Associative learning performance is impaired in zebrafish (Danio rerio) by the NMDA-R antagonist MK-801

The zebrafish is gaining popularity in behavioral neuroscience perhaps because of a promise of efficient large scale mutagenesis and drug screens that could identify a substantial number of yet undiscovered molecular players involved in complex traits. Learning and memory are complex functions of the brain and the analysis of their mechanisms may benefit from such large scale zebrafish screens. One bottleneck in this research is the paucity of appropriate behavioral screening paradigms, which may be due to the relatively uncharacterized nature of the behavior of this species. Here we show that zebrafish exhibit good learning performance in a task adapted from the mammalian literature, a plus maze in which zebrafish are required to associate a neutral visual stimulus with the presence of conspecifics, the rewarding unconditioned stimulus. Furthermore, we show that MK-801, a non-competitive NMDA-R antagonist, impairs memory performance in this maze when administered right after training or just before recall but not when given before training at a dose that does not impair motor function, perception or motivation. These results suggest that the plus maze associative learning paradigm has face and construct validity and that zebrafish may become an appropriate and translationally relevant study species for the analysis of the mechanisms of vertebrate, including mammalian, learning and memory.     

初中生生活事件、心理韧性与学习倦怠的关系

目的:探讨初中生的学习倦怠、生活事件和心理韧性的关系。方法:从济宁市四所初级中学抽取465名初中生,以青少年生活事件量表、青少年心理韧性量表、中学生学习倦怠问卷为研究工具,对初中生进行测查。结果:初中生的学习倦怠水平随年级增长呈逐渐升高趋势;男生的学习倦怠水平显著高于女生;心理韧性作为中介变量,影响到生活事件与学习倦怠之间的关系,中介效应占总效应的比例为42.4%。结论:培养学生的心理韧性可以有助于降低他们的学习倦怠水平。     

Stimulus/response learning in masked congruency priming of faces: Evidence for covert mental classifications?

Reaction times for categorization of a probe face according to its sex or fame were contrasted as a function of whether the category of a preceding, sandwich-masked prime face was congruent or incongruent. Prime awareness was measured by the ability to later categorize the primes, and this was close to chance and typically uncorrelated with priming. When prime faces were never presented as visible probes within a test, priming was not reliable; when prime faces were also seen as probes, priming was only reliable if visible and masked presentation of faces were interleaved (not simply if primes had been visible in a previous session). In the latter case, priming was independent of experimentally induced face–response or face–category contingencies, ruling out any simple form of stimulus–response learning. We conclude that the reliable masked congruency priming reflects bindings between stimuli and multiple, abstract classifications that can be generated both overtly and covertly.     

Getting connected: Both associative and semantic links structure semantic memory for newly learned persons

The present study examined whether semantic memory for newly learned people is structured by visual co-occurrence, shared semantics, or both. Participants were trained with pairs of simultaneously presented (i.e., co-occurring) preexperimentally unfamiliar faces, which either did or did not share additionally provided semantic information (occupation, place of living, etc.). Semantic information could also be shared between faces that did not co-occur. A subsequent priming experiment revealed faster responses for both co-occurrence/no shared semantics and no co-occurrence/shared semantics conditions, than for an unrelated condition. Strikingly, priming was strongest in the co-occurrence/shared semantics condition, suggesting additive effects of these factors. Additional analysis of event-related brain potentials yielded priming in the N400 component only for combined effects of visual co-occurrence and shared semantics, with more positive amplitudes in this than in the unrelated condition. Overall, these findings suggest that both semantic relatedness and visual co-occurrence are important when novel information is integrated into person-related semantic memory.     

“I see what you mean”: Oral deaf individuals benefit from speaker's gesturing

Recent studies in the psychological literature reveal that cospeech gestures facilitate the construction of an articulated mental model of an oral discourse by hearing individuals. In particular, they facilitate correct recollections and discourse-based inferences at the expense of memory for discourse verbatim. Do gestures accompanying an oral discourse facilitate the construction of a discourse model also by oral deaf individuals trained to lip-read? The atypical cognitive functioning of oral deaf individuals leads to this prediction. Experiments 1 and 2, each conducted on 16 oral deaf individuals, used a recollection task and confirmed the prediction. Experiment 3, conducted on 36 oral deaf individuals, confirmed the prediction using a recognition task.     

