Effects of iron deficiency in infancy on patterns of motor development over time

This longitudinal study of the effects of iron deficiency in infancy assessed motor development over time in 185 healthy Costa Rican children who varied in iron status at 12-23 months. Longitudinal analyses (hierarchical linear modeling) used the Bayley Psychomotor Index before and both 1 week and 3 months after iron treatment in infancy and the Bruninks-Oseretsky Test of Motor Proficiency - long form at 5 years and short form at 11-14 years. Children with chronic severe iron deficiency in infancy had lower motor scores at the beginning of the study and a lower but parallel trajectory for motor scores through early adolescence. Thus, there was no evidence of catch-up in motor development, despite iron therapy in infancy that corrected iron deficiency anemia in all cases.     

Information sources for noun learning

Why are some words easier to learn than others? And what enables the eventual learning of the more difficult words? These questions were addressed for nouns using a paradigm in which adults were exposed to naturalistic maternal input that was manipulated to simulate access to several different information sources, both alone and in combination: observation of the extralinguistic contexts in which the target word was used, the words that co‐occurred with the target word, and the target word's syntactic context. Words that were not accurately identified from observation alone were both abstract (e.g., music) and concrete (e.g., tail). Whether a noun could be learned from observation depended on whether it labeled a basic‐level object category (BLOC). However, the difference between BLOC labels and non‐BLOC labels was eliminated when observation was supplemented with linguistic context. Thus, although BLOC labels can be learned from observation alone, non‐BLOC labels require richer linguistic context. These findings support a model of vocabulary growth in which an important role is played by changes in the information to which learners have access.     

Return of fear in a human differential conditioning paradigm caused by a return to the original acquistion context

In a differential human fear conditioning paradigm evidence for ABA-renewal was obtained manipulating the lighting in the experimental room. During acquisition in either a dark or illuminated room, one neutral slide was sometimes paired with a loud aversive noise whereas another slide was not. Subsequently, extinction took place in the opposite lighting context. When afterwards the participants were tested again in the original acquisition context, measurements revealed a recovery of the conditioned electrodermal response and an increase in the retrospective verbal US-expectancy ratings. No response recovery was obtained in an AAA-group that received acquisition, extinction and test trials in one and the same context. Several theoretical explanations for this type of return of fear as well as implications for clinical practice are discussed.     

Chronometric studies of numerical cognition in five-month-old infants

Developmental research suggests that some of the mechanisms that underlie numerical cognition are present and functional in human infancy. To investigate these mechanisms and their developmental course, psychologists have turned to behavioral and electrophysiological methods using briefly presented displays. These methods, however, depend on the assumption that young infants can extract numerical information rapidly. Here we test this assumption and begin to investigate the speed of numerical processing in five-month-old infants. Infants successfully discriminated between arrays of 4 vs. 8 dots on the basis of number when a new array appeared every 2 s, but not when a new array appeared every 1.0 or 1.5 s. These results suggest alternative interpretations of past findings, provide constraints on the design of future experiments, and introduce a new method for probing infants' enumeration process. Further experiments using this method provide initial evidence that infants' enumeration mechanism operates in parallel and yields increasingly accurate numerical representations over time, as does the enumeration mechanism used by adults in symbolic and non-symbolic tasks.     

Interference effects demonstrate distinct roles for visual and motor imagery during the mental representation of human action

Four experiments were completed to characterize the utilization of visual imagery and motor imagery during the mental representation of human action. In Experiment 1, movement time functions for a motor imagery human locomotion task conformed to a speed-accuracy trade-off similar to Fitts' Law, whereas those for a visual imagery object motion task did not. However, modality-specific interference effects in Experiment 2 demonstrate visual and motor imagery as cooperative processes when the action represented is tied to visual coordinates in space. Biomechanic-specific motor interference effects found in Experiment 3 suggest one basis for separation of processing channels within motor imagery. Finally, in Experiment 4 representations of motor actions were found to be generated using only visual imagery under certain circumstances: namely, when the imaginer represented the motor action of another individual while placed at an opposing viewpoint. These results suggest that the modality of representation recruited to generate images of human action is dependent on the dynamic relationship between the individual, movement, and environment.     

