Gender-Moderated Dorsolateral Prefrontal Reductions in 22q11.2 Deletion Syndrome: Implications for Risk for Schizophrenia

To investigate the impact of the microdeletion on morphology of the prefrontal cortex in 22q11.2 Deletion Syndrome (22q11.2 DS), high-resolution, anatomic magnetic resonance imaging was performed on 19 children and adolescents with 22q11.2 DS (11 females, 8 males) and 18 unaffected controls (10 females, 8 males). Tissue volumes of the dorsolateral, dorsomedial, orbitolateral, and orbitomedial prefrontal cortex were measured. Tasks of executive function and working memory were administered to investigate the association between anatomy and function. Whole brain volume and frontal lobe tissue volume were preserved in girls but reduced in boys with 22q11.2 DS relative to age-matched controls. Dorsolateral prefrontal cortex (DLPFC) volumes were reduced in participants with 22q11.2 DS, although the gender-by-diagnosis effect found for frontal lobe was not as robust for DLPFC. DLPFC volumes were associated with performance on tasks of planning and emotional facial recognition. Longitudinal studies are needed to clarify whether gender differences in frontal lobe and DLPFC persist with development, and whether the volumes of the DLPFC are associated with eventual deterioration in adaptive/psychosocial function that may presage the onset of schizophrenia, for which individuals with 22q11.2 DS are at a disproportionately high risk.     

On creating a psychoanalytic mind

The term process knowledge is introduced to highlight a particular way of analyzing that centers on how our patients gain knowledge. It is suggested that analyzing with heightened awareness to process knowledge is crucial for the patients' capacity for self-analysis, and differs from helping patients primarily gain knowledge of their unconscious fantasies and conflicts as the primary curative factor in psychoanalysis.     

CONSIDERATIONS ON DEPRESSIVE CONFLICT AND ITS DIFFERENT LEVELS OF INTENSITY: IMPLICATIONS FOR TECHNIQUE

This article considers the problem of depressive conflict (DC) and the difficulties that arise in integrating aggression towards the object of libidinal cathexis. This conflict results, in particular, from the destructive omnipotence that infantile fantasies attribute to the aggression. In order to better clarify Klein's very broad concept of the depressive position, three levels of severity of depressive conflict are proposed, depending on the type of fantasies concerning the loss of the object that predominate in the individual. These are: fantasies of catastrophic and irreparable destruction of the object ('parapsychotic' DC); fantasies of death and serious damage of the object ('para-depressive' DC); and fantasies of rejection and loss of the love of the object ('para-neurotic' DC). Having looked at these theoretical hypotheses, their implications for technique will then be considered, particularly the importance of focusing the interpretation on guilt feelings rather than on drives in the transferential relationship. A clinical example drawn from the work of Klein and a clinical vignette of a particularly difficult analysis illustrate this technical hypothesis.     

小学生视觉-空间表征类型和数学问题解决的研究

本研究考察并比较了四至六年级儿童的视觉－空间表征策略、数学问题解决和空间视觉化能力。结果表明：五、六年级儿童的解题正确率、使用图式表征策略的程度显著高于四年级儿童;使用图像表征策略的程度各年级无显著差异。将数学问题分成三个难度等级,发现年级差异主要表现在难度等级1的题目上。另外,六年级儿童的空间视觉化能力显著高于四年级儿童。     

Journal Reviews

Covington, Coline. 'Learning how to forget – repeating the past as a defence against the present'.
Grotstein, James. 'Bion, the Pariah of O'.
Hinshelwood, R. D. 'The elusive concept of "internal objects" (1934–1943): its role in the formation of the Klein Group'.
Lippmann, Paul. 'On dreams and interpersonal psychoanalysis'.
Renik, Owen. 'Conscious and unconscious use of the self'.
Schaverien, Joy. 'Men who leave too soon: reflections on the erotic transference and countertransference'.
Williams, Gianna, 'Reflections on some dynamics of eating disorders: "no entry" defences and foreign bodies'.
Slavin, Malcolm & Kriegman, D. 'Why the analyst needs to change: towards a theory of conflict, negotiation, and mutual influence in the therapeutic process'.     

Relationships between factors of intelligence and brain volume

The recent explosion of studies aimed at determining the biological basis of intelligence has revealed that cognitive ability has a strong biological substrate. This study expands on this literature by examining the relation between cognitive ability and MRI-measured brain volume and head size in a sample of adult male siblings recruited from the London, Ontario community in Canada. It was found that brain volume correlated with IQ at 0.35 (P<0.01), thus replicating the results of past studies. Corrections for restriction of range and attenuation in both this and past studies suggest that the population value of the brain volume-IQ correlation is closer to 0.50. Head size variables, with one exception, also showed the expected positive correlations with IQ. The results of a vector analysis on factor scores indicated that the more highly g-loaded a test was the more highly it correlated with brain volume (r=0.59, P<0.01). The sum of the data suggested that although brain volume (and to a lesser extent, head size) is predictive of g, fluid ability, and memory, it does not predict crystallized ability. Unexpectedly, the higher the spatial imaging loading of a test, the less its correlation with brain volume (vector correlation=−0.84, P<0.001).     

不同结构文章重复阅读时主题转换效应的眼动研究

选取36名大学生,运用眼动技术,探讨不同结构类型文章在重复阅读时主题转换效应的变化特点。被试阅读的材料有两类:一是段落内部各个句子之间为平行关系(平行材料);一是每段第一个句子为该段落主题句(总分材料)。结果发现,两类材料在第一遍阅读过程中均出现了显著的主题转换效应,但在重复阅读时,主题转换效应消失,说明读者在第一遍阅读时已构建了文章的主题结构表征,并以此来指导后面的阅读。该结果支持共同策略假设理论,说明无论文章中是否存在标记,读者在阅读时都会构建一定完善的主题结构表征。     

Stupidity in the analytic field: Vicissitudes of the detachment process in adolescence

This paper has the objective of broadening the understanding of technical aspects in working with adolescents who defend themselves against detachment from infantile aspects through defensive organizations. These organizations numb the adolescent toward both triangular reality and narcissistic defenses. The families of such young people may be part of the organization and the analyst can also be recruited to participate in it. But the analyst's perception can become blurry and this fact makes him appear stupid. Aspects of the myths of Narcissus and Oedipus are used here as models for studying stupidity. The analysis of a psychotic teenage girl who is symbiotic in relation to her family shows how the analytical field can be invaded by defensive configurations. Collusions of idealization and domination/submission involve the young person, her family and the analyst but the defensive organizations are only identified after their traumatic breakdown. The expansion of the symbolic network allows symbiotic transgenerational organizations to be identified, while models related to enactments prove helpful for understanding technical ups and downs. The paper ends with imaginative conjectures where Oedipus, as ‘patient’, is compared to the patient discussed here. These conjectures lead to reinterpretations of aspects of the Oedipus myth. The reinterpretations, together with the theoretical and clinical study, may serve as models for understanding the technical ups and downs in working with troubled teens.     

核移植技术应用的问题及前景

自从核移植产生第一头克隆羊多莉以来,对其应用一直存在争议。尽管核移植技术存在各方面的问题和不足,如伦理学方面的问题,技术方面的不成熟以及该技术对生物物种质量和生存能力的影响。但核移植技术正在不断被人们接受,并已用于治疗性克隆和动物实验研究。随着人们观念的改变和技术的不断完善,核移植技术的应用范围将不断扩大,具有广阔的应用前景。