轻度认知损伤重复效应脑电研究：范式及应用

“语义一致性加重复”范式（congruity-plus-repetition paradigm）在早前重复范式的基础上增加了早期语义情境用以控制重复效应的前期成份N400和后期成份P600之间的相互干扰。作者回顾了这种范式在轻度认知损伤（mild cognitive impairment,MCI）的事件相关电位研究领域的应用,并分析了该范式在MCI的识别及预测其向痴呆转归方面的优越性。提示效应的组合更能标记正常认知老化向痴呆的动态过渡;能产生两个或多个效应组合的实验范式将是该领域未来研究方向之一。     

Associations Among Anxiety Disorders and Non-anxiety Disorders,Functional Impairment and Medication in Children and Adolescents

This is a study of comorbid anxiety disorders and how they affect the clinical picture of comorbid cases. The sample consisted of 576 Spanish children aged 8 to 17 years receiving psychiatric outpatient consultation that were evaluated using a semi-structured diagnostic interview for both parents and children. A specific association of homotypic comorbidity among anxiety disorders that was independent of the presence of other disorders was found. There was heterotypic comorbidity between anxiety and depressive disorders, ADHD, anorexia and tic disorders. Relationships between non-anxiety disorders were, in general, independent of anxiety, but anxiety moderated the relationship between ADHD-Conduct disorder and Conduct disorder-enuresis. Comorbid anxiety increased difficulties in social interaction, was related with higher global impairment and had an impact on consultation and medication. Anxiety disorder comorbidity should be well recognized in order not to disregard the treatment of all present disorders.     

Relative absence of neuropsychological deficit in patients with low grade astrocytomas

Given the current accuracy and precision of modern brain imaging technology, there is presumed to be little utility in neuropsychological assessment procedures in patients with brain tumors. The primary exposure of many clinical neuropsychologists to patients with brain tumors is during their training, in the form of didactic classroom activities, such as reviewing the brain tumor cases of early investigators in the field. Historically, these brain tumors were the more aggressive and destructive tumors, such as grade III and IV astrocytomas, that could be identified with pre CT and pre MRI technology. With current imaging technology, low grade tumors that might previously have gone undiagnosed for years can be detected and patients followed over time. This series of cases represents documentation of the very unique neuropsychological status of patients with relatively slow growing, infiltrative brain tumors classified as grade II astrocytomas. The potential relevance of neuropsychological assessment for such cases is discussed.     

Behavioral Characteristics of DSM-IV ADHD Subtypes in a School-Based Population

From an ethnically diverse sample of 2,744 school children, 221 attention deficit hyperactivity disorder (ADHD) [123 (4.5%) predominantly inattentive (IA), 47 (1.7%) predominantly hyperactive/impulsive (HI), and 51 (1.9%) combined type (C)] were identified using teacher ratings on a Diagnostic and Statistical Manual of Mental Disorders (4th ed.) (DSM-IV) symptom checklist. Subjects were compared to 221 controls on teacher ratings of behavioral, academic, and social functioning. The results revealed relatively independent areas of impairment for each diagnostic group. The IA children were impaired in all areas, but were rated as displaying more appropriate behavior and fewer externalizing problems than HI or C children. The HI group displayed externalizing and social problems, but was rated as no different than controls in learning or internalizing problems. The C group demonstrated severe and pervasive difficulties across domains. These findings support the validity of the DSM-IV ADHD subtypes; all ADHD groups demonstrated impairment relative to controls, but show different patterns of behavioral characteristics.     

Further evaluation of self and peer judgements of speech with delayed auditory feedback

Fifteen undergraduate students recorded a standard reading passage under simultaneous auditory feedback (SAF) and delayed auditory feedback (DAF, 210 ms). These pairs were rated for articulation and fluency differences, reading rate differences, pitch differences, loudness differences, and overall differences in quality of speech by the fifteen speakers and by ten peer judges. Results suggest that naive speakers under DAF form a self-impression of the effects of DAF upon their speech that is not different from the qualitative ratings of independent peer judges. The hypothesis that there was no overall difference between self and peer ratings was not rejected. Implications for the use of DAF as a research or treatment modality, or as both, are discussed.     

The early history of the behavior modification of stuttering: From laboratory to clinic

The knowledge of and attitudes toward stuttering of 152 Alabama vocational rehabilitation counselors were studied using the Alabama Rehabilitation Counselors' Attitudes Toward Stuttering (ARCATS) Inventory consisting of 25 true- false statements designed to assess knowledge of stuttering and 15 statements designed to assess attitudes toward stuttering. Counselors were found to perceive stuttering as being significantly vocationally handicapping and amenable to therapy and to perceive stutterers as almost always benefiting from therapy and as being good candidates for vocational rehabilitation. It was concluded that the vocational rehabilitation counselors studied hold attitudes facilitative to the rehabilitation of stutterers.     

Auditory processing and perceptual abilities of “organic” and “functional” stutterers

The present investigation was undertaken to determine whether significant differences in auditory processing and perceptual abilities exist between (1) stutterers as a supposedly homogeneous group when compared with controls, (2) two differentiated subgroups of stutterers, and (3) either of the stuttering subgroups when separately compared with controls. Dichotic listening and masking level difference (MLD) tasks were administered to the two groups of school-age stutterers and an age-matched nonstuttering control group. Stuttering subjects were differentiated into “organic” and “functional” subgroups on the basis of neuropsychological test performances. Organic stutterers performed significantly poorer than did controls on one MLD experimental condition. Functional stutterers performed more like control subjects than like organic stutterers.     

A case study of an English-Japanese bilingual with monolingual dyslexia

We report the case of AS, a 16 year-old English/Japanese bilingual boy, whose reading/writing difficulties are confined to English only. AS was born in Japan to a highly literate Australian father and English mother, and goes to a Japanese selective senior high school in Japan. His spoken language at home is English. AS's reading in logographic Japanese Kanji and syllabic Kana is equivalent to that of Japanese undergraduates or graduates. In contrast, his performance in various reading and writing tests in English as well as tasks involving phonological processing was very poor, even when compared to his Japanese contemporaries. Yet he has no problem with letter names or letter sounds, and his phoneme categorisation is well within the normal range of English native speakers. In order to account for our data that show a clear dissociation between AS's ability to read English and Japanese, we put forward the ‘hypothesis of granularity and transparency'. It is postulated that any language where orthography-to-phonology mapping is transparent, or even opaque, or any language whose orthographic unit representing sound is coarse (i.e. at a whole character or word level) should not produce a high incidence of developmental phonological dyslexia.