从不规范联合用药转变为单药治疗过程分析抗癫痫药物的选择策略

单药治疗或合理的联合用药是癫痫治疗的重要原则,本文运用抗癫痫药物的药代动力学知识,分析了1例复杂不规范的联合用药导致治疗失败的原因,系统讲解了将其转变为有效的传统或新型抗癫痫药物单药治疗的理论和实践过程,并以此展示抗癫痫药物的选择策略。     

儿童缺血性脑病的诊治策略

结合国内外文献资料,从儿童缺血性脑病的病因、临床表现、影像学特点、治疗方式及疗效等方面着手,进行分析和比较,加深医患对儿童缺血性脑病的了解,同时为该类疾病的临床诊断与治疗思路提供借鉴。     

克服肿瘤干细胞耐药性的策略和思路

肿瘤干细胞（cancersterncells,CSCs）是肿瘤细胞的祖细胞。已有的研究表明,肿瘤干细胞对多种化疗药物具有耐药性,是导致肿瘤治疗后复发的根源。研究针对肿瘤干细胞的治疗方法,克服肿瘤干细胞耐药性,将给肿瘤治疗模式带来全新的改变,有望彻底改善肿瘤患者的预后。     

《乾》卦爻辞与周文王克商方略

《乾》卦爻辞的思想与周文王克商的整体战略有许多契合之处,如:“潜龙勿用”,与文王根据实力采取战略守势;“见龙在田”,与文王对西土方国的团结怀柔;“夕惕若厉”,与文王小心翼翼地臣事段商王朝;“或跃在渊”,与文王对大邑商发动战略进攻;“飞龙在天”,与文王谋划灭商的战略决战;“亢龙有悔”,与文王认识到攻取之道不可久用;“群龙无首”,与文王设计从武功向文治的战略转移等,皆有相通相合的地方.《乾》卦爻辞与文王克商方略之间的诸多契合表明,殷周之际王朝更迭的沧桑巨变,深刻地影响了《乾》卦爻辞的撰作.其中,文王克商的方略及其过程,应是《乾》卦最为重要的思想渊源之一.     

内隐学习策略的存在及其外显转化

该研究采用＂乘法算式答案正误判断的实验室任务＂,以＂奇偶检查策略＂为具体策略研究对象,探查内隐奇偶检查策略的存在及其自动性特征。实验结果表明：（1）奇偶检查策略可以以内隐方式存在,但经过不断练习可最终上升到意识层面;（2）奇偶检查策略的外显和内隐使用表现出各自独立的优势效应。外显学习策略的优势效应主要表现在正确算式判断任务中,而内隐学习策略则在错误算式判断任务中表现出＂内隐优势效应＂的趋势;（3）内隐奇偶检查策略的人为外显化并不能促使个体增加使用该策略的频率,也不能有效提高策略的执行效率。     

Weighting of contingency information in causal judgement: Evidence of hypothesis dependence and use of a positive-test strategy

Contingency is an important cue to causation. Research shows that people unequally weight the cells of a 2 × 2 contingency table as follows: cause-present/effect-present (A) > cause-present/effect-absent (B) > cause-absent/effect-present (C) > cause-absent/effect-absent (D). Although some models of causal judgement can accommodate that fact, most of them assume that the weighting of information is invariant as a function of whether one is assessing a hypothesized generative versus preventive relationship. An experiment was conducted that tested the hypothesis-independence assumption against the predictions of a novel weighted-positive-test-strategy account, which predicts hypothesis dependence in cell weighting. Supporting that account, judgements of hypothesized generative causes showed the standard A > B > C > D inequality, but judgements of hypothesized preventive causes showed the predicted B > A > D > C inequality. The findings reveal that cell weighting in causal judgement is both unequal and hypothesis dependent.     

Using mnemonic images and explicit sound contrasting to help Japanese children learn English alphabet sounds

Although mnemonics have been shown to be effective in remembering letter-sound associations, the use of foreign words as cues for English phonemes had not been investigated. Learning phonemes in Japan is challenging because the Japanese language is based on a different sound unit called mora (mostly consonant-vowel combinations). This study investigated the effectiveness of using mnemonic images utilizing Japanese words as cues for the phonemes, and explicit sound contrasting of phonemic sounds with morae they could be confused with, in facilitating children's acquisition of knowledge about alphabet letter-sound correspondence. The participants were 140 6th-grade Japanese students who were taught phoneme-consonant correspondence, with or without the use of mnemonics or explicit sound contrasting. Analysis of the students’ pre- and post-instruction assessments revealed significant interaction effects between types of instruction provided and instruction phase, indicating better performance in letter-sound association as a consequence of the inclusion of both mnemonics and explicit sound contrasting.     

