Speech comprehension after unilateral injection of sodium amytal

A unilateral cerebral dominance model predicts that speech comprehension will be disrupted after injection of sodium amytal into one hemisphere but not after the other. This model was supported when an auditory receptive task involving relatively nonredundant stimuli similar to that contained in the Token Test (E. DeRenzi & L. Vignolo, 1962, Brain, 85, 665–687) was administered to 17 epileptic patients undergoing bilateral amytal injections.     

Message therapy: Language approach to stuttering therapy with children

Message therapy is a clinical procedure designed to be used as a carry-over technique with school-age stutterers or as a sole technique with the preschooler. The focus of therapy is on a unit of communication rather than on the moment or place of stuttering. One of the basic assumptions of the procedure is that the child is beginning to monitor how he/she is speaking rather than what is being communicated (i.e., the “message”)—each task requiring a different cognitive process. The emphasis of the therapy is to redirect the child's attention to “what he/she is saying.” The clinical procedures are discussed as they relate to the specific population.     

Dissociable stages of problem solving (II): first evidence for process-contingent temporal order of activation in dorsolateral prefrontal cortex

In a companion study, eye-movement analyses in the Tower of London task (TOL) revealed independent indicators of functionally separable cognitive processes during problem solving, with processes of building up an internal representation of the problem preceding actual planning processes. These results imply that processes of internalization and planning should also be distinguishable in time and space with respect to concomitant brain activation patterns. To investigate this possibility, here we conducted analyses of fMRI data for left and right dorsolateral prefrontal cortex (dlPFC) during problem solving in the TOL task by accounting for the trial-by-trial variability of onsets and durations of the different cognitive processing stages. Comparisons between stimulus-locked and response-locked modeling approaches affirmed that activation in left dlPFC was elicited particularly during early processes of internalization, comprising the extraction of goal information and the generation of an internal problem representation, whereas activation in right dlPFC was predominantly attributable to later processes of mental transformations on this representation, that is planning proper. Thus, present data corroborate the proposal that often observed bilateral dlPFC activation patterns during complex cognitive tasks such as problem solving may reflect functionally and, to some extent, even temporally separable processes with opposing lateralizations.     

Dissociable stages of problem solving (I): temporal characteristics revealed by eye-movement analyses

Understanding the functional neuroanatomy of planning and problem solving may substantially benefit from better insight into the chronology of the cognitive processes involved. Based on the assumption that regularities in cognitive processing are reflected in overtly observable eye-movement patterns, here we recorded eye movements while participants worked on Tower of London (TOL) problems that comprised an experimental manipulation of different task demands. Single-trial saccade-locked analyses revealed that higher demands on forming an internal problem representation were associated with an increased number of gaze alternations between start state and goal state, but did not show any effect on the durations of these inspections of the states. In contrast, higher demands on actual planning in terms of mental manipulations of working memory contents coincided with a prolonged duration of the very last inspection of the start state (i.e., immediately preceding movement execution) but did not show any effect on the number of gaze alterations. Differential task demands on internalization and planning processes during problem solving hence selectively affect different eye-movement parameters. Moreover, these findings complement previous neuroimaging data on dissociable contributions of left and right dorsolateral prefrontal cortex in problem solving with novel evidence for a corresponding dissociation in the eye-movement patterns reflecting the associated cognitive processes.     

Robert Singleton's Sermon at Paul's Cross in 1535: The ‘True Church’ and the Royal Supremacy

Abstract

On 2 April 1535, Robert Singleton, chaplain to Queen Anne Boleyn, preached a sermon at Paul's Cross. The unique, surviving printed copy of the sermon is housed in the Wren Library of Lincoln Cathedral. From 1533, Singleton had been a member of the circle of avant-garde evangelicals gathered at the margins of the Tudor court under the patronage of Thomas Cromwell. His sermon at Paul's Cross contributed to an orchestrated campaign in support of Cromwell's legislative programme, then proceding through Parliament, to sever all links of ecclesiastical jurisdiction with Rome and to confirm Henry's headship of the Church of England. The sermon interprets Paul's allegory of the earthly and the heavenly Jerusalem in the Epistle to the Galatians as a model for thinking about the distinction between the invisible and visible Church. Singleton harnesses Pauline ecclesiology in an apology for the royal supremacy. Presented here is a transcribed copy of the original printed version.