Quantitative CT scan studies in aphasia. I. Infarct size and CT numbers

Infarct si?e (number of 1-mm² pixels in the lesion) on CT scans of 30 aphasia patients was obtained with a semiautomated computer program. The mean number of lesion pixels present per slice containing lesion was approximately 500 for mild aphasias (transcortical motor and conduction), 700 for Wernicke's, 1000 for Broca's, 1500 for mixed, and 2000 for globals. These differences were significant for $\text{11}\text{15}$ of the group pairwise comparisons. When lesion locus was controlled for in the anterior/posterior plane, 73–100% of the aphasia patients were correctly classified as to type of aphasia by a discriminant analysis utilizing only the number of lesion pixels present on two CT slices. Different slice combinations were used for different aphasia group comparisons. There was a significant correlation between severity of aphasia and lesion size. There was a significant correlation between lesion size and the CT numbers in the lesion. This type of analysis may be useful to predict the prognosis for recovery potential in aphasics who have CT scans performed at 2 months poststroke.     

The precise time course of lexical activation: MEG measurements of the effects of frequency, probability, and density in lexical decision

Visually presented letter strings consistently yield three MEG response components: the M170, associated with letter-string processing (Tarkiainen, Helenius, Hansen, Cornelissen, & Salmelin, 1999); the M250, affected by phonotactic probability, (Pylkk?nen, Stringfellow, & Marantz, 2002); and the M350, responsive to lexical frequency (Embick, Hackl, Schaeffer, Kelepir, & Marantz, 2001). Pylkk?nen et al. found evidence that the M350 reflects lexical activation prior to competition among phonologically similar words. We investigate the effects of lexical and sublexical frequency and neighborhood density on the M250 and M350 through orthogonal manipulation of phonotactic probability, density, and frequency. The results confirm that probability but not density affects the latency of the M250 and M350; however, an interaction between probability and density on M350 latencies suggests an earlier influence of neighborhoods than previously reported.     

The role of need level and/or need salience as moderators of the relationship between need satisfaction and work alienation-involvement

Contrary to previous findings documenting the importance of higher-order need satisfaction, a recent study by G. J. Gorn and R. N. Kanungo (Organizational Behavior and Human Performance, 1980, 26, 265–277) has indicated that satisfaction of lower-order needs may lead to job involvement if such needs are salient. Data from a heterogeneous sample of 632 employees from six organizations were used to test six hypotheses concerning the effects of need level (higher vs lower order) and need salience as moderators of the relationship between need satisfaction and alienation-involvement. Three different ways of operationalizing need saliency were used, including a replication of Gorn and Kanungo's procedure. Higherorder need satisfaction was correlated with alienation-involvement scores to a significantly greater degree than was lower-order need satisfaction, even for those for whom lower-order needs were most salient. Need saliency was not found to moderate the need satisfaction-involvement relationship when need level was controlled. Issues regarding the operationalization of “need salience” were discussed and a new measure of alienation-involvement (the A-I Scale) was introduced. Implications for further empirical investigations of the need saliency issue were noted, as was the universal application of job enrichment programs aimed at promoting higher-order need satisfaction.     

Intrusions and perseverations

Twenty-two subjects with presumed senile dementia of the Alzheimer's type (SDAT), twenty-two with dementia other than SDAT, twenty with aphasia, and seventeen healthy controls over 50 years of age were examined for intrusions and perseverations. Perseverations were defined as the immediate inappropriate repetition of a prior response whereas intrusions were defined as the inappropriate repetition of prior responses after intervening stimuli. Intrusions and perseverations occurred in demented and aphasic subjects, but were rare in controls. Intrusions occurred most often in SDAT or Wernicke aphasia, but also in dementia other than SDAT. Intrusions were not correlated with dementia severity. Intrusions are a useful sign of dementia, but they cannot be considered pathognomonic of SDAT. They appear to arise when subjects are unable to access correct responses from long-term memory and instead substitute erroneous responses selected from short-term memory. Perseverations were most common in the Wernicke aphasics and subjects with dementia due to communicating hydrocephalus. Although frontal lobe dysfunction is prominent in communicating hydrocephalus, it is absent in cases of Wernicke aphasia. Thus, we have confirmed prior suggestions that perseveration can occur in the absence of frontal lobe injury. Failure to self-monitor speech as well as an inability to change mental set probably plays an important role in the genesis of perseverations. There was no statistically significant correlation between dementia severity and number of perseverations. Low correlations were found between intrusions and perseverations suggesting that these seemingly similar behaviors are distinct and are probably produced by separate neuropsychological mechanisms.     