Interlimb coordination in prosthetic walking: effects of asymmetry and walking velocity

The present study focuses on interlimb coordination in walking with an above-knee prosthesis using concepts and tools of dynamical systems theory (DST). Prosthetic walkers are an interesting group to investigate from this theory because their locomotory system is inherently asymmetric, while, according to DST, coordinative stability may be expected to be reduced as a function of the asymmetry of the oscillating components. Furthermore, previous work on locomotion motivated from DST has shown that the stability of interlimb coordination increases with walking velocity, leading to the additional expectation that the anticipated destabilizing effect of the prosthesis-induced asymmetry may be diminished at higher walking velocities. To examine these expectations, an experiment was conducted aimed at comparing interlimb coordination during treadmill walking between seven participants with an above-knee prosthesis and seven controls across a range of walking velocities. The observed gait patterns were analyzed in terms of standard gait measures (i.e., absolute and relative swing, stance and step times) and interlimb coordination measures (i.e., relative phase and frequency locking). As expected, the asymmetry brought about by the prosthesis led to a decrease in the stability of the coordination between the legs as compared to the control group, while coordinative stability increased with increasing walking velocity in both groups in the absence of a significant interaction. In addition, the 2:1 frequency coordination between arm and leg movements that is generally observed in healthy walkers at low walking velocities was absent in the prosthetic walkers. Collectively, these results suggest that both stability and adaptability of coordination are reduced in prosthetic walkers but may be enhanced by training them to walk at higher velocities.     

Development of preferences for the human body shape in infancy

Two studies investigated the development of infants' visual preferences for the human body shape. In Study 1, infants of 12, 15 and 18 months were tested in a standard preferential looking experiment, in which they were shown paired line drawings of typical and scrambled bodies. Results indicated that the 18-month-olds had a reliable preference for the scrambled body shapes over typical body shapes, while the younger infants did not show differential responding. In Study 2, 12- and 18-month-olds were tested with the same procedure, except that the typical and scrambled body stimuli were photographic images. The results of Study 2 again indicated that only the 18-month-olds had a reliable preference for the scrambled body shapes. This finding contrasts sharply with infants' precocious preferences for human faces, suggesting that infants' learning about human faces and human bodies follow different developmental trajectories.     

The council of Europe’s instruments on biomedical research: how is conflict of interest addressed?

Conflict of interest is an issue that has been put in the spotlight by the commercial application of the new biomedical technologies. This paper presents the approach of the Council of Europe and the binding legal instruments to deal with this problem. The main focus is on the Convention on Human Rights and Biomedicine, and its draft additional Protocol on Biomedical Research. An earlier version of this paper was presented at an International Conference on “Conflict of Interest and its Significance in Science and Medicine” held in Warsaw, Poland on 5–6 April, 2002. The views expressed are personal and do not necessarily reflect any official position of the Council of Europe.     

Ability rise in NAEP and narrowing ethnic gaps?

US National Assessment of Educational Progress (NAEP) results from 1971 to 2008 enable four different effects to be distinguished: Cohort rise effects, gap-narrowing between ethnic groups, trends due to demographic changes in by NAEP listed or not listed ethnic groups. NAEP means and percentiles in reading and mathematics were transformed to conventional IQs and SDs. The total increase from 1971 to 2008 was in the scale of 4.34 IQ points (dec = 1.17 IQ per decade). The ability distribution became more homogenous (down from SD = 15.00 in 1971 to SD = 13.56 in 2008). Increases were larger for younger students (9-year olds: 2.02 IQ per decade; 13-year olds: 1.20; 17-year olds: 0.30); larger at the lower ability level (10th percentile dec = 1.79 vs. 90th percentile dec = 1.03). The largest increase was for Blacks (Whites dec = 1.29 IQ, Hispanics 2.27, Blacks 3.04). White–Hispanic-differences were reduced from 11.59 to 8.46 IQ, White–Black from 16.33 to 9.94 IQ. If the racial composition of the population had not changed, the mean gain for the 17-year-old group would have been 2.47 IQ points higher. Had the gap between Whites and the two other groups not narrowed, the mean gain would have been 1.70 IQ points lower. Demographic change has accounted for a loss of 2.47 IQ points and according to cognitive human capital theory $2001 GDP per capita per year, but total ethnic gap-narrowing has provided a gain of $1377.     

Tuning Clinical Recruitment around Cultural Taboos in a Human Microbiome Study

ABSTRACT

Human microbial communities are bodies of microorganisms that reside in or on different body parts. Importantly, they have been found to affect human health. However, scientific research on human microbial communities has created new challenges for human subject recruitment. First, individuals are asked to collect samples of bodily substances that can be seen as repulsive (e.g. feces and urine). Second, because scientists want to understand how human microbial communities evolve over time, individuals are asked to commit to a regular sample collection for extended periods of time. A longitudinal qualitative study of the work of scientists, physicians, research staff, and study coordinators involved in a human microbiome research project has found that these actors can bypass some aspects of these recruitment and retention challenges through ‘tuning work’. Tuning work is a collaborative process where professionals agree to adjust their practices towards shared goals. Such professionals reconfigure their work practices, personal routines, and the study protocol in an effort to obviate cultural taboos against handling bodily substances. The burden of long-term participation provides fewer opportunities for tuning work for these professionals, however. As such, long-term commitment by human subjects remains a recruitment and retention obstacle.