Aphasia type and aging

We analyzed the relationship between age and clinical type of aphasia in 167 right-handed men who had suffered cerebrovascular accidents. Patients with unequivocal diagnoses as Broca's, Wernicke's, anomic, conduction, and global aphasics were considered. The median age of the Broca's group (51 years old) was significantly lower than that of the total group (55.8 years old), while the median age of the Wernicke's group was significantly higher (63 years old). Moreover the incidence of Wernicke's aphasia increased steadily with age, while incidence of the other types of aphasia peaked in the sixth decade and then diminished with increasing age.     

Dichhaptic hand-order effects with verbal and nonverbal tactile stimulation

The palms of normal right-handed subjects were stimulated dichhaptically, i.e., with competing, bimanually presented tactile stimuli consisting of pairs of letters, pairs of digits, or pairs of line orientations. The subjects were required to identify both stimuli in a particular order, and order of report was compared between hands and across stimulus materials. Results indicated right-hand superiority for letters and left-hand superiority for lines; no hand differences occurred for digits. However, observed differences between hands appeared with second reports only, suggesting that measures of tactile storage are more sensitive to laterality differences than measures closer in time to actual stimulation.     

A study of spelling in aphasia

To secure systematic information on spelling abilities following damage to the dominant hemisphere, a test probing performance in three modalities of response was administered to a group of aphasic patients. Except for a predictable deficit among anterior aphasics in oral spelling, anterior and posterior aphasics exhibited comparable performances on the measures of spelling. However, anterior and posterior aphasics differed from one another on the kinds of words they most accurately spelled, the errors they were prone to make, and certain strategies which they characteristically adopted. These results suggest two alternative approaches to spelling: one approach, common in posterior aphasics, entails choosing letter combinations on the basis of their customary sounds; a second approach, common among anterior aphasics, appears to rely on a partially preserved image of the word's appearance.     

Quantitative CT scan studies in aphasia. I. Infarct size and CT numbers

Infarct si?e (number of 1-mm² pixels in the lesion) on CT scans of 30 aphasia patients was obtained with a semiautomated computer program. The mean number of lesion pixels present per slice containing lesion was approximately 500 for mild aphasias (transcortical motor and conduction), 700 for Wernicke's, 1000 for Broca's, 1500 for mixed, and 2000 for globals. These differences were significant for $\text{11}\text{15}$ of the group pairwise comparisons. When lesion locus was controlled for in the anterior/posterior plane, 73–100% of the aphasia patients were correctly classified as to type of aphasia by a discriminant analysis utilizing only the number of lesion pixels present on two CT slices. Different slice combinations were used for different aphasia group comparisons. There was a significant correlation between severity of aphasia and lesion size. There was a significant correlation between lesion size and the CT numbers in the lesion. This type of analysis may be useful to predict the prognosis for recovery potential in aphasics who have CT scans performed at 2 months poststroke.     

帕金森病人的图形辨别障碍

对56名帕金森病人用视觉形状辨别测验(VFDT)进行了测查,44名年龄、文化水平与帕金森组相当的正常人作为对照组。结果发现帕金森病人对图形辨别有明显障碍。对帕金森病人在图形辨别障碍中的特点进行了分析,并对其可能机制进行了讨论。     

Seeing Through Technology

In examining representations of cities, disease, and human biology, this paper reflects on what technologies reveal of the conditions to which they’re turned.

Adaptive Tasks in Multiple Sclerosis: Development of an Instrument to Identify the Focus of Patients' Coping Efforts

Objective : Adaptive tasks, referring to the subjective evaluation of disease-related stressors in relation to personal concerns, have been neglected in the extensive literature on coping with chronic disease. In this study, the development of an instrument for measuring adaptive tasks is described: the Questionnaire Adaptive Tasks in Multiple Sclerosis (QuAT-MS). Method : The QuAT-MS is based on a bottom-up categorization of patients' statements on the losses, threats, and challenges brought about by their disease, and employs 10 scales to measure the importance attached to particular disease-related stressors. Validity and reliability of this bottom-up categorization were established in a sample of MS patients ( N = 259) by examining their associations with related concepts relevant in adaptation to disease, such as coping (CISS), coping resources (LOT, self-efficacy), and quality of life (SIP). We also investigated whether patients' backgrounds and disease characteristics were related to adaptive tasks. Results : Adaptive tasks are more closely related with concepts relevant for adaptation (coping and coping resources) than with physical functioning (SIP) and disease-related characteristics (illness duration). Adaptive tasks are also associated with gender and level of education. Conclusion : It is concluded that adaptive tasks can be distinguished from related concepts like coping and quality of life. Furthermore, the QuAT-MS offers a reliable and patient-centred instrument for measuring the tasks which MS patients identify in their adaptation process.     

Empirical,Logical and Philosophical Arguments Against Cigarette Smoking as a Pharmacologically Compelled Act

The fundamental hypothesis of the disease model of nicotine addiction states that, following a regime of chronic smoking, further smoking becomes a pharmacologically compelled rather than a chosen act. Despite it’s public and professional popularity as an explanation for why people continue to smoke in spite of a deteriorating quality of life, the validity of this hypothesis has been critically undermined by the state of evidence in four domains: inconclusive empirical evidence of withdrawal severity as a potent predictor of quit outcome; methodological problems concerning the measurement of factors which maintain smoking; logical problems with the interpretation of factors which maintain smoking, in particular, failures to discriminate reflexive and mediated actions in explanations of why people smoke; and philosophical problems with conceptualisations of human action as determined rather than willed. In light of these problems, it is argued that evidence on the nature of nicotine addiction is not well explained by the disease model, but rather, posits smoking primarily as a decision-making process influenced peripherally by the pharmacologic effects of nicotine on the brain and body.

A pox on the mind: Disjunction of attention and memory in the processing of physical disfigurement

The unfavorable treatment of people with physical disfigurements is well-documented, yet little is known about basic perceptual and cognitive responses to disfigurement. Here, we identify a specialized pattern of cognitive processing consistent with the hypothesis that disfigurements act as heuristic cues to contagious disease. Disfigurements are often invariant across time and difficult to conceal, and thus observers can detect the presence of such cues without necessarily remembering the particular individuals bearing these cues. Indeed, despite the fact that disfigured faces were especially likely to hold disease-sensitive perceivers’ attention (Study 1), disfigured individuals were often confused with one another and thus not well remembered later (Study 2), revealing a disjunction of the typical relationship between elevated attention and elevated memory. We discuss the implications of our results for stigmatization of people with and without physical abnormalities and suggest the possibility that cognitive mechanisms for processing social information may be functionally tuned to the variant nature of important cues.