变形汉字的结构方式和笔画数效应

曾捷英等提出并采用了汉字通透性概念解释汉字识别中的字形属性效应,例如笔画数效应、笔画类型效应和结构方式效应。在有关研究中采用的主要实验方法是在速示、重复速示、非速示、时间或空间微观发生等条件下要求被试命名汉字。该研究将采用新的实验方法,即在呈现变形汉字1200ms后要求被试报告识别内容。结构方式和笔画数两种字形属性为研究对象。实验结果表明存在着常规的结构方式效应和笔画数效应,尤为重要的是观察到了逆转的结构方式效应。客观计算出的汉字通透性可以合理地解释这些效应。该研究和先前研究部分证明了关于汉字字形知觉的一个重要假设：汉字通透性是形成各种字形属性效应的基本或主导原因。字形属性对汉字识别的影响可以归结为通透性的影响,这称之为通透性中介假设。     

中风病简化辨证的哲学思考

中风病分阴证和阳证为纲辨治,不但有是充分的实践依据和理论基础,而且符合哲学的否定之否定定律。从中风病简化辨证的必要性,中风病阴阳辨证的发展,中风病的病因病机、证候属性可从阴阳两方面认识,中风病阴阳为纲辨证方法符合哲学否定之否定定律4方面进行了论述。     

我国脑卒中的经济负担及影响因素分析——临床决策要关注病人的经济负担

通过综合近10年来的脑卒中经济负担的相关文献,主要描述了我国脑卒中的直接经济负担和间接经济负担,并对其经济负担的影响因素作了分析,提出了减轻脑卒中的经济负担的有效途径,表明关注病人的经济负担是临床决策的重要课题。     

中医卒中单元之系统分析

卒中单元是目前最有效的卒中治疗方法。在卒中单元基础上,加入中医防治中风的理论和方法,构建中医卒中单元,具备坚实的的理论基础和深厚的临床积淀。中医卒中单元是中国引进、发展和完善卒中单元,符合中国国情的必然产物,具有强大的生命力。按“优化人力资源、发挥中医优势,实现卒中疗效最大化”原则,对中医卒中小组进行重组、优化。按中医与西医结合、急救与康复结合、针灸与药物结合、循证医疗与个体化医疗结合、饮食与心理调护结合、治疗与预防结合等原则,优化治疗方案。开展中医药及针灸治疗卒中的多中心随机对照研究,建立中医药治疗卒中资料库,可为中医卒中单元提供强有力循证医学证据。     

进展性脑梗死的形成机制与防治策略

进展性脑梗死是临床上常见的一种缺血性脑卒中,其发病率高,致残率高,预后较差,严重危害患者的生命和健康,成为临床卒中治疗的一大难题。本文结合近年来的有关研究文献,就进展性脑梗死的临床分型、形成机制、可能的危险因素及其防治策略等方面的研究进展作一综合性介绍。     

The Use of the Term Virtual Reality in Post-Stroke Rehabilitation: A Scoping Review and Commentary

Virtual reality (VR) offers many opportunities for post-stroke rehabilitation. However, “VR” can refer to several types of computer-based rehabilitation systems. Since these systems may impact the feasibility and the efficacy of VR interventions, consistent terminology is important. In this study, we aimed to optimize the terminology for VR-based post-stroke rehabilitation by assessing whether and how review papers on this topic defined VR and what types of mixed reality systems were discussed. In addition, this review can inspire the use of consistent terminology for other researchers working with VR. We assessed the use of the term VR in review papers on post-stroke rehabilitation extracted from Scopus, Web of Science and PubMed. We also developed a taxonomy distinguishing 16 mixed reality systems based on three factors: immersive versus semi-immersive displays, the way in which real and virtual information is mixed, and the main input device. 64% of the included review papers (N = 121) explicitly defined VR and 33% of them described different subtypes of VR, with immersive and non-immersive VR as the most common distinction. The most frequently discussed input devices were motion-capture cameras and handheld devices, while regular 2D monitors were the most frequently mentioned output devices. Our analysis revealed that reviews on post-stroke VR rehabilitation did not or only broadly defined “VR” and did not focus on a specific system. Since the efficacy and feasibility of rehabilitation may depend on the specific system, we propose a new data-driven taxonomy to distinguish different systems, which is expected to facilitate communication amongst researchers and clinicians working with virtual reality.     

