Gender-Moderated Dorsolateral Prefrontal Reductions in 22q11.2 Deletion Syndrome: Implications for Risk for Schizophrenia

To investigate the impact of the microdeletion on morphology of the prefrontal cortex in 22q11.2 Deletion Syndrome (22q11.2 DS), high-resolution, anatomic magnetic resonance imaging was performed on 19 children and adolescents with 22q11.2 DS (11 females, 8 males) and 18 unaffected controls (10 females, 8 males). Tissue volumes of the dorsolateral, dorsomedial, orbitolateral, and orbitomedial prefrontal cortex were measured. Tasks of executive function and working memory were administered to investigate the association between anatomy and function. Whole brain volume and frontal lobe tissue volume were preserved in girls but reduced in boys with 22q11.2 DS relative to age-matched controls. Dorsolateral prefrontal cortex (DLPFC) volumes were reduced in participants with 22q11.2 DS, although the gender-by-diagnosis effect found for frontal lobe was not as robust for DLPFC. DLPFC volumes were associated with performance on tasks of planning and emotional facial recognition. Longitudinal studies are needed to clarify whether gender differences in frontal lobe and DLPFC persist with development, and whether the volumes of the DLPFC are associated with eventual deterioration in adaptive/psychosocial function that may presage the onset of schizophrenia, for which individuals with 22q11.2 DS are at a disproportionately high risk.     

Use of verbal pain measurement in the detection of hidden psychological morbidity among low back pain patients with objective organic findings

Abstract

Patients with positive physical findings to explain low back pain arc believed lo belong to two organic subgroups. One group has organic disease alone: in the other, organic disease is accompanied by psychological disturbance. Separation of patients with medical findings into groups with varying levels of psychological disturbance is difficult, because emotional disturbance is often hidden. In this study, the pain report of 124 patients with organic findings alone, and 50 patients with organic and psychological findings was examined to determine whether pain measurement could he used to identify accurately patients belonging 10 the two groups. the pain groups differed in the use of 43 pain words from the Low Back Pain Symptom Check List. Using a set of weights derived From discriminant analysis. the 33 pain words predicted 99.2% of the patients with organic disease alone and 86.0% of the patients with organic disease and psychological disturbance. The results were replicated in a new sample of 140 patients. Cross-validation shrinkage in accuracy was 8.3%. The results of the two studies suggest that pain measurement may he a useful clinical indicator of psychological disturbance in patients with organic findings.     

Multicriteria Classification with Unknown Categories: A Clustering–Sorting Approach and an Application to Conflict Management

This work proposes an approach to cluster and sort a set of alternatives considering multi‐criteria categories with a partial order structure. It can be considered a heuristic approach because it does not attempt to derive an optimal partial order among all conceivable clusters of alternatives. Rather than this, it intends to be a simple approach that is transparent to the Decision Maker (DM) whose assistance is sought to help shaping the results. The approach proposed arises from the conjugation of traditional Clustering analysis and Multi‐criteria sorting tools. At the outset, the number of categories and their characteristics is unknown. First, we need to detect only the clusters themselves on the basis of a similarity measure independent of the preferences of the DM. Next, we detect potential partial order relations that might exist between them, according to the subjective preferences of the DM. Such preferences are elicited only after the DM has examined the clusters detected and deemed that these categories made sense. The new approach performs very well in a real‐world problem of management of intragroup conflicts and conflict handling strategies. Copyright © 2012 John Wiley & Sons, Ltd.     

Mind-reading without the scanner: Behavioural decoding of working memory content

ABSTRACT

Sophisticated machine learning algorithms have been successfully applied to functional neuroimaging data in order to characterize internal cognitive states. But is it possible to “mind-read” without the scanner? Capitalizing on the robust finding that the contents of working memory guide visual attention toward memory-matching objects, we trained a multivariate pattern classifier on behavioural indices of attentional guidance. Working memory representations were successfully decoded from behaviour alone, both within and between individuals. The current study provides a proof-of-concept for applying machine learning techniques to simple behavioural outputs (e.g., response times) in order to decode information about specific internal cognitive states.     

