2型糖尿病大血管病变机理和糖尿病治疗

2型糖尿病大血管病变与代谢综合征密切相关.现代医学认为两者的根本原因是胰岛素抵抗,导致糖耐量下降,血脂紊乱,高胰岛素血症,高血压和高凝状态等.从系统论的观点阐述了代谢综合征的相互关系和2型糖尿病大血管病变发病机理,并进一步从该观点阐明2型糖尿病的防治策略.     

第二语言语义提取中的工作记忆效应

本文报告一项针对工作记忆容量是否制约中国英语学习者第二语言语义提取效率的实验。实验考查了工作记忆广度中的个体差异是否抑制学习者对第二语言单词语义信息的提取问题,还探索了工作记忆广度和第二语言词汇知识水平的相关性。研究以通用容量工作记忆模型为基础,采用运算广度的工作记忆测试,得出工作记忆广度对单词语义信息的提取没有显著抑制作用的结果。结果还显示工作记忆广度与第二语言词汇知识水平之间没有显著的线性关系。     

Time-course of hemispheric preference for processing contralateral relevant shapes: P1pc, N1pc, N2pc, N3pc

A most sensitive and specific electrophysiological indicator of selective processing of visual stimuli is the N2pc component. N2pc is a negative EEG potential peaking 250 ms after stimulus onset, recorded from posterior sites contralateral to relevant stimuli. Additional deflections preceding or following N2pc have been obtained in previous studies, possibly produced by specific stimulus features or specific prime-target sequences. To clarify the entire time-course of the contralateral- ipsilateral (C-I) difference recorded from the scalp above visual cortex in response to left-right pairs of targets and distracters, C-I differences were here compared between two types of stimuli and between stimuli that were or were not preceded by masked neutral primes. The C-I difference waveform consisted of several peaks, termed here P1pc (60-100 ms after target onset), N1pc (120-160 ms), N2pc (220-280 ms), and N3pc (360-400 ms). Being markedly enhanced when stimuli were preceded by the neutral primes, P1pc may indicate a response to stimulus change. Also, when stimuli were primed, N2pc reached its peak earlier, thereby tending to merge with N1pc. N3pc seemed to increase when target discrimination was difficult. N1pc, N2pc, and N3pc appear as three periods of one process. N3pc probably corresponds to L400 or SPCN as described in other studies. These observations suggest that the neurophysiological basis of stimulus-driven focusing of attention on target stimuli is a process that lasts for hundreds of milliseconds, with the relevant hemisphere being activated in an oscillating manner as long as required by the task.     

糖尿病教育在2型糖尿病防控工作中的重要性

近年来,由于糖尿病的高患病率、高致残率和高死亡率带来沉重的社会和经济负担。预防糖尿病发生、改善糖尿病患者现况等均提示推广普及糖尿病教育具有重要意义。通过糖尿病教育可以全面改善患者临床控制指标、知识水平、自我管理水平和自我效能水平,且从卫生经济学角度分析显示其投入相对较小的成本即可达到良好的效果和效用,因而在糖尿病防控体...     

OSAHS在2型糖尿病发病中的作用与对策

阻塞性睡眠呼吸暂停综合征（obstructive sleep apnea hypopnea syndrome,OSAHS）是一种常见的睡眠呼吸紊乱性疾病,以睡眠时反复发作的上气道部分或完全阻塞为特征。近年发现OSAHS与2型糖尿病之间有着明显的相关性,二者均为心血管疾病的高危因素,合并存在能够严重影响生命质量与预期寿命...     

Enhanced learning by posttrial injection of H1-but not H2-histaminergic antagonists into the nucleus basalis magnocellularis region

The aim of this study was to examine the effects of histaminergic antagonists on memory upon injection into the region of the nucleus basalis magnocellularis (NBM). In experiment 1, rats with chronically implanted cannulae were trained on the uphill avoidance task, which involves a punishment of a high-probability turning response on a tilted platform (negative geotaxis). Immediately after the training trial, that is, after a tail shock was administered upon performing the response, rats received one microinjection (0.5 microliter) of H1-receptor blocker chlorpheniramine (dose range 0.1 to 20 microgram) or the H2-receptor blocker ranitidine (same dose range) or saline into the NBM region. When tested 24 h later, rats treated with chlorpheniramine (20 micrograms) had significantly longer uphill latencies than vehicle controls and ranitidine-treated animals, indicative of superior learning of the avoidance response. In experiment 2, a test for possible proactive effects of posttrial chlorpheniramine on performance during the retention trial was performed. Animals were injected with either 20 micrograms chlorpheniramine or saline immediately after the training trial of the uphill task. One chlorpheniramine control group was treated with a delay of 5 h. Additional groups which received chlorpheniramine or vehicle after the training trial but no trail shock were included. When tested 24 h later, rats injected with 20 micrograms chlorpheniramine again exhibited significantly longer uphill latencies than did vehicle-injected rats. Retention latencies for the rats of the chlorpheniramine 5-h delayed group did not differ from those of the vehicle-injected rats, ruling out proactive effects of chlorpheniramine on performance. In summary, the histaminergic H1-blocker chlorpheniramine can enhance mnemonic functioning in addition to its reinforcing effects upon NBM injection as reported previously.     

厌恶与恐惧情绪习得的性别差异研究:一项ERP研究

采用事件相关电位技术（ERPs）,用条件性习得范式探讨厌恶与恐惧情绪习得的性别差异。行为结果表明,在成功习得厌恶、恐惧和中性情绪之后,男女性在唤醒度维度上,性别差异显著;脑电结果表明,在早期N1和P2成分,厌恶情绪与恐惧情绪的习得无显著性别差异;但男女不同性别在N2成分上差异显著,主要表现为女性在厌恶、恐惧、中性这三类CS的N2成分均差异显著,但男性仅厌恶与中性情绪的CS差异显著。结果表明在负性情绪的习得中,女性比男性更敏感。     

The inclosure scheme and the solution to the paradoxes of self-reference

Proponents of the explanatory gap claim that consciousness is a mystery. No one has ever given an account of how a physical thing could be identical to a phenomenal one. We fully understand the identity between water and H₂O but the identity between pain and the firing of C-fibers is inconceivable. Mark Johnston [Journal of philosophy (1997), 564–583] suggests that if water is constituted by H₂O, not identical to it, then the explanatory gap becomes a pseudo-problem. This is because all “manifest kinds”—those identified in experience—are on a par in not being identical to their physical bases, so that the special problem of the inconceivability of ‘pain = the firing of C-fibers’ vanishes. Moreover, the substitute relation, constitution, raises no explanatory difficulties: pain can be constituted by its physical base, as can water. The thesis of this paper is that the EG does not disappear when we substitute constitution for identity. I examine four arguments for the EG, and show that none of them is undermined by the move from constitution to identity.