Spreading the words: A spacing effect in vocabulary learning

The spacing effect refers to the frequently observed finding that distributing learning across time leads to better retention than massing it into one single study session. In the present study, we examined whether the spacing effect generalises to primary school vocabulary learning. To this aim, children from Grade 3 were taught the meaning of 15 new words using a massed procedure and 15 other new words using a spaced procedure. The 15 words in the massed condition were divided into three sets of five words, and each set was taught three times in one of three learning sessions. In the spaced condition, learning was distributed across the three sessions: All 15 words were practised once in each of the three learning sessions. At the retention tests after 1 week and after 5 weeks we observed that the meaning of spaced words was remembered better than the meaning of massed words.     

Digit Span and Articulatory Suppression: A Cross-linguistic Comparison

Information Reduction, a performance-enhancing cognitive strategy which develops with practice, is thought to be consciously and abruptly adopted and then applied consistently. Previous investigations used an Alphabet Verification Task where one observation was that not everyone adopts the strategy, but reasons for this are unclear. We demonstrated Information Reduction in three other tasks, confirming that it is not task-specific. Post-testing questionnaires probed verbally expressible knowledge, to gauge conscious awareness of any strategy. Overall, results indicate considerable variation in Information Reduction usage: Some individuals discovered and used the strategy and could verbally express this, others chose not to use it and some appeared to use it without awareness of doing so. Results also indicate that Information Reduction is not consistently applied, suggesting it is less robust than has been proposed. Our results may be better explained by a theory of practice learning which incorporates both data-driven automaticity and top-down controlled processes.     

Systemic and local administration of estradiol into the prefrontal cortex or hippocampus differentially alters working memory

The influence of estradiol on learning and memory is dependent on a number of factors. The effects of physiological levels of estradiol on the acquisition of a spatial working memory task mediated by the prefrontal cortex (PFC) and the hippocampus were examined in Experiment 1. Ovariectomized Long-Evans rats received daily injections of estradiol or vehicle were tested on the win-shift version of the radial arm maze. A high dose of estradiol benzoate (5 microg) enhanced acquisition of the task, whereas a low dose of estradiol (0.3 microg) increased the number of errors committed over 17 days of testing. Experiment 2 was conducted to examine site-specific influences of estradiol on spatial working memory in well-trained rats. Saline and estradiol cyclodextrin (0.1 and 0.9 microg) were infused into the prelimbic region of the PFC or dorsal hippocampus 40 min prior to testing on the win-shift task. Infusions of estradiol into both brain areas attenuated saline-infusion disruptions in working memory. Specifically, the higher dose of estradiol facilitated working memory when infused into the PFC, whereas the lower dose of estradiol facilitated performance when infused into the dorsal hippocampus. Moreover, working memory was significantly impaired 24 h after infusions of estradiol into the dorsal hippocampus but not the PFC. These data provide further evidence for the notion that estradiol can dose-dependently alter memory processes and suggest that facilitation or disruptions of working memory by estradiol are site- and time-specific.     

Inhibition and shifting in children with learning deficits in arithmetic and reading

The executive functions of inhibition and shifting were studied in arithmetic-disabled children, reading-disabled children, reading plus arithmetic-disabled children, and controls (N = 74). Measures involved the rapid naming of objects, digits, letters, or quantities with or without additional task requirements that reflected inhibition or shifting. Also, the Making Trails task, reflecting shifting, was administered. For tasks without executive demands, arithmetic-disabled children were slower in the naming of digits and quantities, whereas reading-disabled children were slower in the naming of digits and letters. For the executive tasks, arithmetic-disabled children as well as reading plus arithmetic-disabled children were impaired on the Making Trails task and on an object naming task that required both inhibition and shifting. Reading-disabled children exhibited no problems in executive functioning. Furthermore, it was shown that reading plus arithmetic-disabled children experienced the combination of problems that characterize children with a single learning deficit.     

Learning and transfer from a simple dynamic system

The amount of learning gained from being assisted in completing the task of bringing a predator-prey system into equilibrium by controlling the predator population was investigated. Learning was explored both by post-task questioning and by testing for transfer to another predator-prey task. Participants were 28 undergraduate psychology students, all female. They were randomly and evenly split into an experiment group that was subjected to a learning session with the first task before being tested in the second task, and a control group that only performed the second task. What was most needed in the first task was help in sticking to analytically derived conclusions by resisting "common sense" responses. There was a significant transfer effect on performance to the second task, stemming from learning shown by half the participants in the experiment group. The other half showed hardly any learning. Learning in about half the subjects has proven a stable finding.