Developmental Instability and Individual Variation in Brain Development: Implications for the Origin of Neurodevelopmental Disorders

ABSTRACT— Research on the origin of neurodevelopmental disorders has traditionally been pursued within a constrained, disorder-specific perspective. The developmental instability (DI) model described here offers a broader approach based on the evolutionary genetics of normal variation, reflecting our understanding that the processes generating genetic diversity are not unique to any specific disorder. The DI model helps account for shared features, including atypical functional and anatomic asymmetries, reduced general intellectual functioning, and complex patterns of heritability, across different types of neural variation. The model suggests research strategies that may help illuminate the specific and unique causal factors characterizing different types of neural variation.     

对老年认知障碍中医药防治研究的思考和对策

中医学基础理论和临床实践范式的特殊性,使得中医学科学研究面临着困惑和困难。本文从“中医理法”的角度对中医药防治老年认知障碍研究工作进行了思考,提出应重视辨病论治和辨证论治相结合;重视预防研究;重视病因研究;重视体质研究;强调形神合一;跟踪现代医学研究的进展;重视科研方法学和技术的学习和应用,以进一步提高中医科学研究工作的水平。     

协作还是斗争——心理障碍治疗百年

长期以来,在心理障碍治疗领域存在着心理治疗师与精神科医生的相互斗争,从协作的角度对心理治疗百年史进行回顾,认为百年心理治疗史实际上是心理医生与临床医生相互斗争走向协作的历史。这一过程可大致区分为自发、附属、斗争到整合四大阶段。就长远来看,在心理障碍的治疗中,这两类专业人员的相互配合是不可避免的。     

Correlates of Depressive Disorders in the Quebec General Population 6 to 14 Years of Age

There are relatively few community-based epidemiological studies in which correlates of depressive disorders were identified through multivariate analyses in children and adolescents aged 6--14 years. Moreover, several family characteristics (e.g., parent-child relationship) have never been explored in this regard. The purpose of this study was twofold. Using data from the Quebec Child Mental Health Survey, it sought: (1) to identify psychosocial correlates associated with depressive disorder in two age-groups (6--11 and 12-14 years) according to informant (child/adolescent, parent); and (2) to interpret the relative importance of correlates by ranking variables according to strength and consistency of association across age-groups. Logistic regression models show correlates to be inconsistent across informants. The ranking of correlates indicates a major contribution of only-child status/ordinal position, parent's major depressive disorder, stressful family events, and parent-child relationship, thereby supporting the hypothesis of the relevance of family context in the development of depression.     

What ends a worry bout? An analysis of changes in mood and stop rule use across the catastrophising interview task

This paper reports the results of two experiments designed to test predictions from the mood-as-input hypothesis about the factors that contribute to the ending of a worry bout. Experiment 1 looked at changes in self-reported mood across a catastrophising interview task. Experiment 2 investigated whether there were any changes in stop rule deployment between the beginning and end of a catastrophising interview task. Experiment 1 demonstrated that worriers tended to show increases in negative mood and decreases in positive mood over the course of catastrophising. In Experiment 2, participants exhibited a significant shift away from endorsing the use of 'as many as can' stop rules and a significant increasing tendency to endorse the use of 'feel like continuing' stop rules over the course of catastrophising. These results suggest that worriers exhibit increases in negative mood across the worry bout, but shift from the use of 'as many as can' to 'feel like continuing' stop rules. Mood-as-input hypothesis predicts that if high worriers ask the question "do I feel like continuing?" in the context of increasing negative mood, this will imply that the activity is no longer enjoyable or profitable and should be terminated. The results are discussed in the context of mood-as-input accounts of pathological worrying and the therapeutic implications of these findings are reviewed.     

