The Motor Profile of Primary School-Age Children with a 22q11.2 Deletion Syndrome (22q11.2DS) and an Age- and IQ-Matched Control Group

In the early publications on the 22q11.2 Deletion Syndrome (22q11.2DS) motor abnormalities have been frequently reported. However, systematic studies on the motor performance of children with the 22q11.2DS, and especially of school-age children, are scarce. In this study the motor performance of primary school-age children with a 22q11.2DS (n = 28) was compared with an age- and IQ-matched control group (n = 28) using the Movement Assessment Battery for Children (MABC), the Körperkoordinationstest für Kinder (KTK) and the Beery-Buctenica test of Visual-Motor Integration (Beery). Children with a 22q11.2DS scored significantly lower than the age- and IQ-matched control group on the subsection Manual Dexterity (MABC) and the Visual Perception and Motor Coordination subtests of the Beery. When investigating the correlations between Intelligence quotient (IQ) and motor performance, a specific profile was found in the 22q11.2DS group when compared with the age- and IQ-matched control group. Because an IQ-matched control group was adopted, the deficits in visual-perceptual and visuomotor integration skills cannot fully be attributed to a general developmental delay and thus may be specific for the 22q11.2DS. Future studies that investigate the specificity of the visual-perceptual problems — both on the behavioral and brain level (functional Magnetic Resonance Imaging [fMRI] and Diffusion Tensor Imaging [DTI]) — are necessary to answer this question. Nonetheless, the importance of incorporating motor functioning into the study of the neuropsychological profile of children with a 22q11.2DS has to be stressed.     

Robust anger: Recognition of deteriorated dynamic bodily emotion expressions

In two studies, the robustness of anger recognition of bodily expressions is tested. In the first study, video recordings of an actor expressing four distinct emotions (anger, despair, fear, and joy) were structurally manipulated as to image impairment and body segmentation. The results show that anger recognition is more robust than other emotions to image impairment and to body segmentation. Moreover, the study showed that arms expressing anger were more robustly recognised than arms expressing other emotions. Study 2 added face blurring as a variable to the bodily expressions and showed that it decreased accurate emotion recognition—but more for recognition of joy and despair than for anger and fear. In sum, the paper indicates the robustness of anger recognition in multileveled deteriorated bodily expressions.     

Off-Unit Activities Programming for Long-Stay Psychiatric Inpatients

The significance of program site for inpatient therapeutic activities offered to chronic patients is rarely discussed. This paper reviews experiences with the development of a facility-wide off-unit activities program in a state psychiatric center. The organizational, clinical, and administrative implications of off-unit proramming are examined in relation to on-unit treatment ractices. iecommendations are made to assist the successful introauction of off-unit programming and the identification of the most effective location for specific activities.     

Diagnosis of cognitive impairment onset in older adults based on limitations in language skills / Diagnóstico del inicio del deterioro cognitivo en mayores a partir de limitaciones en las capacidades lingüísticas

Abstract

Progressive decline in language has been described in neuropsychological studies on Alzheimer’s disease and Mild Cognitive Impairment (MCI). We investigate this decline in its early stages, as well as its manifestations and the linguistic differences between participants at risk of developing MCI and without impairment. Participants were 36 older adults, all aged over 65. They were assessed using 31 subtests grouped into eight areas: fluency, comprehension, oral expression, reading, writing, memory, perceptual organization and processing speed. Our results showed significant differences between participants at risk of developing MCI and without impairment in verbal tests but not in manipulative tests. All participants at risk of developing MCI scored lowest in these eight areas. Our findings illustrate the relevance of investigating language skills in people at risk of developing MCI. Investigating these neuropsychological changes will help design appropriate intervention programmes that affect areas with higher levels of impairment.     

