The Complex Interplay Between Trait Fatigue and Cognition in Multiple Sclerosis

Cognitive impairments are frequent in patients with Multiple Sclerosis (MS). Yet, the influence of MS-related symptoms on cognitive status is not clear. Studies investigating the impact of trait fatigue along with anxio-depressive symptoms on cognition are seldom, and even less considered fatigue as multidimensional. Moreover, these studies provided conflicting results.Twenty-nine MS patients and 28 healthy controls, matched on age, gender and education underwent a full comprehensive neuropsychological assessment. Anxio-depressive and fatigue symptoms were assessed using the HAD scale and the MFIS, respectively. Six composite scores were derived from the neuropsychological assessment, reflecting the cognitive domains of working memory, verbal and visual learning, executive functions, attention and processing speed. Stepwise regression analyses were conducted in each group to investigate if trait cognitive and physical fatigue, depression and anxiety are relevant predictors of performance in each cognitive domain. In order to control for disease progression, patient’s EDSS score was also entered as predictor variable.In the MS group, trait physical fatigue was the only significant predictor of working memory score. Cognitive fatigue was a predictor for executive functioning performance and for processing speed (as well as EDSS score for processing speed). In the healthy controls group, only an association between executive functioning and depression was observed.Fatigue predicted cognition in MS patients only, beyond anxio-depressive symptoms and disease progression. Considering fatigue as a multidimensional symptom is paramount to better understand its association with cognition, as physical and cognitive fatigue are predictors of different cognitive processes.     

P-technique factor analyses of the Multiple Affect Adjective Check List (MAACL)

The Multiple Affect Adjective Check List (MAACL) has been found to have five first-order factors representing Anxiety, Depression, Hostility, Positive Affect, and Sensation Seeking and two second-order factors representing Positive Affect and Sensation Seeking (PASS) and Dysphoria. The present study examines whether these first- and second-order conceptions of affect (based on R-technique factor analysis) can also account for patterns of intraindividual variability in affect (based on P-technique factor analysis) in eight elderly women. Although the hypothesized five-factor model of affect was not testable in all of the present P-technique datasets, the results were consistent with this interindividual model of affect. Moreover, evidence of second-order (PASS and Dysphoria) and third-order (generalized distress) factors was found in one data set. Sufficient convergence in findings between the present P-technique research and prior R-technique research suggests that the MAACL is robust in describing both inter- and intraindividual components of affect in elderly women.This paper is based on the doctoral research of the first author and was partially supported by the National Institute of Aging Grant T32 AC 00048-12 to The Pennsylvania State University and a Grant-in-Aid of Research from Sigma Xi, The Scientific Research Society. The authors wish to thank John R. Nesselroade for his helpful comments on an early draft of this paper.     

Discriminant validity of the Multiple Affect Adjective Check List - revised

Four groups of patients (depressives, schizophrenics, substance dependents and abusers), a miscellaneous group of other patients, and a group of matched normals from a general population sample were compared on the scales of the Multiple Affect Adjective Check List - Revised (MAACL-R). All scales showed highly significant differentiation among the groups. An index consisting of Depression minus Positive Affect scales was particularly effective in discriminating between depressive and other groups. A discriminant function analysis showed that the depressive could be distinguished from other patient groups and normals with an accuracy of 72% correct. The normals could be distinguished from all of the patient groups with a 60% accuracy, and 87% if the substance abuser group is ignored. The discriminant validity among the nondepressive patient groups was not nearly as good.     

Promoting peace in engineering education: Modifying the ABET criteria

Modifications to the ABET Criterion 3 are suggested in support of the effort to promote the pursuit of peace in engineering education. The proposed modifications are the result of integrating the United Nations’ sponsored “Integral Model of Education for Peace, Democracy and Sustainable Development” into the modern engineering curriculum. The key elements of the model are being at peace with oneself, being at peace with others, and being at peace with the planet. In addition to proposing modifications, specific classroom activities are described and implemented, and students’ reactions and the effectiveness of the various exercises are discussed. An earlier version of this paper was presented at the 2005 conference, Ethics and Social Responsibility in Engineering and Technology, Linking Workplace Ethics and Education, Los Angeles, California, USA, 9–10 June 2005.     