Left-hemisphere language lateralization in bilinguals: use of the concurrent activities paradigm

Previous visual and auditory lateralization studies have demonstrated that the languages of bilinguals are lateralized to the left hemisphere to the same extent as in monolingual controls (C. Soares & F. Grosjean, 1981, Perception and Psychophysics, 29, 599-604; C. Soares, 1982, Neuropsychologia, 20, 653-659). The present study tested the same group of Portuguese-English bilinguals and a group of English-speaking monolinguals on a series of concurrent activity, or time-sharing, tasks. Greater levels of disruption in finger tapping with the right hand than with the left hand occurred during the performance of those tasks which required overt speech production, and this for both bilinguals and monolinguals. As in the previous studies, there were no lateralization differences across the bilinguals' two languages or between bilinguals and monolinguals. Thus, further evidence for equal levels of left-hemisphere dominance for language in bilinguals and monolinguals was provided by the use of the concurrent activities paradigm.     

Right-hemispheric language evidence from cortical stimulation

While the left-hemispheric dominance for language in most right-handers is unquestionable, clinical observations suggest that the right, nondominant hemisphere has a considerable capacity for language. Under certain neuroanatomical conditions, the right-hemispheric capacity becomes functional and, thus, measurable. This study focuses on evoked language responses during electrical stimulation of the right hemisphere in three left-dominant patients undergoing temporal lobe resections for medically intractable seizures.     

Speeded recognition of ungrammaticality: Double violations

A model of sentence comprehension postulating that Subject-Verb-Object relations are specified prior to Noun-Adjective relations received support from a study of the speed at which sentences with various kinds of violations could be rejected. Compatible with the sequential model was the finding that Noun-Verb and Adjective-Noun double violations did not result in shorter RTs than Noun-Verb single violations — even though sentences with double violations were judged to be less acceptable.     

A new processing model for predicting performance on Pascual-Leone's test of M-space

A new model is proposed for explaining children's performance on Pascual-Leone's test of M-space. The model differs from Pascual-Leone's in three regards. (1) It assumes that children do not stop sampling a compound stimulus until every simple stimulus in their field of attention has already been noticed and responded to. (2) It assumes that the probability of sampling different combinations of simple stimuli conforms to the laws of Maxwell-Boltzman statistics rather than Bose-Einstein statistics. (3) It assumes that children's ability to detect all the simple stimuli in a compound stimulus is highly dependent both on the relative saliencies of the simple stimuli and on the length of time for which the compound stimulus is exposed. Using the developmental values of M hypothesized by Pascual-Leone, and standard techniques of computer simulation, the new model is used to generate theoretical performance curves for children at four different age levels and seven different levels of stimulus complexity. It is shown that the predicted performance curves for an exposure time of 5 sec provide a reasonable fit to the data originally reported by Pascual-Leone (1970), and that the predicted performance curves for an exposure time of 10 sec provide a reasonable fit to data obtained more recently by Parkinson (1976). Finally, it is shown that the order of children's responses as well as the number of their responses can be predicted. Two conclusions are drawn. (1) The new processing model offers a viable alternative to the model originally proposed by Pascual-Leone. (2) Regardless of which processing model is employed, the M-values originally postulated by Pascual-Leone are valid.     

A within-subject analysis of stimulus control therapy with severe sleep-onset insomnia.

Stimulus control, a behavioral technique designed to reduce sleep difficulties, has been demonstrated to be effective when compared with control procedures. These comparisons, mainly involving between-subjects analyses, have neglected the contribution of the stimulus control procedure to the production of clinically significant amelioration of sleep dysfunction. In contrast, the present within-subjects experiment was conducted to assess the capability of stimulus control to produce clinically relevant reductions in multiple measures of sleep disturbance. A comparison with the credible placebo procedure indicated that the stimulus control techniques reduced subjects' sleep onset latency to a mean latency below 30 min per week. Additionally, sedative-hypnotic usage was greatly reduced.