热休克蛋白7O在动脉粥样硬化发病中的双重作用

大多研究表明,热休克蛋白70通过抗凋亡、抗氧化及抗炎症反应而在动脉粥样硬化发病中起保护作用。但亦有研究表明,热休克蛋白70通过促凋亡、促进炎症反应而在动脉粥样硬化的发生发展中起促进作用。说明热休克蛋白70在动脉粥样硬化发病中有双重作用,进行基础研究和临床干预时应考虑到其双面性。     

When children succeed in changing their responses: Insights from three versions of a flexible categorization task

Cognitive flexibility is a hallmark of human cognition, but its development is still poorly understood. The present work examined the flexibility of categorization in preschool children. Thirty-three participants aged 3–4 years were divided into three groups, with each group receiving a different version of a flexible categorization task in which the targets belonged to two distinct categories. These versions manipulated the type of questions that were asked and the alternation of shape and color games. The children exhibited flexibility when the questions were specific (or asked about attributes). The results support the idea that instructions play a role in children’s performance in sorting tasks. Considering cognitive flexibility as an expression of the interaction between children’s knowledge and abilities on the one hand and the structure, specifics, or demands of the task on the other can help clarify what cognitive flexibility is and how it develops.     

Mitigating the Harmful Effect of Perceived Organizational Compliance on Trust in Top Management: Buffering Roles of Employees’ Personal Resources

This study considers how employees’ POC—defined as their beliefs that the organizational climate stifles change and values compliance with the status quo—reduce their trust in top management, as well as how this negative relationship might be buffered by access to two personal resources that support organizational change: openness to experience and affective commitment to change. Data from a sample of Pakistan-based organizations reveal that POC reduce trust in top management, but this effect is weaker at higher levels of openness to experience and affective commitment to change. These findings are significant in that they indicate that employees who operate in organizational climates marked by “yea-saying” can counter the difficulty of improving their job situation by drawing from adequate personal resources.     

La relation entre l’usage professionnel des technologies numériques et l’addiction au travail médiatisée par les demandes psychologiques au travail : quelles différences entre les hommes et les femmes ?

Considered as an additional job demand, the use of technologies for work-related reasons could increase psychological demands at work, favoring the appearance of workaholism. Our study examines the impact of the frequency of this use on psychological demands at work and workaholism in a sample of 223 people at work from various professional backgrounds, by verifying whether there are differences between men and women. The results showed that the use of technologies (desktop computer, laptop, tablet, smartphone/mobile phone) for work-related reasons increases psychological demands felt at work, consequently favoring the appearance of the two components of workaholism (working excessively and working compulsively) in men and women. In addition, the results show us gender differences: the strength of the relationship between the use of technologies for work-related reasons and working excessively, partially mediated by psychological demands at work, was slightly higher among men than in women; strength of the relationship between the use of technologies for work-related reasons and working compulsively, partially mediated by psychological demands at work, was found just among men, whereas a full mediation was found among women. This research highlights the importance of investigating the mechanisms that may explain how the use of technologies for work-related reasons could enhance the risk of work addiction, by considering gender differences.     

任务需求对基于位置的返回抑制和基于颜色的重复劣势效应的影响

在 3个实验中探讨了任务需求对基于位置的返回抑制和基于颜色的重复劣势效应的影响。实验 1选取2 3名本科生被试 ,在把所有刺激都呈现在中央视觉上的颜色辨别任务中 ,发现颜色重复条件下的反应时明显长于非重复条件下的反应时 ,出现了显著的基于颜色的重复劣势效应 ,而且它的量显著大于简单检测任务中基于颜色的重复劣势效应量。实验 2和 3在实验 1的基础上加入空间不确定性 ,分别选取 2 2名和 2 3名本科生被试 ,并要求他们分别完成颜色辨别任务和简单检测任务。结果发现 ,在颜色辨别任务中 ,既获得了基于空间的返回抑制 ,又获得了基于颜色的重复劣势效应 ,而且二者之间没有交互作用 ,即它们各自独立地发挥作用 ;而在简单检测任务中 ,只获得了基于空间的返回抑制。 3个实验的结果表明 ,在一种实验情境下出现基于何种刺激特性的重复劣势效应 ,以及其量的大小完全取决于实验中的任务需求。在文章最后还将本研究结果与一种选择性注意领域内普遍抑制模型相结合 ,进行了深入讨论     

The influence of task characteristics on younger and older adult motor overflow

This study investigated the influence of attentional and motor demands on motor overflow in 17 healthy young (18–35 years) and 17 older adults (60–80 years). Participants performed a finger pressing task by exerting either 33% or 66% of their maximal force output using their dominant or nondominant hand. Overflow was concurrently recorded in the passive hand. Attention was manipulated via a tactile stimulus presented to one or both hands for certain trials. Results showed that older adults exhibited greater overflow than young adults and that the effect of target force was exacerbated in older adults. Further, only older adult overflow was increased when tactile stimulation was directed to one or both hands. Increased overflow in older adults may result from bilateral cortical activation that is influenced by increased task demands. To perform comparatively to younger adults, older adults may compensate for age-related brain changes by recruiting an increased cortical network.     

Children's Representation of Long Duration: When Memory and Attention Meet in Processing Time

The concepts of the memory and attentional models were examined in children's and adults’ time perception in a long duration. One hundred twenty-one children in preschool through Grade 2 and 29 adults for Study 1 and 93 second-, fourth-, and sixth-grade students and 40 adults for Study 2 judged durations of tasks that varied in interest levels and cognitive demands. In Study 1, children overestimated but adults underestimated the movie that they found to be interesting. However, in Study 2, both children and adults consistently overestimated the duration of puzzles they found to be interesting. In a long duration, the findings were more in line with the memory model than with the attention model. A qualitative change also emerged in middle childhood in the way children kept track of time; this difference may influence the developing perception of long duration in children's representation. Implications of the findings are further discussed in examining the perception of long duration.     

Crossover of job demands and emotional exhaustion within teams: a longitudinal multilevel study

This study investigated the crossover of job demands and emotional exhaustion among team members and the moderating effect of cohesiveness and social support on this process. Participants were 310 employees of an employment agency in the Netherlands, working in one of 100 teams. Multilevel analysis using a longitudinal design did not reveal a main effect of crossover. However, consistent with the study's hypotheses, the results showed a moderating effect of team cohesiveness and social support. We detected crossover of job demands and emotional exhaustion across time from the group to individual team members only in teams characterized by high levels of cohesiveness and social support. Teams characterized by low levels of cohesiveness and social support showed no crossover of job demands and exhaustion. The findings demonstrate that team-level moderators play an important role in crossover processes. Moreover, social support and cohesiveness may not always be positive.