复发转移性乳腺癌患者血浆VEGF水平的临床价值研究

探讨血浆血管内皮生长因子（P-VEGF）在乳腺癌术后复发转移患者中的表达情况及临床意义。采用酶联免疫吸附试验检测50例术后复发转移性乳腺癌患者及20例乳腺良性疾病对照组的P-VEGF含量,同期采用微粒子化学发光法检测术后复发转移性乳腺癌患者血清CEA和CA15-3的表达情况,进行对比研究。结论认为转移肿瘤细胞可产生大量...     

Psychological wellbeing of Turkish university students with physical impairments: an evaluation within the stress-vulnerability paradigm

Generally, universities in developing countries offer little in the way of provisions and support (material, emotional, etc.) for disabled students. Therefore, disabled students experience considerable burdens and barriers in their educational life. This study investigated the psychological wellbeing of disabled Turkish university students by examining influences on stress-related growth and psychological distress. Disability is defined within the framework of a social model. According to this view, impairment refers to the functional limitation(s) that affect(s) a person's body, whereas disability refers to the loss or limitation of opportunities owing to social, physical or psychological obstacles. Seventy disabled university students with physical impairments were administered a questionnaire package, including a sociodemographic information sheet, Ways of Coping Questionnaire, Stress-Related Growth Scale, Multidimensional Scale of Social Support, Life Events Inventory, and Brief Symptom Inventory. Snowball sampling was used and voluntary participation was essential. The results showed that disability burden, daily hassles, and helplessness coping were significant predictors of psychological symptoms. For stress-related growth the only variable that appeared significant was problem-solving coping. The results pointed out that there may be different pathways to distress and growth. In order to decrease psychological distress and enhance growth in disabled university students, disability awareness programs, changes in the barriers in the academic and physical environments of the university campuses, and coping skills training to increase problem-focused coping and to combat helplessness may prove to be effective. Reducing daily hassles for the disabled students is likely to contribute to their wellbeing by decreasing their burdens. Also, a more disability-friendly environment is likely to be empowering for disabled university students.     

时间贴现的分段性

以延迟和相对延迟时间贴现的实验范式, 用选择法、匹配法确定价值主观相等点, 探讨时间贴现的分段性。三个实验和一个问卷调查发现, 时间贴现具有分段性。被试的时间贴现有三次显著变化, 表现为三个时段时间贴现心理状态的不同: 从现在到未来2周内规避损失、偏好风险、愿意短期等待, 从未来2周起直到未来10年采取非补偿性策略、需求与风险并重、愿意长期等待, 和从未来10年起直到未来50年规避风险、聊胜于无、不愿意等待。     

垂直量尺化中的参数标定方法及其性能比较

在使用项目反应理论进行量尺化的语境下, 参数标定方法是垂直量尺化结果的一个至关重要的影响因素。目前的参数标定研究就部分标定方法的相对性能获得了较一致的结果, 就如何实现更佳量尺化也提出了很多新的标定方法。除了在既有框架内继续探索, 以形成完整的研究体系, 未来的研究应结合相关学科, 在深入了解学业增长的性质的基础上探究标定方法的性能, 并应考察特定的标定方法和特定的研究条件、量尺化语境之间的最佳匹配关系。     

Physical growth delays and stress dysregulation in stunted and non-stunted Ukrainian institution-reared children

To study the effect of institutional rearing on physical growth and stress regulation we examined 16 institution-reared children (3–6 years old) in Ukraine and compared them with 18 native family-reared children pair-matched on age and gender. Physical growth trajectories were examined on the basis of archival medical records and current measurements of height, weight, and head circumference. Stress regulation was studied on the basis of diurnal salivary cortisol sampled six times during 1 day. 31% of institution-reared children were stunted at 48 months whereas none of the family-reared children were. Substantial delays in physical growth were observed in institution-reared children especially during the first year of life. From 24 months onwards a tendency for improvement in physical growth was evident among the temporarily stunted institution-reared children, with complete catch-up in weight and partial catch-up in height by the time of assessment. Chronically stunted institution-reared children demonstrated persistent severe growth delays. Institution-reared and family-reared children showed similar patterns of diurnal cortisol production with decreases over the day. However, temporarily stunted institution-reared children had a significantly higher total daily cortisol production than both chronically stunted institution-reared children and family-reared children. These data confirm previous findings regarding physical growth delays and stress dysregulation associated with institutional care, but also point to differences in cortisol production between stunted and non-stunted institution-reared children.     