Quantity versus uncertainty: When winning one prize is better than winning two

We predicted that a state of uncertainty would prolong a positive mood, but that people would not anticipate this when making affective forecasts. In Study 1, participants learned that they had won one prize (certain condition), two prizes (two-gift condition), or one of two prizes (uncertain condition). People in the uncertain condition were in a positive mood longer than people in the other two conditions. In Study 2, forecaster participants underestimated the benefits of uncertainty and overestimated the benefits of quantity (getting two gifts instead of one). Under some circumstances, and contrary to people’s predictions, uncertainty can prolong positive mood, and winning one prize under a state of uncertainty can bring more short-term pleasure than winning two prizes.     

An experimental analysis of body checking

The relationship between repeated body checking and its impact on body size estimation and body dissatisfaction is of interest for two reasons. First, it has importance in theoretical accounts of the maintenance of eating disorders and, second, body checking is targeted in cognitive-behavioural treatment. The aim of this study was to determine the impact of manipulating body checking on body size estimation and body dissatisfaction. Sixty women were randomly assigned either to repeatedly scrutinize their bodies in a critical way in the mirror ("high body checking") or to refrain from body checking but to examine the whole of their bodies in a neutral way ("low body checking"). Body dissatisfaction, feelings of fatness and the strength of a particular self-critical thought increased immediately after the manipulation among those in the high body checking condition. Feelings of fatness decreased among those in the low body checking condition. These changes were short-lived. The manipulation did not effect estimations of body size or the discrepancy between estimations of body size and desired body size. The implications of these findings for understanding the influence of body checking on the maintenance of body dissatisfaction are considered.     

The effects of analytical and experiential rumination on autobiographical memory specificity in individuals with a history of major depression

This study examined the relationship between analytical rumination and autobiographical memory specificity in participants with a history of depression. Participants completed the autobiographical memory test twice, once before and once after an 8 min manipulation designed to increase either an abstract/analytical or concrete/experiential mode of information processing. Results indicated a significant three-way time (pre, post)×manipulation (analytical, experiential)×depressive rumination (high, low) interaction. This interaction was the result of a significant decline in memory specificity from pre- to post-manipulation in individuals reporting high levels of rumination about symptoms when depressed who were allocated to the analytical condition. The findings of this study extend previous work, suggesting that low memory specificity in formerly depressed patients may be a function of state levels of analytical self-focus, with this cognitive style being more easily reinstated in the recovery phase in those who report a greater trait tendency to ruminate about symptoms when low in mood.     

The influence of induced mood on the inhibition of emotional information

The ability to inhibit affective information plays a major role in efficient cognitive processing. In this study the effect of mood induction on inhibitory processing of emotional material was investigated. In Experiment 1, performance on a negative affective priming task (NAP) following negative and positive mood induction (MIP) was compared to a neutral mood condition. Results revealed that, as compared with the neutral mood condition, inhibitory function for affective material was unaffected by negative MIP. However, after the positive MIP, inhibitory processes were significantly impaired. In Experiment 2, we replicated and extended the findings on positive affect and inhibition. The data concerning positive mood fit with the general findings that positive mood often leads to a “loose, flexible” processing mode. The null-finding concerning negative mood and inhibition is discussed in the light of research on inhibition in depression.     

Ethnic differences in BMI, weight concerns, and eating behaviors: comparison of Native American, White, and Hispanic adolescents

Evidence suggests that substantial proportions of adolescents, regardless of ethnicity or gender, are engaged in excessive weight control behaviors. Crago and Shisslak (2003), however, have noted that small samples and poorly validated instruments have limited the value of previous ethnic difference studies. Using the McKnight Risk Factor Survey, we compared Native American, White, and Hispanic adolescents. Native students were divided into groups with one (NA-mixed) or two (NA) Native American biological parents. Surveys were completed by 5th through 10th grade students. BMI z-scores were significantly higher for boys and girls in the NA group, and boys in this group were significantly more engaged in weight control behaviors, including purging. A higher percentage of Native and Hispanic girls preferred a larger body size. BMI was positively correlated with weight and shape concerns and with weight control behaviors, regardless of ethnicity or gender. Overweight among Native adolescents may put them at greater risk for eating problems than their White peers.