客体的视觉工作记忆研究进展

近年来,客体信息的视觉工作记忆问题引发了大量研究,并获得不少成果。本文对视觉工作记忆的研究范式,客体在视觉工作记忆中的存储方式、容量及保持时间等相关研究进行了概述,重点介绍关于视觉工作记忆存储单元和容量问题的"强客体"假设、"弱客体"假设和双重存储机制假设,并提出进一步的研究思路。     

Anomalous brain dominance and the immune system: Do left-handers have specific immunological patterns?

Geschwind and Behan (1982) and Geschwind and Galaburda (1985a, 1985b, 1985c) suggested a correlation between brain laterality and immune disorders. To test whether this hypothesis holds true not only for the frequency of immune diseases and circulating autoantibodies, but extends also to cellular immunity, we examined the association between handedness and markers of cellular immunity. Twenty-seven left-handed and 37 right-handed subjects were serologically screened for cellular parameters and 22 left-handed subjects were typed for human leukocyte antigen (HLA). When compared to the right-handers, the left-handed group showed a significant decrease in the inflammatory cell types CD3(+) T cells (total T cells), CD4(+) T cells (T-helper cells), and HLA-Dr (MHC-II, antigen-presenting cells) as well as in the CD19(+) cells (B cells) and CD16/CD57(+) cells (natural killer cells). We assume a relationship exists between cerebral hemispheric specialisation and the immune system not only for humoral but also for cellular immunity, and we discuss the role of the major histocompatibility complex in neurological and immunological development.     

A model of episodic memory: Mental time travel along encoded trajectories using grid cells

The definition of episodic memory includes the concept of mental time travel: the ability to re-experience a previously experienced trajectory through continuous dimensions of space and time, and to recall specific events or stimuli along this trajectory. Lesions of the hippocampus and entorhinal cortex impair human episodic memory function and impair rat performance in tasks that could be solved by retrieval of trajectories. Recent physiological data suggests a novel model for encoding and retrieval of trajectories, and for associating specific stimuli with specific positions along the trajectory. During encoding in the model, external input drives the activity of head direction cells. Entorhinal grid cells integrate the head direction input to update an internal representation of location, and drive hippocampal place cells. Trajectories are encoded by Hebbian modification of excitatory synaptic connections between hippocampal place cells and head direction cells driven by external action. Associations are also formed between hippocampal cells and sensory stimuli. During retrieval, a sensory input cue activates hippocampal cells that drive head direction activity via previously modified synapses. Persistent spiking of head direction cells maintains the direction and speed of the action, updating the activity of entorhinal grid cells that thereby further update place cell activity. Additional cells, termed arc length cells, provide coding of trajectory segments based on the one-dimensional arc length from the context of prior actions or states, overcoming ambiguity where the overlap of trajectory segments causes multiple head directions to be associated with one place. These mechanisms allow retrieval of complex, self-crossing trajectories as continuous curves through space and time.     

Human embryonic stem cell research and the discarded embryo argument

Many who believe that human embryos have moral status are convinced that their use in human embryonic stem cell (hESC) research can be morally justified as long as they are discarded embryos left over from fertility treatments. This is one reason why this view about discarded embryos has played such a prominent role in the debate over publicly funding hESC research in the United States and other countries. Many believe that this view offers the best chance of a compromise between the different sides in this debate. This paper focuses on what seems to be the most plausible argument for this view about discarded embryos. It shows that this argument is unsound regardless of how one understands the claim that embryos have moral status. It also discusses the implications of this conclusion for attempts to use this argument as a basis for public policy.

Looking at You or Looking Elsewhere: The Influence of Head Orientation on the Signal Value of Emotional Facial Expressions

The role of horizontal head tilt for the perceptions of emotional facial expressions was examined. For this, a total of 387 participants rated facial expressions of anger, fear, sadness, and happiness, as well as neutral expressions shown by two men and two women in either a direct or an averted face angle. Decoding accuracy, attributions of dominance and affiliation, emotional reactions of the perceivers, and the felt desire to approach the expresser were assessed. Head position was found to strongly influence reactions to anger and fear but less so for other emotions. Direct anger expressions were more accurately decoded, perceived as less affiliative, and elicited higher levels of anxiousness and repulsion, as well as less desire to approach than did averted anger expressions. Conversely, for fear expressions averted faces elicited more negative affect in the perceiver. These findings suggest that horizontal head position is an important cue for the assessment of threat.

自我参照和环境参照整合过程中的主方位判断

通过三个实验证明,自我参照和环境参照转化与整合过程中的主方位判断受拍摄方向和目标位置的影响。二者对主方位判断的作用模式不会随主方位判断任务的改变而改变,拍摄方向效表现为：朝北效应（匹配效应）和主方位效应,体现的是自我参照和环境参照整合过程中环境参照对主方位的影响;目标位置效应的认知加工时间模式可表示为：前-后轴<左-右轴<其他位置,体现的是自我参照和环境参照整合过程中自我参照对主方位的影响。本文以规范轴和规范方向为框架对数据结果进行了分析和解释。     

Detection of subtype blood cells using deep learning

Deep Learning has already shown power in many application fields, and is accepted by more and more people as a better approach than the traditional machine learning models. In particular, the implementation of deep learning algorithms, especially Convolutional Neural Networks (CNN), brings huge benefits to the medical field, where a huge number of images are to be processed and analyzed. This paper aims to develop a deep learning model to address the blood cell classification problem, which is one of the most challenging problems in blood diagnosis. A CNN-based framework is built to automatically classify the blood cell images into subtypes of the cells. Experiments are conducted on a dataset of 13k images of blood cells with their subtypes, and the results show that our proposed model provide better results in terms of evaluation parameters.     

慢性乙型肝炎T细胞功能与HBV前C区变异的研究

通过研究慢性HBV感染者前C区变异及T细胞免疫功能与疾病的相关性,评估前C（preC）区变异及T细胞免疫功能对于慢性乙型肝炎（chronichepatitisB,CHB）预后的影响。分别采用实时荧光法、突变特异PCRmsPCR法及微粒酶免疫分析法对150例HBV-DNA阳性的CHB及50例健康体检者进行血清HBV-DN...     

克服肿瘤干细胞耐药性的策略和思路

肿瘤干细胞（cancersterncells,CSCs）是肿瘤细胞的祖细胞。已有的研究表明,肿瘤干细胞对多种化疗药物具有耐药性,是导致肿瘤治疗后复发的根源。研究针对肿瘤干细胞的治疗方法,克服肿瘤干细胞耐药性,将给肿瘤治疗模式带来全新的改变,有望彻底改善肿瘤患者的预后。