Interactive effects of work group and organizational identification on job satisfaction and extra-role behavior

Past research has focused on the differential relationships of organizational and work group identification with attitudes and behavior. However, no systematic effort has been undertaken yet to explore interactive effects between these foci of identification. We predicted that in cases of positive overlap of identifications (i.e. high work group and organizational identification) identifications are more strongly associated with employee job satisfaction and extra-role behavior than when only one of the identifications is high—that is, the one identification augments the influence of the other. These hypotheses were tested and supported with data from two samples of bank employees (N = 358) and travel agency employees (N = 308).     

Never quite good enough: The paradox of sticky developmental relationships for elite university graduates

Drawing on the mentoring, education, and social psychology literatures, this longitudinal study examines how the persistence of developmental relationships from an elite graduate school influences subjective career outcomes during early career. Participants (n = 136) were surveyed about their developmental networks—a group of individuals who take an active interest in and action to advance a focal individual’s career—and subjective career outcomes over the 10 years (1996-2006) post graduation. Results show that although receiving mentoring from one’s entire developmental network was positively related to career-related self-efficacy and perceptions of career success, this was not the case for ties retained from graduate school. Continuing to receive mentoring support from developers from graduate school and further, from peers from graduate school, was negatively related to perceptions of career success. These findings offer insight into the dynamics and potentially negative consequences of developmental networks and highlight the significance of social comparison during early career.     

白细胞介素-6和胎盘生长因子对子痫前期影响的研究

为探讨影响子痫前期患者发病的因素,对照性检测了子痫前期患者羊水中白细胞介素-6和胎盘中胎盘生长因子的变化。结果显示：子痫前期患者白细胞介素-6和胎盘生长因子均明显下降,且二者下降水平呈高度正相关。故联合检测白细胞介素-6和胎盘生长因子将对评估子痫前期的病情及指导临床决策具有重要意义。     

Genetics Education for Health Professionals: Strategies and Outcomes from a National Initiative in the United Kingdom

The National Health Service (NHS) National Genetics Education and Development Centre was established by the Department of Health in 2004 to help drive and co-ordinate genetics education for health professionals working outside specialist genetic services. This paper reviews the experiences and lessons learned to date. At the outset, it was clear that understanding the learning ethos, preferred delivery methods and attitudes towards genetics of different NHS healthcare groups was vital. We collected evidence by undertaking needs assessments with educators, practitioners and patients. We have determined the genetics knowledge, skills and attitudes which they said were needed and translated these into learning outcomes and workforce competences in a continuum of education. Beginning with core concepts introduced (and examined) pre-registration, the continuum continues with development of concepts post-registration as appropriate for role, leading to practical application and assessment of competences in the workplace. These are supported by a portfolio of resources which draw heavily on patient based scenarios to demonstrate to staff that genetics is relevant to their work, and to convince educators and policy makers that genetic education is likely to result in real clinical benefit. A long term educational policy, inclusive of learners, educationalists and their institutions must be evidence based, flexible and responsive to changes in workforce structure, provision of clinical services and conceptual and financial commitments to education. The engagement of national policy, regulatory and professional bodies is vital ().     

浅谈我国心理咨询师健康发展之要素

心理咨询与心理治疗效果的关键在于心理咨询与心理治疗师自身的特质,而非理论技巧。因此,心理咨询与心理治疗师在心理咨询与治疗的过程中,会非常直接、深刻和迅速地影响当事人的生活。通过对我国心理咨询师健康发展之要素的探讨,提出心理咨询师的培养应逐步走向正规专业教育和训练途径;同时关注心理咨询师自己的个人成长,健全督导制度是预防心理咨询师的职业耗竭,也是我国心理咨询业健康发展的根本保障。