中国人群脂肪肝主要影响因素的荟萃分析

为系统评价中国居民脂肪肝发病的主要危险因素,检索文献数据库,收集国内1997年～2008年有关脂肪肝发病危险因素的16篇文献,利用Meta分析方法,进行综合统计分析,累计病例7200例,对照11884例。结果超重（23≤BMI〈25）、肥胖（BMI≥25）、过量饮酒、吸烟、高脂饮食、食用蔬菜、饮绿茶、爱好运动、运动少、高脂血症、高HDL—Ch、低HDL-Ch、高血压、高血糖、高血总胆固醇（≥6．5mmol／L）及糖尿病合并0R值（95％CI）分别为1．68（0．68～3．90）、5．01（3．23～7．76）、3．52（1．52～8．15）、1．18（1．01～1．37）、2．82（1．50～5．31）、0．45（0．37～0．55）、0．52（0．43～0．64）、0．32（0．14～O．74）、3．49（1．26～9．65）、4．91（2．69～8．96）、0．31（0．17～0．57）、2．14（1．50～3．03）、2．19（1．43～3．35）、2．75（1．66～4．58）、2．96（0．26～32．98）、2．29（1．30～4．01）。结论为目前影响中国人群脂肪肝发生的危险因素依次为肥胖、高脂血症、饮酒、运动少、高脂饮食、高血糖、糖尿病、高血压、低HDL—Ch和吸烟;保护因素为饮用绿茶,食用蔬菜,以及高HDL—ch;尚不能确定与中国人脂肪肝发生的相关性因素为超重和高血胆固醇。     

牙科焦虑症患者心理干预的疗效分析

为了探讨心理诱导对牙科焦虑（dental anxiety,DA）患者治疗的影响,采用焦虑自评量表及汉密顿焦虑量表对门诊就诊患者进行焦虑调查,筛选出伴焦虑者82例,随机分为两组,分别进行心理干预治疗和一般治疗,并对数据进行统计分析。结果显示,心理诱导指导组与时照组相比较焦虑水平明显降低,患者无论在完成第一次治疗还是复诊情况均优于对照组（P〈0．01）。提示心理干预对DA患者治疗有显著效果。     

疾病的哲学思考——坦然和平静地对待疾病

面对人类无法改变与疾病共存的命运,本文从健康与疾病的关系、疾病的原因、疾病的话语、对待疾病的态度和利用疾病的契机五个方面来进行哲学追问和反思。以期使我们通过倾听身体的语言,来坦然、自然和平静地对待疾病;利用疾病的契机,获得身心的成长,使人类的生命在亘古的绵延中永远充盈着盎然的生机。     

农村与城镇终末期肾病患者临床状况比较分析

时比分析农村与城镇终末期肾病患者的临床状况,旨在了解新农合政策带给农村终末期肾病患者的益处及今后还需完善和努力之处.对广西壮族自治区人民医院血液净化治疗中心2007年新增的238例终末期肾病患者按农村与城镇进行分组对比分析.96例农村患者,88例选择血液透析,8例放弃治疗;142例城镇患者,23例选择腹膜透析,108例血液透析,11例放弃.无论是城镇还是农村患者慢性肾炎为主要的原发病、都存在透析过晚、并发症发生率高、急诊透析率高的现象.与城镇组相比,农村组患者平均年龄、肾痛知晓率、残余肾功能、血红蛋白、二氧化碳结合力、尿素清除指数低于城镇组(P<0.05);梗阻性肾病发病率、并发症发生率、急诊透析率、死亡率、失访率高于城镇组(P<0.05).新农合的实施使农村终末期肾病患者获得了治疗的机会,针对农村患者肾病知晓率低、临床状况差的特点,需加强农村慢性肾病的防治工作.     

