心理行为干预对乳腺癌患者情绪反应及免疫功能的影响

按随机和匹配原则,将40名乳腺癌放疗患者分入干预组和对照组。对干预组患者进行为期4周的心理行为干预,对照组仅接受相应的医药治疗。以肿瘤病人情绪适应问卷(MAC)和免疫测试法研究患者干预前后的情绪反应和免疫功能,探讨心理行为干预对乳腺癌患者情绪反应和免疫功能的影响。结果发现,心理行为干预有利于提高患者NK细胞活性(NKCA);并有助于维持放疗期间患者的白细胞水平。     

The transfer of respondent eliciting and extinction functions through stimulus equivalence classes

Two studies investigated the transfer of respondent elicitation through equivalence classes. In Experiment 1, match-to-sample procedures were used to teach 8 subjects two four-member equivalence classes. One member of one class was then paired with electric shock, and one member of the other class was presented without shock. All remaining stimuli were then presented. Using skin conductance as the measure of conditioning, transfer of conditioning was demonstrated in 6 of the 8 subjects. In Experiment 2, similar procedures were used to replicate the results of Experiment 1 and investigate the transfer of extinction. Following equivalence training and conditioning to all members of one class, one member was then presented in extinction. When the remaining stimuli from this class were then presented, they failed to elicit skin conductance. In the final phase of the experiment, the stimulus that was previously presented in extinction was reconditioned. Test trials with other members of the class revealed that they regained elicitation function. These results demonstrate that both respondent elicitation and extinction can transfer through stimulus classes. The clinical and applied significance of the results is discussed.     

The Relations Between Patterning,Executive Function,and Mathematics

Patterning, or the ability to understand patterns, is a skill commonly taught to young children as part of school mathematics curricula. It seems likely that some aspects of executive function, such as cognitive flexibility, inhibition, and working memory, may be expressed in the patterning abilities of children. The primary objective of the present study was to examine the relationship between patterning and executive functioning for first grade children. In addition, the relations between patterning, executive functioning, mathematics, and reading were examined. The results showed that patterning was significantly related to cognitive flexibility and working memory, but not to inhibition. Patterning, cognitive flexibility, and working memory were significantly related to mathematical skills. Only patterning and working memory were significantly related to reading. Regression analyses and structural equation modeling both showed that patterning had effects on both reading and mathematics measures, and that the effects of cognitive flexibility were entirely mediated by patterning. Working memory had independent effects on reading and mathematics, and also effects moderated by patterning. In sum, these findings suggest that cognitive flexibility and working memory are related to patterning and express their effects on reading and mathematics in whole or in part through patterning.     

Neuropsychological deficits in preschool as predictors of ADHD symptoms and academic achievement in late adolescence

High levels of ADHD symptoms are related to severe negative outcomes, which underscore the importance of identifying early markers of these behavior problems. The main aim of the present study was therefore to investigate whether neuropsychological deficits in preschool are related to later ADHD symptoms and academic achievement, over and above the influence of early ADHD symptom levels. The present study is unique because it includes a broader range of predictors compared to previous studies and the participants are followed over time for as long as 13 years (i.e., ages 5–18 years). Preschool data included measures of executive functioning and reaction time variability as well as emotional reactivity and emotion regulation of both positive and negative emotions. When controlling for early ADHD symptom levels, working memory, reaction time variability, and regulation of happiness/exuberance were significantly related to inattention whereas regulation of happiness/exuberance and anger reactivity were significantly related to hyperactivity/impulsivity. Furthermore, working memory and reaction time variability in preschool were significantly related to academic achievement in late adolescence beyond the influence of early ADHD symptoms. These findings could suggest that it is possible to screen for early neuropsychological deficits and thereby identify children who are at risk of negative outcomes. Furthermore, our results suggest that interventions need to look beyond executive functioning deficits in ADHD and also target the role of emotional functioning and reaction time variability. The importance of including both the positive and negative aspects of emotional functioning and distinguishing between emotion regulation and emotional reactivity was also demonstrated.     

Cognitive and behavioral rating measures of executive function as predictors of academic outcomes in children

Interrelations of two measurement methods (cognitive versus behavioral ratings) for executive function (EF) were examined and related to reading comprehension and math calculations in fourth and fifth grade students (n = 93) in the context of a diverse urban student population. Relations among measures within four EF processes (working memory, planning, inhibition and shifting) were modest; relations to academics were stronger. EF measures contributed to both academic outcomes even in the context of relevant covariates (age, language and educational program). Working memory was particularly important for reading comprehension across measurement type. Cognitive measures from all EF processes, particularly inhibition and planning, and behavioral ratings of working memory were important for math.     

