA is associated with affective and motivational variables in several contexts, including sport and exercise. Considering the significant roles of affect and motivation in different performance settings, PFA might also be an important indicator of athletic performance. However, the relevance of PFA in the sport and exercise setting has not yet been addressed in its entirety. Instead, previous systematic reviews have solely focused on affective variables. Mapping out the complex interactions between PFA and affective, motivational as well as performance variables could help to understand what determines successful athletic performance as well as the positive psychological effects associated with exercise.ApproachScientific databases were searched for quantitative studies in English language published in international peer-reviewed journals. All 27 selected studies assessed physical activity and measured PFA in the brain locations F4-F3 and/or F8-F7 using electroencephalography.FindingsThe majority of the studies used a non-athlete sample (78%) and exercise types were diverse. While all studies focused on affective or motivational processes, 19% also reported associations with performance. Even though findings are inconsistent, they support the assumption that PFA plays a role in self-regulation.ConclusionThere is evidence for an involvement of PFA in affective, motivational and performance processes in the sport and exercise setting that can be interpreted as regulatory mechanisms. Future research on the underlying mechanisms is warranted, in particular, associations with motivational processes and performance need to be investigated more explicitly.     

Game logic and its applications I

This paper provides a logic framework for investigations of game theoretical problems. We adopt an infinitary extension of classical predicate logic as the base logic of the framework. The reason for an infinitary extension is to express the common knowledge concept explicitly. Depending upon the choice of axioms on the knowledge operators, there is a hierarchy of logics. The limit case is an infinitary predicate extension of modal propositional logic KD4, and is of special interest in applications. In Part I, we develop the basic framework, and show some applications: an epistemic axiomatization of Nash equilibrium and formal undecidability on the playability of a game. To show the formal undecidability, we use a term existence theorem, which will be proved in Part II.The authors thank Hiroakira Ono for helpful discussions and encouragements from the early stage of this research project, and Philippe Mongin, Mitio Takano and a referee of this journal for comments on earlier versions of this paper. The first and second authors are partially supported, respectively, by Tokyo Center of Economic Research and Grant-in-Aids for Scientific Research 04640215, Ministry of Education, Science and Culture.Presented by H. Ono     

Calibration of probability assessments by professional blackjack dealers, statistical experts, and lay people

The question addressed in this study is whether experts are better calibrated than lay people. We investigated how well people are calibrated when they assess the probabilities of card combinations in the game of blackjack. Three groups of subjects were used: professional dealers, statistical experts, and control subjects. The results showed that experience and statistical expertise do not make people better calibrated in this task. It is argued that the concept of calibration is not wholly appropriate to describe the obtained deviations from the normatively correct responses. This is illustrated by a discriminant analysis performed on the signed deviation scores, which resulted in an almost perfect separation of the three groups, although they were overlapping with respect to calibration.