The human lateral lemniscus and its nuclei: The human auditory pathways: A quantitative study

Quantification of the human lateral lemniscus and its nuclei in 15 brains of patients without hearing impairment revealed these average values: Cross-sectional surface area of the bundle at the level of the nucleus of cranial nerve IV of 2.5 mm², fiber density of 77,000/mm²; 194,000 total fibers on each side; grouping of the nerve cells in three nuclei (olive remnant, ventral, and dorsal) the largest of which is the ventral; cell density in the olive remnant of 5009/mm³, in the ventral nucleus of 15,184/mm³, and 13,169 cells per mm³ in the dorsal nucleus; total cell populations in all nuclei of 20,063 on the left and 26,137 on the right; glial-neuronal index of 9.2; cell dimensions of 23.6 × 15.4 microns in the olive remnant and 21.2 × 12.2 in the other nuclei; combined nuclear volume of 1.91 mm³. Loss of neurons was not apparent in the aged brains but a significant reduction in counts of axons and in lemniscal bulk appeared in two of the older brains of the series (77 and 91 years).     

Paralinguistic aspects of auditory comprehension in aphasia.

Eight severe aphasics were given sentences with either emotional or neutral content, presented once directly by the examiner and once via a tape recorder. Sentences with emotional content produced a greater number of responses than their neutral counterparts. Sentences spoken by the examiner also produced a significantly greater number of responses than the same items originating from a tape recorder. These results confirm the view that elements not related to the linguistic aspects of a message (and therefore referred to as paralinguistic) play a significant role in auditory comprehension.     

The relation between gesture and language in aphasic communication

Effective communication in aphasia depends not only on use of preserved linguistic capacities but also (and perhaps primarily) on the capacity to exploit alternative modalities of communication, such as gesture. To ascertain the capacity of aphasic patients to use gesture in their spontaneous communication, informally structured interviews were conducted with two Wernicke's aphasics and two Broca's aphasics, as well as with four normal controls. The performances of the patient groups were compared on the physical parameters of gesture, the points in the communication where gestures occurred, and several facets of the semantics and pragmatics of gesture. Generally speaking, the gestures of the aphasics closely paralleled their speech output: on most indices, the performance of the Wernicke's aphasics more closely resembled that of the normal controls. Wernicke's aphasics differed from normals in the clarity of their language and gestures: While individual linguistic units were often clear, the relation among units was not. In contrast, the Broca's aphasics equaled or surpassed the normal controls in the clarity of their communications. The results offer little support for the view that aphasic patients spontaneously enhance their communicative efficacy through the use of gesture; these findings can, however, be interpreted as evidence in favor of a “central organizer” which controls critical features of communication, irrespective of the modality of expression.     

The game of the name: An examination of linguistic reference after brain damage

Two aspects of naming have generally been examined in aphasics: the appreciation of a single property of a concept and the ability to use the names of fully elaborated concepts. In applying to aphasics a recently proposed model of semantic organization—one which allows the simultaneous examination of these two aspects—two studies were conducted: Anterior and posterior aphasics were asked (1) to name members of superordinate categories, their responses being converted into prototypicality scores (the degree to which a member of a category resembles an ideal member of that category) and (2) to differentiate between more or less prototypical members of a category and their superordinates. The results revealed that, while anterior and posterior aphasics differ in their use of the names representing fully elaborated concepts, these groups show no differences in terms of the appreciation of a single property of a concept. The implications of these findings for reference were discussed.     

Different patterns of mnemonic deficits in two organic amnestic syndromes

A recall and recognition memory study of Korsakoff and post-herpes encephalitis patients employing percentage correct recall and the statisticd′ derived from signal detection theory supports Lhermitte's contention that these two patient groups represent two distinct organic amnesia syndromes. Post-herpes encephalitis patients show little evidence of encoding and storage of information. In contrast recognition memory of Korsakoff and normal control subjects was essentially similar for truly novel information. Recognition memory for English words was markedly impaired for Korsakoff patients and worsened with increased semantic organization of the material. In light of our findings it would seem advisable to utilize homogeneous groups, with respect to brain pathology, when studying memory processes in organic patients.     

A structural determinant of hemispheric processing of pictorial material

A qualitative difference of processing type by the two cerebral hemispheres was demonstrated in a picture arrangement task which involved a concept of temporal sequence. Half the sequences were designed to rely on analytic categorical processes and half on configurational processes. The subjects were patients with unilateral hemispheric damage of vascular etiology. Using two measures of performance, latency and errors, patients with right hemisphere damage were seen to be relatively impaired on those sequences designed to employ hypothesized right hemisphere (configurational) processing and patients with left hemisphere damage were seen to be relatively impaired on those sequences designed to employ hypothesized left hemisphere (categorical) processing.     

Comprehension disorders in aphasia: a historical review.

This paper reviews the clinical reports and theoretical inferences made by early scientists in regard to the impairment of auditory comprehension so often found in aphasics. It first presents an analysis of the literature on and the interpretation of comprehension disorders in aphasia up to the time of Pierre Marie and Arnold Pick. It then reviews early attempts to assess and quantify receptive impairment. Finally, it discusses the historical origin of some of the questions on comprehension currently under investigation by contemporary researchers.     

Dimensional structure and psychopathology correlates of the fear survey schedule (FSS-III) in a phobic population: A factorial definition of agoraphobia

The responses of 703 non-institutionalized phobics to the Fear Survey Schedule (FSS-III) were factor-analyzed utilizing a principal components procedure. Factors previously identified in student, adolescent and ‘non-phobic patient’ populations—(I) Social Anxiety, (III) Fears related to Bodily Injury, Death and Illness. (IV) Fear of Display to Sexual and Aggressive Scenes, (V) Small Animal Fears—were replicated. Additionally, an Agoraphobia (II) factor, corroborating recent findings by Hallam and Hafner (1978), and pointing to the specificity of this fear, emerged. Due to substantially high intercorrelations found, the Social Inadequacy dimension of the Symptom Checklist (SCL-90) and the Social Anxiety scale (I), on the one hand, and the Agoraphobic dimension of the SCL-90 and the Agoraphobia scale (II), on the other, could be used interchangeably with phobic populations. A higher-order factor analysis run on psychopathology scales employed, including factored FSS scales, yielded three components, (1) Neuroticism, (2) Phobia and (3) Agoraphobia. Opportunity was taken to define the Agoraphobic Syndrome empirically. A specific Somatization dimension was as highly related to Neuroticism, as to the higher-order Agoraphobic cluster, clearly supporting clinical observations with regard to the Agoraphobic syndrome. Some interesting findings are focused upon and discussed.