“荀”、“孔”危机与中国近世精神纬度——从一个侧面看二十世纪初新文化运动的必然

清末政治的内忧外患及文化思想上西学的冲击,动摇了中国传统的道德礼教与伦理纲常。受过西方思潮与科学进步影响的近代知识分子清醒地认识到,中国的危难并非晚清独遇的社会政治危机,而是千古未有的文化危机。鼓吹维新,废除礼教,开启民智,振兴中国,成为维新君子的神圣职责。反礼教、排荀儒成为反封建专制首先揭橥的精神旗纛。此后,排荀思潮上升为反孔,直接引发了以“打倒孔家店”为中心的五四新文化运动,宣告了两千年封建专制制度的解体,同时建构了以国家、平等、民主、自由为中心的中国近现代精神。     

Typologies of Alcohol Dependence. From Jellinek to Genetics and Beyond

The goal of typology research is to identify subtypes of alcohol dependent (AD) patients sharing fundamental characteristics and try to match each subtype, with the most precise treatment strategy. This review provides a comprehensive history of the literature on alcohol dependent subtypes starting from the earliest attempt made by Jellinek. The binary models identified most closely with Cloninger and Babor as well as the successively more complex classifications are discussed. Typology classification potentially useful in guiding the treatment of AD patients, especially in the case of the serotonergic medications. Contrasting data suggests that other factors could influence the response to a medication and/or that more complex typologies should be identified. In summary, typology models may assist in the ascertainment criteria for clinical trials performed in behavioral and pharmacotherapeutic interventions. Greater emphasis, however, must be made to more clearly delineate this field of research, while moving toward more standardized typologies.     

INTRODUCTION: RETHINKING PHILOSOPHICAL PRESUMPTIONS IN LIGHT OF COGNITIVE DISABILITY

Abstract: This Introduction to the collection of essays surveys the philosophical literature to date with respect to five central questions: justice, care, agency, metaphilosophical issues regarding the language and representation of cognitive disability, and personhood. These themes are discussed in relation to three specific conditions: intellectual and developmental disabilities, Alzheimer's disease, and autism, though the issues raised are relevant to a broad range of cognitive disabilities. The Introduction offers a brief historical overview of the treatment cognitive disability has received from philosophers, and explains the specific challenges that cognitive disability poses to philosophy. In briefly summarizing the essays in the collection, it highlights the distinctive contributions the collection makes to ethics, political philosophy, bioethics, and the philosophy of disability. We hope that the richness of the topics explored by these essays will be a spur to further investigation.     

Development of adolescence‐limited,late‐onset,and persistent offenders from age 8 to age 48

This article investigates the life success at ages 32 and 48 of four categories of males: nonoffenders, adolescence‐limited offenders (convicted only at ages 10–20), late‐onset offenders (convicted only at ages 21–50), and persistent offenders (convicted at both ages 10–20 and 21–50). In the Cambridge Study in Delinquent Development, 411 South London males have been followed up from age 8 to 48 in repeated personal interviews. There was considerable continuity in offending over time. Persistent offenders had the longest criminal careers (averaging 18.4 years), and most of them had convictions for violence. Persistent offenders were leading the most unsuccessful lives at ages 32 and 48, although all categories of males became more successful with age. By age 48, the life success of adolescence‐limited offenders was similar to that of nonoffenders. The most important risk factors at ages 8–18 that predicted which offenders would persist after age 21 were heavy drinking at age 18, hyperactivity at ages 12–14, and low popularity and harsh discipline at ages 8–10. The most important risk factors that predicted which nonoffenders would onset after age 21 were poor housing and low nonverbal IQ at ages 8–10, high neuroticism at age 16, and anti‐establishment attitudes and motoring convictions at age 18. It was suggested that nervousness and neuroticism may have protected children at risk from offending in adolescence and the teenage years. Aggr. Behav. 35:150–163, 2009. © 2009 Wiley‐Liss, Inc.     

Is auditory awareness negativity confounded by performance?

Research suggests that the electrophysiological correlates of consciousness are similar in hearing as in vision: the auditory awareness negativity (AAN) and the late positivity (LP). However, from a recently proposed signal-detection perspective, these correlates may be confounded by performance, as the strength of the internal responses differs between aware and unaware trials. Here, we tried to apply this signal-detection approach to correct for performance in an auditory discrimination and detection task (N = 28). A large proportion of subjects had to be excluded because even a small response bias distorted the correction. For the remaining subjects, the correction mainly increased noise in the measurement. Furthermore, the signal-detection approach is theoretically problematic because it may isolate post-perceptual processes and eliminate awareness-related activity. Therefore, we conclude that AAN and LP are not confounded by performance and that the contrastive analysis identifies both as correlates of awareness.     

ERP and MEG correlates of visual consciousness: The second decade

The first decade of event-related potential (ERP) research had established that the most consistent correlates of the onset of visual consciousness are the early visual awareness negativity (VAN), a posterior negative component in the N2 time range, and the late positivity (LP), an anterior positive component in the P3 time range. Two earlier extensive reviews ten years ago had concluded that VAN is the earliest and most reliable correlate of visual phenomenal consciousness, whereas LP probably reflects later processes associated with reflective/access consciousness. This article provides an update to those earlier reviews. ERP and MEG studies that have appeared since 2010 and directly compared ERPs between aware and unaware conditions are reviewed, and important new developments in the field are discussed. The result corroborates VAN as the earliest and most consistent signature of visual phenomenal consciousness, and casts further doubt on LP as an ERP correlate of phenomenal consciousness.     

Neuropsychological differentiation of progressive aphasic disorders

The differentiation of subtypes of primary progressive aphasia (PPA) remains challenging. We aimed to identify optimum neuropsychological measures for characterizing PPA, to examine the relationship between behavioural change and subtypes of PPA and to determine whether characteristic profiles of language, working memory, and behavioural changes occur in PPA. Forty-seven patients with PPA and multi-domain Alzheimer's disease (AD) together with 19 age-matched controls underwent a large battery of working memory and language tests. We found that simple tasks of sentence ordering, narrative production, and buccofacial praxis were particularly useful in differentiating non-fluent/agrammatic variant PPA (nfvPPA) from other PPA subtypes, whereas a test of single word comprehension was useful in detecting semantic dementia (SD). No individual tests were discriminating for logopenic variant PPA (lvPPA) relative to nfvPPA. LvPPA and multidomain AD exhibited similar language profiles. A principal components analysis revealed that characteristic PPA profiles extended beyond the realms of language, in particular, the presence of apraxia in nfvPPA, behavioural changes in SD, and working memory deficits in lvPPA. These findings suggest that not all tests are equally discriminatory for PPA and highlight the importance of a test profile in differentiating PPA. These results also support the view that lvPPA is a focal form of AD and emphasize the difficulties classifying lvPPA.     

Mental time travel to the future might be reduced in sleep

We present a quantitative study of mental time travel to the future in sleep. Three independent, blind judges analysed a total of 563 physiology-monitored mentation reports from sleep onset, REM sleep, non-REM sleep, and waking. The linguistic tool for the mentation report analysis is based on established grammatical and cognitive-semantic theories and has been validated in previous studies. Our data indicate that REM and non-REM sleep must be characterized by a reduction in mental time travel to the future, which would support earlier physiological evidence at the level of brain function.