非小细胞肺癌 EG FR 基因突变检测与临床意义

采用荧光PCR法对199例晚期非小细胞肺癌（NSCLC ）组织进行表皮生长因子受体（EGFR ）基因突变检测,分析EGFR基因突变的分布特征及其与临床病理特征的相关性。结果显示56例（28．1％）存在EGFR基因突变,其中27例（13．6％）为外显子19突变,25例（12．6％）为外显子21突变,2例为外显子18突变,1例外显子20突变,1例外显子18和20的共突变。另外,除广东及安徽省铜陵市外,辽宁地区NSCLC患者EGFR基因突变率及主要突变类型与其他地区相符,常见于外显子19、21突变,其中腺癌、不吸烟患者突变率更高,更适宜EGFR-TKI靶向治疗。     

自强意识的初步调查研究

采用录音访谈和开放式问卷要求200名不同性别、年龄、职业、教育程度的成人对“自强”的含义以及在什么时候、什么心理背景下想到“自强”进行了调查,结果表明：(1)公众的自强观主要是指持久的意志力;(2)自强可分为顺境自强、逆境自强、竞争性自强、成长性自强和他向性自强．逆境自强更为公众所赞同;(3)人们回忆起自强意识产生的时间主要在参加工作以后。     

EGFR突变NSCLC二线TKIs治疗优化选择

恶性肿瘤的治疗已经进入驱动基因指导下的个体治疗时代,肺癌患者应该进行多基因检测,特别是表皮生长因子受体（EGFR）基因突变。EGFR基因突变的非小细胞肺癌（NSCLC）患者,如果一线接受了化疗,二线应该选择表皮生长因子受体一酪氨酸酶抑制剂（EGFR—TKIs）。EGFR基因突变的NSCLC患者一线EGFR—TKIs治疗失败后,二线治疗应该是个体化合理选择,包括局部放疗、化疗和继续EGFR—TKIs。目前一代和二代EGFR—TKIs药物之间未见到显著疗效差别。第三代EGFR—TKIs是目前的EGFR—TKIs耐药后的最有希望的选择,特别是针对T790M突变耐药。     

Distortion of probability and outcome information in risky decisions

Substantial evidence indicates that information is distorted during decision making, but very few studies have assessed the distortion of probability and outcome information in risky decisions. In two studies involving six binary decisions (e.g., banning blood donations from people who have visited England, because of “mad cow disease”), student and nonstudent participants distorted their evaluations of probability and outcome information in the direction of their preferred decision alternative and used these biased evaluations to update their preferences. Participants also evaluated the utilities of possible outcomes more positively when the outcomes could follow only from the preferred alternative and more negatively when they could follow only from the competing alternative. Such circular reasoning is antithetical to the normative consequentialist principles underlying decision analysis. Presenting numerical information as precise values or as ranges of values did not significantly affect information distortion, apparently because the manipulation did not affect perceived ambiguity as intended.     

ES、iNOS及bFGF在桥本氏甲状腺炎中表达的研究

采用S-P法检测17例HT患者甲状腺组织切除标本和9例正常甲状腺组织标本中ES、iNOS及bFGF的表达并分析其之间的相关性,以探讨三者在HT发生发展中的作用。结果HT组中ES、iNOS及bFGF的表达程度均明显高于正常组（P均〈0.05）,其中ES与bFGF表达无显著相关性（P〉0.05）,ES与iNOS、bFGF与iNOS的表达均呈显著正相关（r=0.531,r=0.723,P均〈0.05）。结论为在HT中,高表达的ES、iNOS及bFGF在其发生和发展中可能具有重要作用,为研究其病理生理变化和发病机理提供了理论依据。     

肝细胞生长因子受体在胶质母细胞瘤术后放疗过程中的价值评价

为了探讨脑胶质母细胞瘤术后放疗对肝细胞生长因子受体表达规律的影响,对25例胶质母细胞瘤患者进行研究。结果显示肝细胞生长因子受体在复发前接受放疗与未接受放疗的患者中,复发后肝细胞生长因子受体表达及复发时间差异明显（P〈0．05）。因此放疗能对肝细胞生长因子受体在胶质母细胞瘤的表达产生影响,进而影响到其复发时间。     

