糖尿病高血压和糖尿病肾病患者血清MMP-2及TIMP-1的表达及意义

为了探讨MMP-2、TIMP-1在DMEH和DN发病中的意义,随机收集T2DM患者146例,其中SDM 57例,DMEH 38例,DN 51例,健康对照38例。用ELISA法测定MMP-2、TIMP-1的含量。结果显示,DM患者尤其是DMEH和DN患者血清MMP-2明显低于健康对照组,P均〈0.01,且随病情发展呈逐渐降低趋势。而血清TIMP-1随病情的发展则呈现明显的上升趋势,SDM、DMEH组和DN组与健康对照组比较,分别为P〈0.05,P〈0.01和P〈0.01。因此,MMP-2和TIMP-1可能参与了DMEH和DN的发生发展过程,定期检测DM患者血清MMP-2和TIMP-1的含量变化有助于DM并发症的早期诊断和疗效观察。     

公正:对待同性恋者的主要伦理原则

同性恋问题由来已久,但至今同性恋者仍处于社会的边缘和弱势地位,提出旨在对这一问题的解决提出公正原则是对待同性恋者的主要伦理原则.通过践行伦理公正,使其获得应有的权利,从而使同性恋者获得合理的地位,实现其做人的价值.     

Learning of letter names and sounds and their contribution to word recognition

This study investigated knowledge of letter names and letter sounds, their learning, and their contributions to word recognition. Of 123 preschoolers examined on letter knowledge, 65 underwent training on both letter names and letter sounds in a counterbalanced order. Prior to training, children were more advanced in associating letters with their names than with their sounds and could provide the sound of a letter only if they could name it. However, children learned more easily to associate letters with sounds than with names. Training just on names improved performance on sounds, but the sounds produced were extended (CV) rather than phonemic. Learning sounds facilitated later learning of the same letters' names, but not vice versa. Training either on names or on sounds improved word recognition and explanation of printed words. Results are discussed with reference to cognitive and societal factors affecting letter knowledge acquisition, features of the Hebrew alphabet and orthography, and educational implications.     

Everything is What it is,and Not Another Thing: Knowledge and Freedom in Isaiah Berlin's Political Thought

Although Isaiah Berlin's critique of positive liberty has achieved canonical status, its place within his wider political philosophy remains obscure. However, the re-publication of one of his most important philosophical essays, From Hope and Fear Set Free, as part of a new edition of Four Essays on Liberty, simply entitled Liberty, has opened the door to a re-evaluation of Berlin's political project.

At the heart of Berlin's argument, which gains its fullest expression in From Hope and Fear Set Free, stands his contention that positive liberty, in its incarnation as self-realisation, conflates liberty with knowledge, which leads to the distortion of our phenomenologically inescapable structure of experience. This transgression against the conceptual framework in terms of which we think, Berlin argues, played its desolate part in linking the ‘totalitarian temptation’ latent in liberty as self-realisation with the totalitarian politics of the mid-twentieth century.     

2型糖尿病大血管病变机理和糖尿病治疗

2型糖尿病大血管病变与代谢综合征密切相关.现代医学认为两者的根本原因是胰岛素抵抗,导致糖耐量下降,血脂紊乱,高胰岛素血症,高血压和高凝状态等.从系统论的观点阐述了代谢综合征的相互关系和2型糖尿病大血管病变发病机理,并进一步从该观点阐明2型糖尿病的防治策略.     

A Dissociation between Symbolic Number Knowledge and Analogue Magnitude Information

Semantic understanding of numbers and related concepts can be dissociated from rote knowledge of arithmetic facts. However, distinctions among different kinds of semantic representations related to numbers have not been fully explored. Working with numbers and arithmetic requires representing semantic information that is both analogue (e.g., the approximate magnitude of a number) and symbolic (e.g., what / means). In this article, the authors describe a patient (MC) who exhibits a dissociation between tasks that require symbolic number knowledge (e.g., knowledge of arithmetic symbols including numbers, knowledge of concepts related to numbers such as rounding) and tasks that require an analogue magnitude representation (e.g., comparing size or frequency). MC is impaired on a variety of tasks that require symbolic number knowledge, but her ability to represent and process analogue magnitude information is intact. Her deficit in symbolic number knowledge extends to a variety of concepts related to numbers (e.g., decimal points, Roman numerals, what a quartet is) but not to any other semantic categories that we have tested. These findings suggest that symbolic number knowledge is a functionally independent component of the number processing system, that it is category specific, and that it is anatomically and functionally distinct from magnitude representations.     