Koran reading and negotiation with jinn: strategies to deal with mental ill health among Swedish Somalis

In this paper, we discuss traditional Somali concepts of mental ill health. Qualitative interviews were conducted with some 20 Swedish Somali interviewees about factors causing mental ill health, traditional classification, strategies to deal with mental ill health, and attitudes to the mental health care services in Sweden. Social mobilisation and religious healing are cornerstones of traditional Somali measures to deal with mental suffering. Traditional Somali views of mental ill health stand in stark contrast to classification of mental ill health in the western biomedical model. These views deserve attention since they may have an impact on health-seeking behaviour among Somali immigrants in western countries. Yet a too strong focus on cultural aspects may over-shadow the fact that much mental suffering among Somali migrants must be understood within social, economic, and political contexts.     

Sport and the obligation of solidarity

The paper departs from an analysis of the case of Michelle Dumaresq, a transgender female downhill mountain biker who experienced marginalization within her sport. The analysis is based on Axel Honneth’s theory of recognition. The Dumaresq case is particularly relevant to Honneth’s ideas of solidarity, which provide insight into the dynamics of social integration. Honneth’s theory of recognition also provides a conceptual framework and a methodology that gives new perspectives on the ethical significance of sport. In the paper, an analysis is presented of the lack of solidarity experienced by Dumaresq. The argument is made that sport has a particular potential for realizing solidarity among its practitioners. Realizing solidarity however depends to a large degree upon that the rules of sport are perceived as fair and just. In the Dumaresq case, challenges to solidarity came from what her competitors considered to be unfair classification rules. Summing up, it is argued that, as long as the rules of a sport is perceived as fair and just, voluntary engagement gives rise not only to obligations on fair play but to a moral obligation on solidarity as well.     

易学的推类逻辑

易学中的逻辑问题,是一个在易学和逻辑学研究中被忽视的问题,但又是一个关系到对中国文化史、思想史和逻辑史的再认识的重要问题。易学中的逻辑是推类逻辑,本文给出了理由,同时以现代逻辑的方法给出了易学推类逻辑的形式系统,并作了讨论。指出易学逻辑是在中国文化背景下的以汉字表述的特有逻辑形式,建立了中国古代的普遍语言,形成了自我满足的语义系统,其在为人们提供正确的认识方法和为古代科学提供认识工具方面与西方逻辑是一致的。     

Age and Education Differences in Marriages and their Effects on Life Satisfaction

Within marriages husbands typically tend to be older and higher educated than their wife. This paper tries to explain this by analyzing whether age and education differences between spouses have an effect on happiness. Two alternative hypotheses are tested on the relation between age and education gaps between partners and life satisfaction. It is found that a positive age gap between husband and wife increases both male and female life satisfaction, while female life satisfaction increases if the education gap is smaller.     

背景知识对4~8岁儿童和大学生分类活动的影响

以4-8岁儿童和大学生为被试,用虚拟生物图片为材料,采用2(不提供背景知识和提供背景知识)×6(年龄)的实验设计,考察背景知识对被试分类活动的影响及其年龄特点。结果发现:(1)两种实验条件下均有显著的年龄差异。(2)提供背景知识与否对不同年龄被试分类活动的影响不同,对4-5岁儿童分类活动的影响不显著,对6-8岁儿童及大学生分类活动的影响显著。     

Human factors of transitions in automated driving: A general framework and literature survey

The topic of transitions in automated driving is becoming important now that cars are automated to ever greater extents. This paper proposes a theoretical framework to support and align human factors research on transitions in automated driving. Driving states are defined based on the allocation of primary driving tasks (i.e., lateral control, longitudinal control, and monitoring) between the driver and the automation. A transition in automated driving is defined as the process during which the human-automation system changes from one driving state to another, with transitions of monitoring activity and transitions of control being among the possibilities. Based on ‘Is the transition required?’, ‘Who initiates the transition?’, and ‘Who is in control after the transition?’, we define six types of control transitions between the driver and automation: (1) Optional Driver-Initiated Driver-in-Control, (2) Mandatory Driver-Initiated Driver-in-Control, (3) Optional Driver-Initiated Automation-in-Control, (4) Mandatory Driver-Initiated Automation-in-Control, (5) Automation-Initiated Driver-in-Control, and (6) Automation-Initiated Automation-in-Control. Use cases per transition type are introduced. Finally, we interpret previous experimental studies on transitions using our framework and identify areas for future research. We conclude that our framework of driving states and transitions is an important complement to the levels of automation proposed by transportation agencies, because it describes what the driver and automation are doing, rather than should be doing, at a moment of time.