钠尿肽系统与胃肠功能障碍性疾病的研究

钠尿肽(natriuretic peptides,NP)是具有生物活性的多聚肽类,以激素或神经递质形式发挥生理作用。自从在胃肠道内发现钠尿肽的免疫反应物质,钠尿肽系统与胃肠功能障碍性疾病的研究越来越受到重视,本文就钠尿肽系统在胃肠道内存在形式、作用机制及胃肠功能障碍性疾病中的作用做一综述。     

工作记忆子成分在听觉障碍儿童心算过程中的作用

采用2×2×3的混合实验设计,比较听力正常儿童和听觉障碍儿童在心算作业上的差异,考察了工作记忆子成分在听觉障碍儿童心算过程中的作用。结果表明,与听力正常儿童相比,听觉障碍儿童在高存储负载水平下的心算成绩显著降低,说明语音回路负责心算过程中的存储成分;而且听觉障碍儿童在对中央执行能力有高需求的实验条件下的作业水平并不比正常听力儿童差,说明他们的中央执行能力并没有受到损失。     

The effect of sight levels on daily stressors and coping styles

The structures of daily stressful events of visually impaired people are reported, and the effects of the sight levels of the subjects on these structures are examined. Sixty‐nine visually impaired people (22 males, 47 females) were interviewed and divided into three groups according to their sight levels. Subjects provided examples of stressful events for three coping styles (Don’t, Do by others, Do by oneself). Statistical analyses of the data indicated that the sight levels of visually impaired people are related to the structure of stressful events and coping styles.     

Use of the CAFAS to Evaluate Outcome for Youths with Severe Emotional Disturbance Served by Public Mental Health

Outcomes are reported for youths with serious emotional disturbance receiving customary services from community mental health service providers who receive state mental health funds. Various outcome indicators for the Child and Adolescent Functional Assessment Scale (CAFAS) are described, as well as a procedure for categorizing youths into client types based on the CAFAS subscale scores. The youth's intake assessment was compared to the last CAFAS evaluation that the youth received. A statistically significant reduction in mean CAFAS total score was observed for the entire sample and for each client type. In addition, the mean number of subscales on which the youth was rated as severely impaired significantly decreased for the total sample and for each client type. The proportion of youths who experienced a clinically meaningful improvement in functioning was 58.6%. For the subset of youths who were rated as severely impaired on one or more subscales at intake, 53.1% left services without any severe impairments. The pattern of outcome results differed for subgroups based on type and extent of impairment. Implications of these findings and suggestions for using outcome monitoring to improve services in the public mental health sector are discussed.     

Screening for cognitive impairment in an Australian aged care assessment team as part of comprehensive geriatric assessment

Accurate detection of mild cognitive impairment (MCI) is important to stratify and address risk. Yet, few short cognitive screening instruments are validated for this. . In Australia, all clients referred to an Aged Care Assessment Team (ACAT) receive comprehensive geriatric assessment (CGA) including the Standardized Mini-Mental State Examination (SMMSE). We compared the accuracy of the quick mild cognitive impairment (Qmci) screen to the SMMSE in 283 participants: 195 with dementia, 47 with MCI, and 41 with subjective cognitive decline (SCD) in an Australian community-based ACAT. Both had similar accuracy in identifying dementia, AUC of 0.86 for the Qmci versus 0.93 for the SMMSE (p = 0.10), but the Qmci was more accurate than the SMMSE in differentiating MCI from SCD, AUC of 0.84 versus 0.71, respectively, p = 0.046. These suggest that the new, short (3–5 min) Qmci screenis appropriate for use in an ACAT or other units conducting CGA.     

双通路理论视角下孤独症谱系障碍者的视线加工障碍

临床行为观察发现, 孤独症谱系障碍个体普遍存在不能与他人建立视线接触, 不能追随他人视线看向目标物体等视线加工(gaze processing)障碍。然而已有实验研究发现该群体在实验情境中普遍存在视线接触(eye contact)异常, 但其视线追随行为(gaze following)则存在正常与异常并存的现象。基于视线加工双通路理论的启示, 该障碍可能是由于视线加工皮下通路先天功能异常而皮层通路后天发展异常所致。然而, 该理论尚缺乏皮下通路先天功能异常是视线接触障碍潜在神经机制的直接证据, 还需进一步考察皮下通路先天功能异常对视线追随障碍的影响作用, 以及皮层通路后天发展异常即其补偿机制的神经回路及早期形成过程。