Pharmacotherapy of schizophrenia and affective disorders: Behavioral assessment of psychiatric medications

Objectively defined, publicly observable ward behaviors (body activity, extremity activity, scanning, social interaction, proximity, participation, laughing/smiling, and idiosyncratic behavior) emitted by psychiatric inpatients with either schizophrenic or affective disorders were time sampled both before and during the administration of psychiatric medications (neuroleptics, tricyclics, and lithium). The data indicate that the primary effects of the pharmacological interventions are confined to activity measures and symptoms rather than social behaviors. The implications of these results for treatment protocols are discussed in terms of interactions between pharmacological and psychosocial interventions. In addition, rates of behavior during treatment were related to baseline rates via a log-log function of negative slope, a result that is consistent with data derived from the infrahuman laboratories. Taken together the results provide support for attempts to relate preclinical and clinical psychopharmacology and suggest that behavioral assessment can be applied profitably to drug effects in clinical situations.These investigations were supported in part by State of Illinois Department of Mental Health and Developmental Disabilities Grants RD836-13 and RD622-02 to the first author. The cooperation of the Illinois State Psychiatric Institute staff is gratefully acknowledged. Assistance in data collection was provided by S. Sussman and K. Mueser.     

Pharmacological and Behavioral Strategies for Smoking Cessation

After over two decades of intensive research, a variety of smoking cessation strategies, both behavioral and pharmacotherapeutic, have been developed and clinically validated. In this review, pharmacological products available for smoking cessation are profiled and examined for efficacy. Results of a recent comprehensive review and meta-analysis by the Agency for Health Care Policy and Research on the effects of behavior therapy on smoking cessation are also discussed. Further, meta-analyses and studies exploring the important interaction between pharmacological and behavioral therapies are considered. Applications of the growing wealth of smoking cessation strategies are discussed with respect to the needs of some special subpopulations of smokers including highly nicotine-dependent smokers and smokers with comorbid psychiatric diagnoses.     

Source dependence in the valuation of objects

We ran two experiments to test whether people value objects more highly when they obtain those objects due to exemplary performance at a task. In the first, subjects who believed they had obtained a prize due to their performance on a classroom exercise valued it more highly than those who believed they had obtained it by chance. In the second, subjects who obtained a prize due to exemplary performance on a task valued it more highly than those who obtained it due to their poor performance. In both experiments, this ‘source dependence’ effect is approximately equal in strength to the endowment effect, which compares the valuation of subjects with and without the prize. We suggest a possible explanation for this source-dependence effect based on associationism, and rule out two alternative explanations.     

冲动性对不同成瘾行为发展的调控及其神经机制

近年来越来越多的研究证据提示, 个体冲动性在成瘾疾患发生发展机制中具有关键作用, 可能成为成瘾行为的潜在易感标记以及早期识别和干预的重要靶点, 但冲动性对不同成瘾行为变化发展的调控机制尚不明确。项目拟综合跨成瘾谱系比较、纵向追踪设计、冲动行为干预等研究途径, 采用人格测量、神经认知、神经影像等技术, 首先比较尼古丁依赖者与网络游戏成瘾者的冲动性结构及其在前额叶–纹状体环路的结构功能改变; 然后采用混合分组设计筛选出具有高低冲动性的非成瘾青少年进行连续追踪研究, 考察冲动性对尼古丁依赖与网络游戏成瘾的预测效力; 并采用认知行为训练, 对吸烟成瘾者与网络游戏成瘾者进行冲动干预, 考察行为干预对冲动性水平及前额叶–纹状体环路功能的改变, 以及对不同成瘾行为发展的抑制后效。旨在探索冲动性作为成瘾的潜在易感标记及干预靶点的效力。     

大学生手机互联网依赖对疏离感的影响：社会支持系统的作用

为探讨大学生手机依赖、现实社会支持、网络社会支持及疏离感的关系。采用大学生手机成瘾倾向量表、青少年疏离感量表、大学生网络社会支持量表和青少年社会支持量表对442 名大学生进行测量。结果发现：（1）不同手机依赖水平与疏离感差异显著,高手机依赖者的疏离感均显著高于低手机依赖者;（2）手机依赖对疏离感有显著正向预测作用,网络社会支持和现实社会支持对疏离感有显著负向预测作用;（3）现实社会支持在手机依赖与疏离感间具有中介效应和调节效应,手机依赖既直接对疏离感产生影响,又通过现实社会支持对疏离感产生影响,中介效应占总效应的比例为17.8%;（4）现实社会支持和网络社会支持在手机依赖与疏离感间均具有调节效应,可以缓冲手机依赖对疏离感的影响。     

Heteroscedasticity as a Basis of Direction Dependence in Reversible Linear Regression Models

Heteroscedasticity is a well-known issue in linear regression modeling. When heteroscedasticity is observed, researchers are advised to remedy possible model misspecification of the explanatory part of the model (e.g., considering alternative functional forms and/or omitted variables). The present contribution discusses another source of heteroscedasticity in observational data: Directional model misspecifications in the case of nonnormal variables. Directional misspecification refers to situations where alternative models are equally likely to explain the data-generating process (e.g., x → y versus y → x). It is shown that the homoscedasticity assumption is likely to be violated in models that erroneously treat true nonnormal predictors as response variables. Recently, Direction Dependence Analysis (DDA) has been proposed as a framework to empirically evaluate the direction of effects in linear models. The present study links the phenomenon of heteroscedasticity with DDA and describes visual diagnostics and nine homoscedasticity tests that can be used to make decisions concerning the direction of effects in linear models. Results of a Monte Carlo simulation that demonstrate the adequacy of the approach are presented. An empirical example is provided, and applicability of the methodology in cases of violated assumptions is discussed.     

Controlling the uncontrollable. Self-regulation and the dynamics of addiction

The multidisciplinary research on addictions generally promotes the assumption that addictive behavior is caused and maintained by the external psychoactive substance, which accordingly is considered to be ‘addictive in itself’. The present article challenges this widespread assumption by engaging in a detailed examination of the psychodynamic structures of addiction. Tracing addictive behavior back to problems in affect regulation, the article discusses the object, motivation, dynamics, and developmental origins of addiction. Linking the problem with the topic of transitional object relations, the article eventually argues that addictive behavior amounts to a desperate pursuit for self-control. The tragedy of the addict is that he or she only manages to replace one sense of uncontrollability with another.     

Perceived impact of online written feedback on students’ writing and learning: a reflection

In this reflective study, I perceive the impact of my own written feedback on students’ academic writing skills in particular and on learning in general. Anchored on Schon’s reflection-on-action (ROA) framework, my reflection arose from a content analysis of my written feedback on 80 student drafts and 44 feedback responses. I found that my written feedback is of two types: focus on form and focus on meaning. Coding the feedback led to an identification of six feedback functions: instructive/using imperatives (18.36%); suggestive (15.31%); asking questions/probing (23.98%); stating a personal opinion (6.12%); corrective (29.59%); and affirming/negating (6.63%). The categorisation of feedback according to these functions was influenced by Wolsey’s feedback functions (2008) which was adapted by Alvarez, Espasa and Guasch. Results revealed that I employ corrective feedback, probing questions and instructive feedback more frequently than suggestive feedback, personal statement or affirmation/negation. I also found that my feedback on form (59%) is higher than my feedback on meaning (41%). I explain the relationship of these findings by identifying some confounding factors that enabled me to interrogate my assumptions, along with a discussion of their implications.