Social cognition and real-life functioning in patient samples with 22q11.2 deletion syndrome with or without psychosis,compared to a large sample of patients with schizophrenia only and healthy controls

Patients with the 22q11.2 deletion syndrome (DS) show an increased risk of developing a psychotic illness lifetime. 22q11.2DS may represent a reliable model for studying the neurobiological underpinnings of schizophrenia. The study of social inference abilities in a genetic condition at high risk for psychosis, like 22q11.2DS, may shed light on the relationships between neurocognitive processes and patients' daily general functioning. The study sample consisted of 1736 participants, divided into four groups: 22q11.2DS patients with diagnosis of psychotic disorder (DEL SCZ, N = 20); 22q11.2DS subjects with no diagnosis of psychosis (DEL, N = 43); patients diagnosed with schizophrenia without 22q11.2DS (SCZ, N = 893); and healthy controls (HC, N = 780). Social cognition was assessed through The Awareness of Social Inference Test (TASIT) and general functioning through the Specific Levels of Functioning (SLoF) scale. We analysed data through regression analysis. The SCZ and DEL groups had similar levels of global functioning; they both had significantly lower SLoF Total scores than HC (p < .001); the DEL SCZ group showed significantly lower scores compared to the other groups (SCZ, p = .004; DEL, p = .003; HC, p < .001). A significant deficit in social cognition was observed in the three clinical groups. In the DEL SCZ and SCZ groups, TASIT scores significantly predicted global functioning (p < .05). Our findings of social cognition deficit in psychosis-prone patients point to the possible future adoption of rehabilitation programmes, like Social Skills Training and Cognitive Remediation, during premorbid stages of psychosis.     

Utility of extension of functional equations—when possible

Jean-Claude Falmagne observed in 1981 [On a recurrent misuse of classical functional equation result. Journal of Mathematical Psychology, 23, 190-193] that, even under regularity assumptions, not all solutions of the functional equation k(s+t)=k(s)+k(t), important in many fields, also in the theory of choice, are of the form k(s)=Cs. This is certainly so when the domain of the equation (the set of (s,t) for which the equation is satisfied) is finite. We mention an example showing that this can happen even on some infinite, open, connected sets (open regions). The more general equations k(s+t)=?(s)+n(t) and k(s+t)=m(s)n(t), called Pexider equations, have been completely solved on R². In case they are assumed valid only on an open region, they have been extended to R² and solved that way (the latter if k is not constant). In this paper their common generalization

k(s+t)=?(s)+m(s)n(t)     

Altruistic values in children’s spirituality: a study of children’s responses to the terror attacks in Oslo and on Utøya and issues of education

In reactions to the terror attacks in Oslo and on Utøya on July 22, 2011, belief in an open society, hope and altruism played an important part. This has led to research on the role of such values in Norwegian democracy. The present study explores messages given by children right after the event, using an approach based on Mikhail Bakhtin’s philosophy of dialogue. Several issues of educational significance are discussed: the meaning of ritual in children’s thinking, coping with offending, death, and understanding children’s spiritual and religious thinking when confronted with a critical event. It is argued that hope and altruism seem to be natural parts of children’s spirituality, but these values are not self-evident in a society. This is a challenge to education.     

Selective and sustained attention in children with spina bifida myelomeningocele

This study examined memory functioning in children and adolescents with 22q11.2 Deletion Syndrome (DS; velocardiofacial syndrome). An overall verbal better than nonverbal memory pattern was evident on the Test of Memory and Learning (TOMAL), with children with 22q11.2 DS performing significantly below their siblings and children with low average IQ but similar to children with autism on facial memory. Children with 22q11 DS also performed significantly below their siblings on tests of verbal working memory. Children with autism performed significantly poorer than the siblings of children with 22q11.2 DS only on their recall of stories. Delayed recall was significantly poorer in children with 22q11.2 DS and children with autism, compared to sibling controls. Although there were no significant group differences on tests of multiple trial verbal or visual learning, a relative weakness was noted with multiple trial visual learning in children with 22q11.2 DS and their siblings, suggesting that an alternative or interactive factor other than the deletion may account for the relatively better verbal compared to nonverbal memory abilities. Deficits in facial memory in children with both 22q11.2 DS and autism suggest disruptions in ventral temporal pathways such as between fusiform gyrus and parahippocampal/hippocampal regions whereas deficits in verbal working memory in children with 22q11.2 DS implicates dorsolateral prefrontal regions, both intimating aberrant white matter pathways.     

Attention Deficits in Children with &lt; 750 gm Birth Weight

Although attention deficit disorders are frequently diagnosed in low birth-weight children, it is not clear if attention problems are apparent in neuropsychological testing. The present study examined the performances of a regional sample of 68 children with birth weights &lt;750 gm on several psychometric measures of attention given at early school age. Matched groups of 65 children with birth weights between 750–1499 gm and 61 term controls were also assessed. The group &lt;750 gm performed more poorly on one attention test than did either comparison group, even when overall cognitive ability was taken into account. Performances on the attention tests were also related to academic skills and ratings of behavior. Findings confirm the hypothesis that children with birth weights &lt;750 gm have specific attentional weaknesses and support the validity of attention tests as predictors of learning and behavior problems.     

States on Pseudo MV-Algebras

Pseudo MV-algebras are a non-commutative extension of MV-algebras introduced recently by Georgescu and Iorgulescu. We introduce states (finitely additive probability measures) on pseudo MV-algebras. We show that extremal states correspond to normal maximal ideals. We give an example in that, in contrast to classical MV-algebras introduced by Chang, states can fail on pseudo MV-algebras. We prove that representable and normal-valued pseudo MV-algebras admit at least one state.     

Executive functioning and its relation to ASD and ADHD symptomatology in 22q11.2 deletion syndrome*

Children with 22q11.2 deletion syndrome (22q11DS; velo-cardio-facial-syndrome) are at risk for the developmental disorders, attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). In this study, the relation between executive functioning (EF) and the severity of ADHD and ASD symptoms is examined, since EF is known to be important in relation to emotional and behavioral problems. The participants consist of 58 children (38 females) with a mean age of 13.5 years (SD 2.6). Standardized assessment was used to evaluate the severity of ASD and ADHD symptomatology. The major aspects of EF, i.e., cognitive flexibility, inhibition, sustained attention, distractibility, working memory and reaction speed, were evaluated. The profile of EF in 22q11DS was found to be characterized by weaker performance compared to the norms on all subdomains of EF. Poor cognitive flexibility and inhibition, as well as high distractibility, were found to be related to more severe ASD symptoms, while poor quality of sustained attention and high distractibility were found to be related to more severe ADHD symptoms. It is concluded that children with 22q11DS experience impairments in EF, and that the degree of impairment on specific EF subdomains is related to the severity of ASD and/or ADHD symptomatology. These results may help in defining the mediating role of neurocognitive dysfunctions in the development of social and behavioral problems in 22q11DS.     

22q11.2 Deletion Syndrome: Genetics,Neuroanatomy and Cognitive/Behavioral Features Keywords

This paper presents a conceptual review of the genetic underpinnings of 22q11.2 Deletion Syndrome. The neuroanatomical, neuropsychological, behavioral, and psychiatric phenotype associated with 22q11.2 Deletion Syndrome is also explored, including variables that are thought to affect symptom expression. The history of the deletion syndrome is described, and future directions for continued research are discussed.