Tuning Clinical Recruitment around Cultural Taboos in a Human Microbiome Study

ABSTRACT

Human microbial communities are bodies of microorganisms that reside in or on different body parts. Importantly, they have been found to affect human health. However, scientific research on human microbial communities has created new challenges for human subject recruitment. First, individuals are asked to collect samples of bodily substances that can be seen as repulsive (e.g. feces and urine). Second, because scientists want to understand how human microbial communities evolve over time, individuals are asked to commit to a regular sample collection for extended periods of time. A longitudinal qualitative study of the work of scientists, physicians, research staff, and study coordinators involved in a human microbiome research project has found that these actors can bypass some aspects of these recruitment and retention challenges through ‘tuning work’. Tuning work is a collaborative process where professionals agree to adjust their practices towards shared goals. Such professionals reconfigure their work practices, personal routines, and the study protocol in an effort to obviate cultural taboos against handling bodily substances. The burden of long-term participation provides fewer opportunities for tuning work for these professionals, however. As such, long-term commitment by human subjects remains a recruitment and retention obstacle.     

Rights for me but not for thee: Restriction of human rights based on group membership and threat perceptions

Policies aimed at limiting border crossing and influencing other cultural values have been enacted domestically and internationally in the name of security. However, do these decisions concerning such tradeoffs resonate equally across all groups? In two studies, we probe the moderating impact of intergroup threat on the inclination to restrict human rights. In Study 1, we employ a unique economic tradeoff model to directly compare the value of security with the rights of either citizens or non-citizens. In Study 2, we broaden these findings by examining whether support for infringements on the right to privacy varies among diverse groups. Across both studies, our results consistently show that an increase in intergroup threat corresponds to heightened restriction of rights, but only when contemplating individuals who are not citizens, such as non-citizens, residents, or foreigners. We propose future research directions that include promoting the concept of a global community and exploring altruistic behaviours associated with rights protection.     

Animals,humans and x-men: Human uniqueness and the meaning of personhood

Research in animal intelligence suggests to some that humans are different only in degree from animals, possibly eroding the traditional theological doctrine of the imago dei. In this paper, several critical boundary areas between humans and animals are examined for scientific evidence about human distinctiveness. These include communication and language capacity, cultural creativity, spirituality, and ethical capacity. Chimpanzee language studies and research in Neanderthal mentality are examined as the closest known natural approximations to human communication and intelligence. The implications of the findings are explored in relation to human culture, ethics, and spirituality in a context consistent with evolutionary continuity. Aspects of human uniqueness are apparent, can be fruitfully encompassed in the idea of personhood, and are coherent with Trinitarian theology's anthropological focus.     

Personhood: Elusive But Not Illusory

Bioethics as a field has been fortunate that its values and concerns have mirrored the values and concerns of society. In light of the September 11th attacks, it is possible that we are witnessing the beginning of a transition in American culture, one fraught with implications for bioethics. The emphasis on autonomy and individual rights may come to be tempered by greater concern over the collective good. Increased emphasis on solidarity over autonomy could greatly alter public response to research abuses aimed at defense from bioterrorism, to privacy of genetic information, and to control of private medical resources to protect the public health.     

Looking at others through implicitly or explicitly prejudiced eyes

It is well known that we utilize internalized representations (or schemas) to direct our eyes when exploring visual stimuli. Interestingly, our schemas for human faces are known to reflect systematic differences that are consistent with one's level of racial prejudice. However, whether one's level or type of racial prejudice can differentially regulate how we visually explore faces that are the target of prejudice is currently unknown. Here, White participants varying in their level of implicit or explicit prejudice viewed Black faces and White faces (with the latter serving as a control) while having their gaze behaviour recorded with an eye-tracker. The results show that, regardless of prejudice type (i.e., implicit or explicit), participants high in racial prejudice examine faces differently than those low in racial prejudice. Specifically, individuals high in explicit racial prejudice were more likely to fixate on the mouth region of Black faces when compared to individuals low in explicit prejudice, and exhibited less consistency in their scanning of faces irrespective of race. On the other hand, individuals high in implicit racial prejudice tended to focus on the region between the eyes, regardless of face race. It therefore seems that racial prejudice guides target-race specific patterns of looking behaviour, and may also contribute to general patterns of looking behaviour when visually exploring human faces.     

Psychoanalysis and the regulation of society

Multiple losses can be associated with both infertility and child sexual abuse. This work seeks to explore the ways in which such connections can affect a survivor who subsequently experiences infertility and who may choose to pursue medical treatment. The potential consequences of such mirroring are explored from the perspective of counselling practice under the provisions of the Human Fertilisation and Embryology Act (1990).     

Using the visual world paradigm to study language processing: a review and critical evaluation

We describe the key features of the visual world paradigm and review the main research areas where it has been used. In our discussion we highlight that the paradigm provides information about the way language users integrate linguistic information with information derived from the visual environment. Therefore the paradigm is well suited to study one of the key issues of current cognitive psychology, namely the interplay between linguistic and visual information processing. However, conclusions about linguistic processing (e.g., about activation, competition, and timing of access of linguistic representations) in the absence of relevant visual information must be drawn with caution.     

Differential dynamics of spatial and non-spatial stimulus-response compatibility effects: a dual task LRP study

Choice reaction times are shorter when stimulus and response features are compatible rather than incompatible. Recent studies revealed that spatial compatibility effects in Simon tasks are strongly attenuated when there is temporal overlap with a different high-priority task. In contrast, non-spatial variants of the Simon task appear to be unaffected by task overlap. The present study used the lateralized readiness potential (LRP) within a dual task design to elucidate the dynamics underlying these differential effects for a color and a spatial variant of the Simon task. In the color version there was no sign of early response priming by irrelevant stimulus features in the LRP. The color compatibility effect was independent of task overlap and reflected in the LRP onset latency. In contrast, in the spatial version, priming by irrelevant stimulus location showed up and was mirrored by early LRP activation. Response priming and the corresponding Simon effect, however, were present only in case of little temporal overlap with the primary task. The absence of spatial compatibility effects at strong temporal overlap suggests that response conflicts due to stimulus-related priming depend on the availability of processing resources.