Knowledge and economic growth—creativity,learning and knowledge utilization

The purpose of this study is to discuss the dynamic interdependence of knowledge and economic growth. We show that the traditional economics, which treats knowledge as parameters and is mainly developed within linearized, stable and static frameworks can hardly explain the modern economic complexity. We argue that it is necessary to treat creativity, learning and knowledge utilization as endogenous dynamic processes of social and economic evolution. To handle with the complicated dynamic interdependence of wealth and knowledge accumulation, we need to apply genuine nonlinear dynamic theory. In particular, we discuss possible benefits of government's intervention in education and science to the society when the social and economic evolution is characterized of nonlinearity, instability and multi‐equilibria.     

Test anxiety and comprehension efficiency: The role of prior knowledge and working memory deficits

The hypotheses that test anxiety is associated with a deficit in prior knowledge and/or working memory capacity, that anxiety impairs comprehension efficiency, and that deficits in knowledge and capacity underlie the efficiency impairment, were tested. In Study 1, high-anxiety students were characterized by lower scores in several vocabulary measures, compared with low-anxiety students. In Study 2, high-anxiety individuals showed inferior working memory capacity to low-anxiety individuals under evaluative stress conditions, but not under non-stress conditions. In Study 3 high-anxiety subjects exhibited lower efficiency scores than low-anxiety subjects in expository texts without a summary: The former employed a greater amount of reading time than the latter to acquire an equivalent amount of information. In addition, the disadvantage in efficiency associated with anxiety was removed when differences in vocabulary knowledge were partialled out statistically. Instead, that disadvantage was only reduced, but not eliminated, when differences in transitory working memory capacity were partialled out. Therefore, the prior knowledge deficit hypothesis accounts for the impairment in reading efficiency associated with high anxiety better than the transitory working memory reduction hypothesis.     

一致的先前知识对类别学习影响机制探讨

探讨一致的先前知识对类别学习的影响,包括2个实验。被试是112名大学生,分别探讨不同实验任务和不同项目呈现时间引发的机械特征在类别学习中的重要程度和加工程度不同的情况下先前知识对类别学习的影响。结果表明:(1)在实验任务为项目类别归属判断任务时,机械特征重要程度低,主题特征与机械特征在学习上存在竞争关系;在实验任务为项目类别归属及记忆任务时,机械特征重要程度高,主题特征与机械特征在学习上存在促进关系。(2)在限制步速呈现项目时,机械特征加工程度低,主题特征与机械特征在学习上存在竞争关系;而在自定步速呈现项目时,机械特征加工程度高,主题特征与机械特征在学习上不存在竞争关系。     

The accidental transgressor: morally-relevant theory of mind

To test young children’s false belief theory of mind in a morally relevant context, two experiments were conducted. In Experiment 1, children (N = 162) at 3.5, 5.5, and 7.5 years of age were administered three tasks: prototypic moral transgression task, false belief theory of mind task (ToM), and an “accidental transgressor” task, which measured a morally-relevant false belief theory of mind (MoToM). Children who did not pass false belief ToM were more likely to attribute negative intentions to an accidental transgressor than children who passed false belief ToM, and to use moral reasons when blaming the accidental transgressor. In Experiment 2, children (N = 46) who did not pass false belief ToM viewed it as more acceptable to punish the accidental transgressor than did participants who passed false belief ToM. Findings are discussed in light of research on the emergence of moral judgment and theory of mind.