The use of genetic test information in insurance: The argument from indistinguishability reconsidered

In the bioethical literature, discrimination in insurance on the basis of genetic risk factors detected by genetic testing has been defended and opposed on various ethical grounds. One important argument in favour of the practice is offered by those who believe that it is not possible to distinguish between genetic and non-genetic information, at least not for practical policy purposes such as insurance decision-making. According to the argument from indistinguishability, the use of genetic test information for insurance purposes should be permitted, because genetic test information is no different from non-genetic medical information in any relevant respect, therefore it would be inconsistent to prohibit the former whilst permitting the latter. This paper discusses and defends this argument and suggests a new, more tenable foundation.     

Doctor's Expertise and Managing Discrepant Information from Other Sources in Genetic Counseling: A Conversation Analytic Perspective

The study examines a recurrent interactional pattern in genetic counseling. It describes clinical geneticists' responses in situations in which clients have presented information from other sources that is potentially discrepant with information given by the doctor. The data consists of 12 video-recorded sessions of genetic counseling in Finland, and the method is conversation analysis. There are two primary ways the doctors respond: either they accept the client's information as such, but show that it is not discrepant with the doctor's information, or they reject the client's information. In the latter case they mitigate the ‘wrongness’ of the client's information. The clinical geneticists seem to be working with a dilemma: they need to find a balance between ensuring correct understanding of the information and showing respect for the expertise of others. A particularly complex case is also analyzed and reflected on.     

The Nature and Significance of Behavioural Genetic Information

In light of the human genome project, establishing the genetic aetiology of complex human diseases has become a research priority within Western medicine. However, in addition to the identification of disease genes, numerous research projects are also being undertaken to identify genes contributing to the development of human behavioural characteristics, such as cognitive ability and criminal tendency. The permissibility of this research is obviously controversial: will society benefit from this research, or will it adversely affect our conceptions of ourselves and each other? When assessing the permissibility of this research, it is important to consider the nature and deterministic significance of behavioural genetic information. Whilst todate there has been much discussion and debate about the properties of genetic information per se and genetic determinism, this has not been applied to behavioural genetic research and its ethical implications. Therefore, this paper elucidates how behavioural genetic information can be distinguished from other types of genetic and non-genetic information and also synthesises the determinative significance of genetic factors for the development of human behavioural traits. Undertaking this analysis enables the ethical issues raised by this research to be debated in an appropriate context and indicates that separate policy considerations are warranted.

     

What are symbols symbols of? Situated action,mythological bootstrapping and the emergence of the Self

This paper addresses the question of how symbols should be understood in analytical psychology and psychoanalysis. The point of view examined focuses on the recent turn to more cognitive and developmental models in both disciplines and briefly reviews and critiques the evolutionary and cognitive arguments. The paper then presents an argument based on dynamic systems theory in which no pre-existing template or structure for either mind or behaviour is assumed. Within the dynamic systems model the Self is viewed as an emergent phenomenon deriving from the dynamic patterns existing in a complex system that includes the physiological characteristics of the infant, the intentional attributions of the caregiver and the cultural or symbolic resources that constitute the environment. The symbol can then be seen as a discrete, and in important ways an autonomous, element in the dynamic system. Conclusions are drawn for further research into the nature of the symbol with implications for both theory and practice in analytical psychology and psychoanalysis.     

Experience and inference: how far will science carry us?

This paper begins with a view of the remarkable understanding of infant and child development that has evolved from research and observation. The limitations of this contribution from science to the multi-dimensional context-based individuality of each human in his or her intersubjective realm are then considered. For a contemporary view we must recognize the influence of the variability of experiences and the inferences drawn from them. Inferences involve symbolization and culturally derived archetypes as illustrated in a clinical example.     

On Modal μ-Calculus and Non-Well-Founded Set Theory

A finitary characterization for non-well-founded sets with finite transitive closure is established in terms of a greatest fixpoint formula of the modal -calculus. This generalizes the standard result in the literature where a finitary modal characterization is provided only for wellfounded sets with finite transitive closure. The proof relies on the concept of automaton, leading then to new interlinks between automata theory and non-well-founded sets.     

Categorical Abstract Algebraic Logic Metalogical Properties

Metalogical properties that have traditionally been studied in the deductive system context (see, e.g., [21]) and transferred later to the institution context [33], are here formulated in the -institution context. Preservation under deductive equivalence of -institutions is investigated. If a property is known to hold in all algebraic -institutions and is preserved under deductive equivalence, then it follows that it holds in all algebraizable -institutions in the sense of [36].     

Given-New Ordering Effects on the Production of Scrambled Sentences in Japanese

Across many languages, speakers tend to produce sentences so that given (previously referred to) arguments are mentioned before new arguments; this is termed given-new ordering. We explored the nature of such given-new effects in Japanese using a procedure following Bock and Irwin (1980). Speakers encoded and then recalled canonical (e.g., okusan-ga otetsudaisan-ni purezento-o okutta, the housewife gave the housekeeper a present) or scrambled (okusan-ga purezento-o otetsudaisan-ni okutta) dative targets when prompted by a statement-question sequence. The prompting statement established one nonsubject argument of the dative target as given, leaving the other nonsubject argument as new. Previous mention was either with lexically identical content (e.g., otetsudaisan or purezento) or with lexically distinct but nearly synonymous content (meidosan, housemaid or okurimono, gift). Results showed that speakers produced canonical or scrambled word orders so that given arguments were mentioned before new, but especially when the previous mention of the given argument occurred with lexically identical content (replicating Bock and Irwin's English effect). These results show that the production of Japanese scrambled and canonical word orders is sensitive to given versus new status (as in English), implying that given-new ordering arises at the stage of sentence production where scrambling effects are realized.     

Nonparametric IRT: Testing the bi-isotonicity of isotonic probabilistic models (ISOP)

Nonparametric tests for testing the validity of polytomous ISOP-models (unidimensional ordinal probabilistic polytomous IRT-models) are presented. Since the ISOP-model is a very general nonparametric unidimensional rating scale model the test statistics apply to a great multitude of latent trait models. A test for the comonotonicity of item sets of two or more items is suggested. Procedures for testing the comonotonicity of two item sets and for item selection are developed. The tests are based on Goodman-Kruskal's gamma index of ordinal association and are generalizations thereof. It is an essential advantage of polytomous ISOP-models within probabilistic IRT-models that the tests of validity of the model can be performed before and without the model being fitted to the data. The new test statistics have the further advantage that no prior order of items or subjects needs to be known.