Maintenance strategy selection with risky evaluations using RAHP

In recent years, maintenance, especially its preventive type, has been seen as an effective and considerable factor in improving the functions of machines. Maintenance plays a vital role in organizations by keeping and increasing the reliability, accessibility, the quality of products, risk mitigation, return improvement, and safety. An effective maintenance programme can be realized by implementing a proper maintenance strategy. Therefore, maintenance and its strategies have a special status in industries. However, selecting a proper maintenance strategy has always been a complex process because maintenance is a nonrepetitive task. Likewise, the lack of failure records and constant changes in the conditions of machines makes it further complicated. Hence, the decision‐making also depends on experts' opinions and because some kind of risk and uncertainty are always there in experts evaluations, the reliability of evaluations is questionable. The present study was aimed to develop a risk‐based model grounded on the analytical hierarchical process, namely, RAHP, to meet this need of maintenance. A case study from a steel rolling company was considered to evaluate the effectiveness of this model.     

The use of coping strategies by Danish children classed as bullies, victims, bully/victims, and not involved, in response to different (hypothetical) types of bullying

The coping strategies employed in response to different types of bullying, by 305 Danish children (142 boys, 163 girls) in school years four to nine (aged 10-15 years), were investigated. Children were classed into four bully-victim status types. A revised version of the Olweus Bully/Victim Questionnaire was used for the classification of children, and a Self-Report Coping Measure for the investigation of coping strategies. The coping strategy of Externalizing was used significantly more by children classed as bully/victims compared with victims and not involved children: Seeking Social Support and Internalizing were preferred significantly more by girls, whereas Externalizing was preferred significantly more by boys; Distancing, Seeking Social Support, and Internalizing were favored significantly more by children in years four to six compared with children in years seven to nine. Looking at coping strategies in response to different types of bullying, Seeking Social Support was used significantly more in response to attack on property relative to verbal bullying, social exclusion, and indirect bullying, and Distancing was used significantly less in response to attack on property compared with any of the other types of bullying. The results are discussed in relation to implications for educational practice.     

Chunking versus foraging search patterns by rats in the hierarchically baited radial maze

Rats were exposed to a radial maze containing six black smooth arms and six wire-grid-covered arms and a striped 'exit arm' in experiment 1. The probability of a black or grid arm being baited (5/6 vs 1/6) with sunflower seeds was associated with its proximal cue for some rats (the Relevant Arm Cue group) but not for others (the Irrelevant Arm Cue group). All rats could terminate a trial and receive a highly preferred morsel of apple by entering the exit arm only after having sampled all six seed-baited arms. Relevant Arm Cue rats usually chose some arms from the more densely baited set before choosing an arm from the less densely baited set and made fewer reentries than Irrelevant Arm Cue rats. Although such clustered, higher choice accuracy in the Relevant Arm Cue group corresponds to human clustered, better recall of verbal items from lists hierarchically organized by categories, these rats did not similarly exhaustively retrieve items (arm locations). That is, when required to terminate a trial by entering the 'exit' arm for an apple morsel after having sampled all seed-baited arms, both groups were equally unable to withhold making nonrewarded premature exits. This nonexhaustive foraging search pattern was maintained in the next two experiments in which the radial maze was reduced to three black and three grid arms along with the striped 'exit' arm and in which black and grid arm cues were paired with number of seeds (eight or one) in an arm for Relevant Arm Cue rats. Although Relevant Arm Cue rats displayed perfect clustering by entering all eight-seeded arms before a one-seeded arm, they made more premature exits and reentries into eight-seeded arms in experiment 2 or when forced to enter all eight-seeded arms in experiment 3 than did Irrelevant Arm Cue rats. These foraging tendencies prevent accurate estimations of the amount of information (i.e., arm locations) rats can 'chunk'. Electronic Publication