Neurophysiological marker of inhibition distinguishes language groups on a non-linguistic executive function test

Successful interaction with the environment depends on flexible behaviors which require shifting attention, inhibiting primed responses, ignoring distracting information, and withholding motor responses. These abilities, termed executive function (EF), are believed to be mediated by inhibitory processes in the frontal lobes. Superior performance on EF tests (i.e., faster reaction times (RT), and fewer errors) has been shown in bilinguals compared to monolingual speakers. However, findings are inconsistent, and no study has directly linked this bilingual advantage to frontal lobe inhibitory processes. To clarify this uncertainty, we concomitantly tested neural inhibitory processes and behavioral responses on an EF test in bilinguals and monolinguals. Specifically, we compared English monolinguals (N = 15) to Spanish/English bilinguals (N = 13) on event-related brain potentials (ERP) during a non-linguistic, auditory Go/NoGo task, a task linked to non-motor, cognitive inhibition in monolinguals. Participants responded with a button press on trials in which target tone-pairs (Go trials) were presented and withheld their responses on non-target trials (NoGo trials). Results revealed significantly greater inhibition (i.e., greater mean N2 amplitude) in bilinguals compared to monolinguals during NoGo trials even though both groups performed the task equally well (i.e., withheld a motor response). On Go trials where participants pressed a response button, neither ERPs nor RT distinguished the groups. Additionally, scores on a second language proficiency test (i.e., English in our bilingual group) were positively correlated with N2 amplitude. These findings are the first to directly link this bilingual advantage to a neural correlate of inhibition and to reveal that inhibition in bilinguals is moderated by second language proficiency. Results are discussed in the context of plasticity, and we propose that evaluating bilinguals at varying levels of second-language proficiency may serve as a model of human neuroplasticity.     

The impact of working memory load on task execution and online plan adjustment during multitasking in a virtual environment

Three experiments investigated the impact of working memory load on online plan adjustment during a test of multitasking in young, nonexpert, adult participants. Multitasking was assessed using the Edinburgh Virtual Errands Test (EVET). Participants were asked to memorize either good or poor plans for performing multiple errands and were assessed both on task completion and on the extent to which they modified their plans during EVET performance. EVET was performed twice, with and without a secondary task loading a component of working memory. In Experiment 1, articulatory suppression was used to load the phonological loop. In Experiment 2, oral random generation was used to load executive functions. In Experiment 3, spatial working memory was loaded with an auditory spatial localization task. EVET performance for both good- and poor-planning groups was disrupted by random generation and sound localization, but not by articulatory suppression. Additionally, people given a poor plan were able to overcome this initial disadvantage by modifying their plans online. It was concluded that, in addition to executive functions, multiple errands performance draws heavily on spatial, but not verbal, working memory resources but can be successfully completed on the basis of modifying plans online, despite a secondary task load.     

论执行功能及其发展研究

执行功能(executive function,EF)是一个还没有明确定义的概念,但又是一个重要的概念,通常是指个体对思想和行动进行有意识控制的心理过程。目前的主要观点包括神经心理学观点、抑制控制理论、高级认知能力理论(包括工作记忆理论、抑制及工作记忆理论)和认知复杂性和控制理论。主要的研究任务类型包括卡片分类任务、延迟反应任务、基于Stroop任务的冲突反应模式任务、心理理论任务、问题解决任务、“热”执行功能任务等。未来的研究应着重弄清执行功能的本质,结合认知神经科学阐明其与脑神经结构和功能的关系,并从区分“冷”执行功能和“热”执行功能的角度,探讨以情感激活为特点的“热认知”在执行功能中的作用。     

执行功能研究方法评述

虽然对执行功能的研究长期以来都是从神经心理学角度出发的,但现在发展心理学领域中也出现了大量的研究,其研究方法也层出不穷。该文从发展心理学角度分析了研究儿童冷执行功能和热执行功能的常用方法,包括搜寻任务、规则运用任务、优势规则抑制任务、矛盾冲突任务、问题解决任务、图片工作记忆任务、心理理论任务、延迟满足任务、儿童博弈任务和反向择物。通过对这些方法的分析,作者发现,执行功能的概念已逐步扩展到包容整个认知过程,而已有的关于执行功能的观点都只强调了其中某一个或几个方面,还没有一种观点能够将上述方法所研究的执行功能概括完整。执行功能的本质还远远不能清晰地展示在我们面前。     

Local influence analysis of nonlinear structural equation models

By regarding the latent random vectors as hypothetical missing data and based on the conditional expectation of the complete-data log-likelihood function in the EM algorithm, we investigate assessment of local influence of various perturbation schemes in a nonlinear structural equation model. The basic building blocks of local influence analysis are computed via observations of the latent variables generated by the Metropolis-Hastings algorithm, while the diagnostic measures are obtained via the conformal normal curvature. Seven perturbation schemes, including some perturbation schemes on latent vectors, are investigated. The proposed procedure is illustrated by a simulation study and a real example. Acknowledgment: This research is fully supported by a grant (CUHK 4243/02H) from the Research Grant Council of the Hong Kong Special Administration Region. The authors are indebted to ICPSR and the relevant funding agency for allowing use of their data, and to the Editor and reviewers for their valuable comments for improving the paper.