Number versus continuous quantity in numerosity judgments by fish

A fundamental question in human cognition is how people reason about space. We use a computational model to explore cross-cultural commonalities and differences in spatial cognition. Our model is based upon two hypotheses: (1) the structure-mapping model of analogy can explain the visual comparisons used in spatial reasoning; and (2) qualitative, structural representations are computed by people’s visual systems and used in these comparisons. We apply our model to a visual oddity task, in which individuals are shown an array of two-dimensional images and asked to the pick the one that does not belong. This task was previously used to evaluate understanding of geometric concepts in two disparate populations: North Americans, and the Mundurukú, a South American indigenous group. Our model automatically generates representations of each hand-segmented image and compares them to solve the task. The model achieves human-level performance on this task, and problems that are hard for the model are also difficult for people in both cultures. Furthermore, ablation studies on the model suggest explanations for cross-cultural differences in terms of differences in spatial representations.     

Three ideal observer models for rule learning in simple languages

Children learning the inflections of their native language show the ability to generalize beyond the perceptual particulars of the examples they are exposed to. The phenomenon of “rule learning”—quick learning of abstract regularities from exposure to a limited set of stimuli—has become an important model system for understanding generalization in infancy. Experiments with adults and children have revealed differences in performance across domains and types of rules. To understand the representational and inferential assumptions necessary to capture this broad set of results, we introduce three ideal observer models for rule learning. Each model builds on the next, allowing us to test the consequences of individual assumptions. Model 1 learns a single rule, Model 2 learns a single rule from noisy input, and Model 3 learns multiple rules from noisy input. These models capture a wide range of experimental results—including several that have been used to argue for domain-specificity or limits on the kinds of generalizations learners can make—suggesting that these ideal observers may be a useful baseline for future work on rule learning.     

Computational exploration of metaphor comprehension processes using a semantic space model

Recent metaphor research has revealed that metaphor comprehension involves both categorization and comparison processes. This finding has triggered the following central question: Which property determines the choice between these two processes for metaphor comprehension? Three competing views have been proposed to answer this question: the conventionality view ( Bowdle & Gentner, 2005 ), aptness view ( Glucksberg & Haught, 2006b ), and interpretive diversity view ( Utsumi, 2007 ); these views, respectively, argue that vehicle conventionality, metaphor aptness, and interpretive diversity determine the choice between the categorization and comparison processes. This article attempts to answer the question regarding which views are plausible by using cognitive modeling and computer simulation based on a semantic space model. In the simulation experiment, categorization and comparison processes are modeled in a semantic space constructed by latent semantic analysis. These two models receive word vectors for the constituent words of a metaphor and compute a vector for the metaphorical meaning. The resulting vectors can be evaluated according to the degree to which they mimic the human interpretation of the same metaphor; the maximum likelihood estimation determines which of the two models better explains the human interpretation. The result of the model selection is then predicted by three metaphor properties (i.e., vehicle conventionality, aptness, and interpretive diversity) to test the three views. The simulation experiment for Japanese metaphors demonstrates that both interpretive diversity and vehicle conventionality affect the choice between the two processes. On the other hand, it is found that metaphor aptness does not affect this choice. This result can be treated as computational evidence supporting the interpretive diversity and conventionality views.     

复发转移性乳腺癌患者血浆VEGF水平的临床价值研究

探讨血浆血管内皮生长因子（P-VEGF）在乳腺癌术后复发转移患者中的表达情况及临床意义。采用酶联免疫吸附试验检测50例术后复发转移性乳腺癌患者及20例乳腺良性疾病对照组的P-VEGF含量,同期采用微粒子化学发光法检测术后复发转移性乳腺癌患者血清CEA和CA15-3的表达情况,进行对比研究。结论认为转移肿瘤细胞可产生大量...