Identification of emotional expressiveness in facial photographs over 36 h of extended vigilance in healthy young men—a preliminary study

Changes in sleep patterns negatively influence some emotional responses, but their effects on facial expressiveness identification are unclear. To investigate these effects, 21 young, healthy, male volunteers of intermediate chronotype evaluated emotional expressiveness of faces depicting 6 basic emotions in 5 emotional gradients every 4?h over 36?h of continuous wakefulness. To measure attention and mood we used the Psychomotor Vigilance test and the Positive and Negative Affect Schedule Expanded, respectively. We found effects of emotional gradient for all types of emotions (100%?>?80%?>?60%?>?40%?>?20%) during all tested periods, with no indications of circadian effects. The only emotional rating to be affected was disgust, which was progressively blunted throughout the experiment. This effect did not parallel homeostatic and circadian changes in mood, alertness or attention. We conclude that identifying disgust on facial photographs is particularly sensitive to lack of sleep irrespective of sleep-induced changes in mood and attention in males.     

融通以达变:论钱穆先生对《易传》的诠释

钱穆先生在<易传>的研究上,先从文献入手,发表<论十翼非孔子作>以厘清孔孟旧儒与战国时代新儒的不同;其后发表<易传与小戴礼记中之宇宙论>讲述代表战国新儒思想的<易传>,虽然与孔孟旧儒不同,但仅限于天体宇宙论的建构方面,盖因此领域为道家所擅.<易传>作者吸收道家之长,融通道家宇宙论,转而建立属于儒家的宇宙论,这是值得肯定的转变.正如钱先生文中一再致意的:<易传>虽吸收道家宇宙论的思想,但并未背弃儒家人生论的精髓,所以在吸收过程中皆予以转化,换句话说,便是将老庄自然宇宙观变成儒家德性的宇宙观,以求合于传统儒家的人生哲学.     

Endogenous opioid peptides contribute to associative LTP in the hippocampal CA3 region

The medial and lateral perforant path projections to the hippocampal CA3 region display distinct mechanisms of long-term potentiation (LTP) induction, N-methyl-d-aspartate (NMDA) and opioid receptor dependent, respectively. However, medial and lateral perforant path projections to the CA3 region display associative LTP with coactivation, suggesting that while they differ in receptors involved in LTP induction they may share common downstream mechanisms of LTP induction. Here we address this interaction of LTP induction mechanisms by evaluating the contribution of opioid receptors to the induction of associative LTP among the medial and lateral perforant path projections to the CA3 region in vivo. Local application of the opioid receptor antagonists naloxone or Cys2-Tyr3-Orn5-Pen7-amide (CTOP) normally block induction of lateral perforant path-CA3 LTP. However, these opioid receptor antagonists failed to block associative LTP in lateral perforant path-CA3 synapses when it was induced by strong coactivation of the medial perforant pathway which displays NMDAR-dependent LTP. Thus strong activation of non-opioidergic afferents can substitute for the opioid receptor activation required for lateral perforant path LTP induction. Conversely, medial perforant path-CA3 associative LTP was blocked by opioid receptor antagonists when induced by strong coactivation of the opioidergic lateral perforant path. These data indicate endogenous opioid peptides contribute to associative LTP at coactive synapses when induced by strong coactivation of an opioidergic afferent system. These data further suggest that associative LTP induction is regulated by the receptor mechanisms of the strongly stimulated pathway. Thus, while medial and lateral perforant path synapses differ in their mechanisms of LTP induction, associative LTP at these synapses share common downstream mechanisms of induction.     

“时间窗”—— 认知加工的后勤基础

时间加工是认知加工的内在属性。因此, 理解发生在知觉或更广泛的认知过程中的时间加工极为重要。为了应对中枢信息加工所面临的外部挑战, 大脑显然已形成了一些用于整合信息的特殊时间窗。已经发现, 其中一个时间窗介于数十毫秒的范围内, 它用于为意识活动产生必要的建构单元。来自反应时、时序阈限以及神经元结构振荡反应的研究为该时间窗的存在提供了实证证据。另一个时间窗的作用范围是2~3秒, 它用于产生“主观现在感”或作为使知觉体的标识保持不变的时间整合区间。支持该窗口存在的实验证据来自时距再现、两可图形、感觉运动同步以及神经生理学研究。还有一种时间窗以昼夜节律的形式存在。所有的心理和生理功能似乎都有着24小时的周期性变化。时间窗的紊乱会以神经或精神疾病的形式表现出来, 这恰恰表明了在基础研究之外对时间加工进行研究的重要性。     