ALZHEIMER'S DISEASE AND SOCIALLY EXTENDED MENTATION

Abstract: The leading accounts of the ethics of proxy decision making implicitly draw on internalist conceptions of the philosophy of mind, or so this essay tries to demonstrate. Using the views of Ronald Dworkin as its jumping-off point, the essay argues that accepting the sort of externalism associated with writers such as Putnam and Burge would alter Dworkin's conclusions concerning how we should respond to the current or precedent decisions of people suffering from dementia. Building on the views of Agnieszka Jawarska, it argues that accepting "active" externalism à la Clark and Chambers would provide currently competent people with new resources for establishing the authority of their present values over inconsistent values they might come to entertain should they become demented.     

A computational model of Parkinsonian handwriting that highlights the role of the indirect pathway in the basal ganglia

Parkinsonian handwriting is typically characterized by micrographia, jagged line contour, and unusual fluctuations in pen velocity. In this paper we present a computational model of handwriting generation that highlights the role of the basal ganglia, particularly the indirect pathway. Whereas reduced dopamine levels resulted in reduced letter size, transition of STN–GPe dynamics from desynchronized (normal) to synchronized (PD) condition resulted in increased fluctuations in velocity in the model. We also present handwriting data from PD patients (n = 34) who are at various stages of disease and had taken medication various lengths of time before the handwriting sessions. The patient data are compared with those of age-matched controls. PD handwriting statistically exhibited smaller size and larger velocity fluctuation compared to normal handwriting.     

Musical and verbal memory in Alzheimer’s disease: A study of long-term and short-term memory

Musical memory was tested in Alzheimer patients and in healthy older adults using long-term and short-term memory tasks. Long-term memory (LTM) was tested with a recognition procedure using unfamiliar melodies. Short-term memory (STM) was evaluated with same/different judgment tasks on short series of notes. Musical memory was compared to verbal memory using a task that used pseudowords (LTM) or syllables (STM). Results indicated impaired musical memory in AD patients relative to healthy controls. The deficit was found for both long-term and short-term memory. Furthermore, it was of the same magnitude for both musical and verbal domains whether tested with short-term or long-term memory tasks. No correlation was found between musical and verbal LTM. However, there was a significant correlation between verbal and musical STM in AD participants and healthy older adults, which suggests that the two domains may share common mechanisms.     

The assessment of recognition memory using the Remember/Know procedure in amnestic mild cognitive impairment and probable Alzheimer’s disease

This study used the Remember/Know (R/K) procedure combined with signal detection analyses to assess recognition memory in 20 elders with amnestic mild cognitive impairment (aMCI), 10 patients with probable Alzheimer’s disease (AD) as well as matched healthy older adults. Signal detection analyses first indicated that aMCI and control participants were comparable on general recognition performance. As regards AD patients, they were impaired relative to both aMCI and healthy elders. When assessing Remember and Know responses the aMCI group showed diminished sensitivity for Remember responses but intact Know responses compared to healthy elders. In contrast, AD patients showed decreased sensitivity for both Remember and Know responses compared to control and aMCI participants. The response bias index revealed that AD patients were more liberal than aMCI and control participants when providing Know responses. On the other measures, response bias was comparable between the groups. Overall, this study indicates that the R/K procedure can characterize different aspects of recognition memory performance in persons with aMCI or AD.     

奖惩线索条件下内外倾个体的自主唤醒和行为反应

将停止信号任务和金钱激励延迟任务相结合,使用16导生理记录仪记录被试的生理指标,探讨内外倾者在动机凸显情景下的生理唤醒特点以及反应调节能力。结果发现,隐含奖励和惩罚线索呈现之后,内外倾者的心率增快,内倾者的皮肤电活动显著增强。在停止信号任务中的优势反应阶段,内外倾者表现为对奖励凸显线索刺激的反应时缩短;而在非优势反应阶段,和外倾者相比较,内倾者的抑制反应错误率增高。表明内外倾者在奖惩线索条件下表现出不同的生理唤醒特点和行为反应。