Medicine and pharmacy — facts and myths about the development of an innovative pharmaceutical industry in Poland

Innovation is fundamental to the pharmaceutical industry and a key to improvements in healthcare. Its effectiveness depends on huge, constant investments in research. This innovative industry directly affects the course of studies in healthcare and medicine. Its efforts translate directly into the length and quality of our lives. For several years now, the progress underway in pharmaceutical industry has produced measurable benefits. Doctors have new pharmaceuticals at their disposal, including many types of antibiotics and anti-viral drugs, vaccines and a wide range of drugs which save lives or make them more comfortable. In the near future, ever more efficient cures for neoplastic, rheumatic, neurological, psychic, metabolic, circulatory or respiratory diseases can be expected. Innovation is necessary. The human population is ageing, and the task of an innovative pharmaceutical industry is to keep it in a good condition. The use of innovative drugs can translate directly into lowering the costs of illness. A continuous reduction in spending on healthcare has been observed. The costs of inventing an innovative drug are enormous though (US$ 800 million), and studies on a new drug last between 10 and 13 years. An essential element in recovering the incurred costs and ensuring funds needed for new research is protection by patent. Innovative pharmaceutical companies in Poland are committed to increasing the competitiveness and sustaining the development of not only the market, but also the entire pharmaceutical sector. It is a group of companies of crucial importance to the Polish healthcare system, as it influences improvement in the quality of medical services. Through their investments and spending on research and development, innovative companies accelerate economic growth. In Poland, the innovative pharmaceutical industry is represented by the Association of Pharmaceutical Companies Representatives in Poland (SPFFwP). An earlier version of this paper was presented at an international conference, “The Ethics of Intellectual Property Rights and Patents,” held in Warsaw, Poland on 23–24 April, 2004.     

The Child Behavior Checklist for Group Care Workers: A Study Regarding the Factor Structure

In this study we examined the factor structure of the Child Behavior Checklist (CBCL) filled out by group care workers. Group care workers' judgements were collected on 846 children and adolescents treated in various residential settings in The Netherlands. Using confirmatory factor analysis, we were able to show that the original CBCL factor model based on parental judgments of child behavior also fits for the judgments of group care workers. This means that the well known 8 narrow-band syndromes (Withdrawn, Somatic Complaints, etc.) as well as the 2 broad-band syndromes (Internalizing and Externalizing) can be used to interpret the CBCL scores of group care workers. This confirmation of the CBCL factor structure is a first step to add a group care worker version to the CBCL family. However, as a second step, normative data need to be gathered to further enhance the use of the CBCL for group care workers.     

Suppression of scientific research: Bahramdipity and Nulltiple scientific discoveries

The fairy tale The Three Princes of Serendip can be taken to be allegorical of not only chance discovery (serendipity) but of other aspects of scientific discovery as well. Just as Horace Walpole coined serendipity, so can the term bahramdipity be derived from the tale and defined as the cruel suppression of a serendipitous discovery. Suppressed, unpublished discoveries are designated nulltiples. Several examples are presented to make the case that bahramdipity is an existent aspect of scientific discovery. Other examples of non-ideal scientific research and discovery are provided in order to contrast and clarify the meaning and use of bahramdipity. Additional allegories of scientific discovery are taken from the tale and a hope for the strengthening of scientific integrity is expressed.     

转型期初中生心理健康与父母养育方式的研究

本研究采用《心理健康诊断量表》和《父母养育方式问卷》对196名初中生进行测量,探讨初中生心理健康与父母养育方式的影响因素及其相互之间的关系。结果表明,初中生的心理健康问题的检出率依次是自责倾向、恐怖倾向、冲动倾向和对人焦虑;性别因素只在心理健康的学习焦虑、养育方式上的父亲的惩罚、严厉、母亲的过干涉、过保护、父母的拒绝、否认等因素上表现出了显著差异;独生子女与非独生子女子女比较,在恐怖倾向以及惩罚、严厉的养育方式上存在显著差异;父母的文化程度、职业状况、离异、下岗等因素,只有母亲的职业状况因素对心理健康构成了影响;父母消极的教养方式将使学生的焦虑增加,母亲积极的教养方式将使学生的焦虑减少。     

