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21.
Fulvio Marzatico Laura Bertorelli Orietta Pansarasa Paola Guallini Carla Torri Giuseppe Biagini 《International journal of stress management》1998,5(4):223-236
We studied the role of free radicals on brain oxidative damage in rats after acute immobilization stress (restraint) and mild emotional stress (handling). To investigate brain oxidative damage, CuZn and Mn dependent superoxide dismutase (CuZn SOD, Mn SOD) activities, lipid peroxidation (TBARs), Na
+
K
+
ATPase activity, protein carbonyl (PrC), and reduced and oxidized glutathione (GSH, GSSG) levels were measured in the cerebral cortex (CTX), hippocampus (HIP), and striatum (ST) of the animals after the two different stress stimuli. Because stress produces abnormalities in the hypothalamic-pituitary-adrenal axis, the intensity of the two stress conditions were measured by plasmatic corticosteroid (COR) levels: particularly, COR levels doubled in handled rats and increased 15-fold in restrained animals. The SOD activities increased in CTX and decreased in HIP of the handled rats, while in ST a significant decrease in handled animals but an increase in restrained animals occurred. TBARs, GSH, and GSSG levels remained unchanged, while an index of glutathione redox decreased significantly in ST of handled animals and in CTX of restrained ones. Na
+
K
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ATPase activity increased significantly in the HIP and ST of both groups of stressed rats. The stress induced a remarkable increase in PrC levels in all studied cerebral areas. These findings provide evidence to support the idea that stress produces oxidants but that the oxidative damage in stress differs in cerebral areas and could contribute to the degenerative mechanism of aging. 相似文献
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Tool use in left brain damage and Alzheimer's disease: What about function and manipulation knowledge?
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Christophe Jarry François Osiurak Jérémy Besnard Josselin Baumard Mathieu Lesourd Bernard Croisile Frédérique Etcharry‐Bouyx Valérie Chauviré Didier Le Gall 《Journal of Neuropsychology》2016,10(1):154-159
Tool use disorders are usually associated with difficulties in retrieving function and manipulation knowledge. Here, we investigate tool use (Real Tool Use, RTU), function (Functional Association, FA) and manipulation knowledge (Gesture Recognition, GR) in 17 left‐brain‐damaged (LBD) patients and 14 AD patients (Alzheimer disease). LBD group exhibited predicted deficit on RTU but not on FA and GR while AD patients showed deficits on GR and FA with preserved tool use skills. These findings question the role played by function and manipulation knowledge in actual tool use. 相似文献
23.
图形负荷下的字音匹配加工 总被引:1,自引:0,他引:1
本研究采用图形负荷法研究汉字语音匹配加工,实验结果倾向支持两半球均势论,并认为右半球可能具有一定的语音加工能力.有关结论和解释还需进一步论证. 相似文献
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1IntroductionCorrectly identifying other people′s facial ex-pressions of emotions is important to human socialinteraction in all societies.Many studies suggestthat the identification of facial expressions in par-ticular and perceptual processing of emotional infor-mation is carried out mainly by the right hemi-sphere of the brain[1 ̄7].Damage to the righthemisphere generally produces more significant im-pairment in recognition of all facial expressions ofemotion than damage to the left hemisp… 相似文献
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C. A. J. Coady 《The Journal of Ethics》2004,8(1):37-58
This paper begins with a discussion of different definitions of “terrorism” and endorses one version of a tactical definition,
so-called because it treats terrorism as involving the use of a quite specific tactic in the pursuit of political ends, namely,
violent attacks upon the innocent. This contrasts with a political status definition in which “terrorism” is defined as any
form of sub-state political violence against the state. Some consequences of the tactical definition are explored, notably
the fact that (unlike the political status definition) it allows for the possibility of state terrorism against individuals,
sub-state groups and other states. But a major problem for the tactical definition is the account to be given of “the innocent.”
In line with justwar thinking, the idea of “the innocent” is unpacked in terms of the concept of non-combatants and this in
turn is treated as the category of those who are not prosecuting the harm that allows for a legitimate violent response. Problems
with this approach are explored, with particular reference to criticisms made by Gregory Kavka. The recent drive to expand
the class of those who may be legitimately attacked is subjected to scrutiny. Particular attention is paid to the role of
“collective responsibility” and “deserving your government” in these arguments.
This revised version was published online in June 2006 with corrections to the Cover Date. 相似文献
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Normal observers demonstrate a bias to process the left sides of faces during perceptual judgments about identity or emotion. This effect suggests a right cerebral hemisphere processing bias. To test the role of the right hemisphere and the involvement of configural processing underlying this effect, young and older control observers and patients with right hemisphere damage completed two chimeric faces tasks (emotion judgment and face identity matching) with both upright and inverted faces. For control observers, the emotion judgment task elicited a strong left-sided perceptual bias that was reduced in young controls and eliminated in older controls by face inversion. Right hemisphere damage reversed the bias, suggesting the right hemisphere was dominant for this task, but that the left hemisphere could be flexibly recruited when right hemisphere mechanisms are not available or dominant. In contrast, face identity judgments were associated most clearly with a vertical bias favouring the uppermost stimuli that was eliminated by face inversion and right hemisphere lesions. The results suggest these tasks involve different neurocognitive mechanisms. The role of the right hemisphere and ventral cortical stream involvement with configural processes in face processing is discussed. 相似文献
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