Spatial navigation deficits in amnestic mild cognitive impairment with neuropsychiatric comorbidity

Aims: To find out whether neuropsychiatric comorbidity (comMCI) influences spatial navigation performance in amnestic mild cognitive impairment (aMCI).

Methods: We recruited aMCI patients with (n = 21) and without (n = 21) neuropsychiatric comorbidity or alcohol abuse, matched for global cognitive impairment and cognitively healthy elderly participants (HE, n = 22). They completed the Mini-Mental State Examination and a virtual Hidden Goal Task in egocentric, allocentric, and delayed recall subtests.

Results: In allocentric navigation, aMCI and comMCI performed significantly worse than HE and similarly to each other. Although aMCI performed significantly worse at egocentric navigation than HE, they performed significantly better than patients with comMCI.

Conclusions: Despite the growing burden of dementia and the prevalence of neuropsychiatric symptoms in the elderly population, comMCI remains under-studied. Since trials often assess “pure” aMCI, we may underestimate patients’ navigation and other deficits. This finding emphasizes the importance of taking account of the cognitive effects of psychiatric disorders in aMCI.     

Investigating virtual reality navigation in amnestic mild cognitive impairment using fMRI

Spatial navigation requires a well-established network of brain regions, including the hippocampus, caudate nucleus, and retrosplenial cortex. Amnestic Mild Cognitive Impairment (aMCI) is a condition with predominantly memory impairment, conferring a high predictive risk factor for dementia. aMCI is associated with hippocampal atrophy and subtle deficits in spatial navigation. We present the first use of a functional Magnetic Resonance Imaging (fMRI) navigation task in aMCI, using a virtual reality analog of the Radial Arm Maze. Compared with controls, aMCI patients showed reduced activity in the hippocampus bilaterally, retrosplenial cortex, and left dorsolateral prefrontal cortex. Reduced activation in key areas for successful navigation, as well as additional regions, was found alongside relatively normal task performance. Results also revealed increased activity in the right dorsolateral prefrontal cortex in aMCI patients, which may reflect compensation for reduced activations elsewhere. These data support suggestions that fMRI spatial navigation tasks may be useful for staging of progression in MCI.     

Using fMRI to study recovery from acquired dysphasia

We have used functional magnetic resonance imaging (fMRI) to characterize brain activations associated with two distinct language tasks performed by a 28-year-old woman after partial recovery from dysphasia due to a left frontal hemispheric ischemic stroke. MRI showed that her ischemic lesion extended posteriorly from the left inferior frontal to the perisylvian cortex. fMRI scans of both language tasks revealed substantial differences in activation pattern relative to controls. The nature of this difference was task-specific. During performance of a verbal semantic decision task, the patient, in contrast to controls, activated a network of brain areas that excluded the inferior frontal gyrus (in either hemisphere). A second task involving rhyme judgment was designed to place a heavier cognitive load on language production processes and activated the left inferior frontal gyrus (Broca's area) strongly in normal controls. During this task, the most prominent frontal activation in the patient occurred in the right homologue of Broca's area. Subsequent analysis of this data by methods able to deal with responses of changing amplitude revealed additional, less sustained recruitment by the patient of cortex adjacent to the infarct in the region inferior to Broca's area during rhyming. These results suggest that in addition to changes in cognitive strategy, recovery from dysphasia could be mediated by both the preservation of neuronal networks in and around the infarct and the use of homologous regions in the contralateral hemisphere.