环境光照的认知功效及其调节因素与作用机理

自人类视网膜上发现存在新型的内在光敏感神经节细胞以来, 环境光照对个体生理心理功能的非视觉作用备受研究者青睐, 其中环境光照对认知功能的非视觉作用结果并不十分一致且内在机理尚不明确。环境光照的认知功效会受到光学参数、光照模式、时间因素、个体差异以及任务特征等的共同调节。未来的研究需要从环境光对心理认知功能的作用模式, 动态办公照明系统的开发, 面向特殊群体的个性化照明以及光照非视觉作用产生的分子生物学机制等视角进行扩展和深化。     

Fractal dynamics of heart beat interval fluctuations in corticotropin-releasing factor receptor subtype 2 deficient mice

Non-linear fractal analysis of cardiac interbeat time series was performed in corticotropin-releasing factor receptor subtype 2 (CRFR2) deficient mice. Heart rate dynamics in mice constitutes a self-similar, scale-invariant, random fractal process with persistent intrinsic long-range correlations and inverse power-law properties. We hypothesized that the sustained tachycardic response elicited by intraperitoneal (ip) injection of human/rat CRF (h/rCRF) is mediated by CRFR2. In wildtype control animals, heart rate was increased to about maximum levels (~ 750 bpm) while in CRFR2-deficient animals baseline values were retained (~ 580 bpm). The tachycardic response elicited by ip-application is mediated by CRFR2 and is interpreted to result from sympathetic stimulation. However, the functional integrity of CRFR2 would not present a prerequisite to maintaining the responsiveness and resiliency of cardiac control to external environmental perturbations experimentally induced by extrinsic ip-application of h/rCRF or under physiological conditions that may be associated with an increased peripheral release of CRF. Under stressful physiological conditions achieved by novelty exposure, CRFR2 is not involved in the cardiodynamic regulation to external short-term stress. While the hypothesis of involvement of CRFR2 in cardiac regulation upon pharmacological stimulation cannot be rejected, the present findings suggest that the mechanism of action is by sympathetic stimulation, but would not unambiguously allow to draw any conclusions as to the physiological role of CRFR2 in the control of cardiac dynamics.     

Differential short-term memorisation for vocal and instrumental rhythms

This study explores differential processing of vocal and instrumental rhythms in short-term memory with three decision (same/different judgments) and one reproduction experiment. In the first experiment, memory performance declined for delayed versus immediate recall, with accuracy for the two rhythms being affected differently: Musicians performed better than non-musicians on clapstick but not on vocal rhythms, and musicians were better on vocal rhythms in the same than in the different condition. Results for the second experiment showed that concurrent sub-vocal articulation and finger-tapping differentially affected the two rhythms and same/different decisions, but produced no evidence for articulatory loop involvement in delayed decision tasks. In a third experiment, which tested rhythm reproduction, concurrent sub-vocal articulation decreased memory performance, with a stronger deleterious effect on the reproduction of vocal than of clapstick rhythms. This suggests that the articulatory loop may only be involved in delayed reproduction not in decision tasks. The fourth experiment tested whether differences between filled and empty rhythms (continuous vs. discontinuous sounds) can explain the different memorisation of vocal and clapstick rhythms. Though significant differences were found for empty and filled instrumental rhythms, the differences between vocal and clapstick can only be explained by considering additional voice specific features.     

血压的生物节律与高血压的时间治疗学

人体血压的昼夜节律现象具有重要临床意义,高血压病更尤为如此。不同降压药物或不同时间用药对血压的昼夜节律产生不同的影响。高血压时间治疗学是根据疾病发生或发作的昼夜节律特征,通过调整投药时间及/或剂量、或应用特殊制剂,调整血液或组织中的药物浓度,从而增加疗效并减少或避免不良反应的发生。时间治疗学方法有助于以最小的医疗经济学及毒副反应代价获取最佳的治疗效果。     

Time-space learning in homing pigeons (<Emphasis Type="Italic">Columba livia</Emphasis>): orientation to an artificial light source

Time-space learning reflects an ability to represent in memory event-stimulus properties together with the place and time of the event; a capacity well developed in birds. Homing pigeons were trained in an indoor octagonal arena to locate one food goal in the morning and a different food goal in the late afternoon. The goals differed with respect to their angular/directional relationship to an artificial light source located outside the arena. Further, the angular difference in reward position approximated the displacement of the sun's azimuth that would occur during the same time period. The experimental birds quickly learned the task, demonstrating the apparent ease with which birds can adopt an artificial light source to discriminate among alternative spatial responses at different times of the day. However, a novel midday probe session following successful learning revealed that the light source was interpreted as a stable landmark and not as a surrogate sun that would support compass orientation. Probe sessions following a phase shift of the light–dark cycle revealed that the mechanism employed to make the temporal discrimination was prevailingly based on an endogenous circadian rhythm and not an interval timing mechanism.