Mentors, advisors and supervisors: Their role in teaching responsible research conduct

Although the terms mentor and thesis advisor (or research supervisor) are often used interchangeably, the responsibilities associated with these roles are distinct, even when they overlap. Neither are role models necessarily mentors, though mentors are role models: good examples are necessary but not sufficient. Mentorship is both a personal and a professional relationship. It has the potential for raising a number of ethical concerns, including issues of accuracy and reliability of the information conveyed, access, stereotyping and tracking of advisees, and the abuse of power. Nevertheless, mentors can be critically important for professional success and are one of a number of elements that affect the responsible conduct of research. In addition, the community as a whole has a responsibility to mentor junior members. An earlier version of this paper was presented at a conference sponsored by the National Science Foundation on Mentoring and Research Values: Students as Vital Human Resources, Chicago, USA, March 1995.     

Vice and Reason

Aristotle's account of vice presents a puzzle: (1) Viciouspeople must be guided by reason, since they act on decision(prohairesis), not on their non-rational desires. (2) And yet theycannot be guided by reason, since they are said to pay attention totheir non-rational part and not to live in accordance with reason. Wecan understand the conception of vice the reconciles these two claims,once we examine Aristotle's account of (a) the pursuit of the fine andof the expedient; (b) the connexion between vice and the pursuit ofpleasure; (c) the particular kind of regret to which the vicious personis subject.     

Philosophy and language learning

In this paper, I explore different ways of picturing language learning in philosophy, all of them inspired by Wittgenstein and all of them concerned about scepticism of meaning. I start by outlining the two pictures of children and language learning that emerge from Kripke’s famous reading of Wittgenstein. Next, I explore how social-pragmatic readings, represented by Meredith Williams, attempt to answer the sceptical anxieties. Finally, drawing somewhat on Stanley Cavell, I try to resolve these issues by investigating what characteristically happens to our view of language learning when we do philosophy. The focus throughout is on the relation between the individual (the learning child) and the community (usually represented by the parents), and how that relation is deformed when we operate with a certain philosophical notion of ground.     

Language structure: psychological and social constraints

In this article we discuss the notion of a linguistic universal, and possible sources of such invariant properties of natural languages. In the first part, we explore the conceptual issues that arise. In the second part of the paper, we focus on the explanatory potential of horizontal evolution. We particularly focus on two case studies, concerning Zipf’s Law and universal properties of color terms, respectively. We show how computer simulations can be employed to study the large scale, emergent, consequences of psychologically and psychologically motivated assumptions about the working of horizontal language transmission.     

The representation of discourse in the two hemispheres: an individual differences investigation

Two experiments were conducted to investigate discourse representation in the two cerebral hemispheres as a function of reading skill. We used a lateralized visual-field procedure to compare left hemisphere (LH) and right hemisphere (RH) sensitivity to different discourse relations in readers with varying skill levels. In Experiment 1, we investigated two levels of discourse representation in memory: (a) the propositional representation and (b) the discourse model. We found that all readers were sensitive to propositional relations in the LH. In contrast, sensitivity to propositional relations in the RH increased as a function of reading skill. In addition, reading skill was positively related to topic relations in the LH, whereas it was negatively in the RH. In Experiment 2, we investigated propositional relations of different distances and again found that all readers were sensitive to propositional relations in the LH, whereas sensitivity to propositional relations in the RH was negatively related to reading skill. In general, reading skill appears to be associated with left-lateralized discourse representations.     

The relationship between reduplicated babble onset and laterality biases in infant rhythmic arm movements

This study examined changes in rhythmic arm shaking and laterality biases in infants observed longitudinally at three points: just prior to, at, and just following reduplicated babble onset. Infants (ranging in age from 4 to 9 months at babble onset) were videotaped at home as they played with two visually identical audible and silent rattles presented at midline for 1.5 min each. Rate of rattle shaking increased sharply from the pre-babble to the babble onset session; but there was no indication that this increase was specific to the right arm. This finding suggests that the link between babble onset and increased rhythmic arm activity may not be the product of language-specific mechanisms, but is rather part of a broader developmental process that is also perceptual and motor.