Enumeration versus multiple object tracking: the case of action video game players

Here, we demonstrate that action video game play enhances subjects' ability in two tasks thought to indicate the number of items that can be apprehended. Using an enumeration task, in which participants have to determine the number of quickly flashed squares, accuracy measures showed a near ceiling performance for low numerosities and a sharp drop in performance once a critical number of squares was reached. Importantly, this critical number was higher by about two items in video game players (VGPs) than in non-video game players (NVGPs). A following control study indicated that this improvement was not due to an enhanced ability to instantly apprehend the numerosity of the display, a process known as subitizing, but rather due to an enhancement in the slower more serial process of counting. To confirm that video game play facilitates the processing of multiple objects at once, we compared VGPs and NVGPs on the multiple object tracking task (MOT), which requires the allocation of attention to several items over time. VGPs were able to successfully track approximately two more items than NVGPs. Furthermore, NVGPs trained on an action video game established the causal effect of game playing in the enhanced performance on the two tasks. Together, these studies confirm the view that playing action video games enhances the number of objects that can be apprehended and suggest that this enhancement is mediated by changes in visual short-term memory skills.     

Construct validity of a personality assessment game in a simulated selection situation and the moderating roles of the ability to identify criteria and dispositional insight

There is scant research on the validity of personality assessment games in selection situations. Therefore, in two experimental simulated selection studies, the construct validity of an assessment game developed to assess honesty-humility was tested. Both studies found no differences between a control condition and a simulated selection condition on honesty-humility game scores. Moreover, convergent and discriminant validity with self-reported personality were not affected by the manipulation. We obtained mixed evidence that individual differences in dispositional insight and the ability to identify criteria influenced the validity of the game. As the validity of the personality assessment game was not significantly affected in the simulated selection context, our findings may imply that well-designed personality assessment games can be used for high-stakes selection assessments.     

Reflections on peer review practices in committees selecting laureates for prestigious awards and prizes: Some relevant and irrelevant criteria

An important function in all scholarly and academic activities is the participation in the peer review system. One aspect of this peer review evaluation is service on committees judging candidates for important awards, prizes and fellowships. Some reflective observations on this process are made in which a number of factors determining the final choice are identified. It is pointed out that the decisions of such committees are based not only on relevant and objective criteria but are also influenced by a number of irrelevant criteria; caution must be exercised to minimize the effect of the latter factors in order to maintain the highest ethical standards in the selection process. The ranking practices of awards committees, national academies and learned societies are briefly reviewed by pointing out some ethical pitfalls, anecdotal incidents, and the ways to avoid the tarnishing of the selection process. Dr. Vijh is a physical chemist whose research interests include interfacial electrochemistry and the chemical physics of solid surface s.     

ACCEPTABILITY CRITERIA FOR WORK IN THEOLOGY AND SCIENCE

Abstract. The philosophy of science of Imre Lakatos suggests criteria for acceptability of work in the interdisciplinary area of theology and science: proposals must contribute to scientific (or theological) research programs that lead to prediction and discovery of novel facts. Lakatos's methodology also suggests four legitimate types of theology–and–science interaction: (1) heuristic use of theology in science; (2) incorporation of a theological assertion as an auxiliary hypothesis in a scientific research program, or (3) as the central theory of a research program; and (4) hybrid theology–and–science programs with empirical data. Three recent Zygon articles illustrate these four types.     

Broad or narrow affect scores for the Multiple Affect Adjective Check List? Comment on Hunsley's “dimensionality of the Multiple Affect Adjective Check List-Revised”

Hunsley's paper constitutes the second independent replication of four of the five factors in the Multiple Affect Adjective Check List-Revised (MAACL-R), even though he used the trait instead of the state form used to construct the scales and a more stringent factor loading criterion than Zuckerman and Lubin. Hunsley also did a two-factor analysis (positive and negative affects) of the MAACL items and concluded on the basis of the scree test that this was a more optimal solution than the five-factor one. This conclusion is questioned on the basis that the scales were devised to improve discriminant validity of the subscales, which they have done, particularly if standard scores are used. Since four of the five factors are replicable in state and trait versions of the MAACL-R and clinical studies show discriminant validity for the subscales, there is no reason to ignore the components of the two broader affect factors. Such factors can be assessed through use of the two standard summary scores for the MAACL: Dysphoria (A + D + H) and Positive Affect plus Sensation Seeking (PA + SS).