噻唑烷二酮类药物在1型糖尿病治疗中的价值

噻唑烷二酮类药物（TZD）已在2型糖尿病中广泛应用。鉴于TZD具有增加胰岛素敏感性、抗炎症、调节免疫等作用,对它在1型糖尿病中的应用价值亦有探讨,这有助于指导实践和进一步研究。     

The moderating effect of parental warmth on the association between spanking and child aggression: a longitudinal approach

Using data from the Early Head Start Research and Evaluation Study, this study analysed the stability of child aggressive behaviour beginning in infancy and tested whether spanking when the child was 36 months was associated with aggressive child behaviour among three ethnic groups and whether maternal warmth moderated the effect of spanking on aggressive behaviour in each ethnic group at 36 months, after controlling for earlier aggressive behaviour. Participants included 693 Hispanic parent–child dyads, 1013 African‐American dyads and 1086 Caucasian dyads who met qualifications for participation in the Early Head Start programme. Findings suggest that infant temperament was associated with aggressive behaviour at 24 and 36 months and that child aggression remained stable. Among the three ethnic groups, spanking was only associated with aggressive behaviour for children who had Caucasian mothers and maternal warmth did not moderate the effect of spanking on aggressive behaviour. Copyright © 2009 John Wiley & Sons, Ltd.     

方向感的加工机制及影响因素

方向感是一种定位当前位置、确定前往目的地的方向及选择相应路线的能力, 与人们的日常生活和国家航空航天事业的发展有着密切联系。方向感的认知加工包括外部信息输入、内部表征建立和信息整合三个过程, 综合方向感的各加工过程的研究结果形成的方向感认知结构模型将有助于研究者全面认识其加工机制。大脑是实现方向感加工的载体, 当前对方向感神经机制的研究主要有正常人的行为实验、脑成像研究以及脑损伤病人研究三方面, 根据这三方面的研究总结得出的神经网络结构清楚地展示了方向感在大脑中的加工过程。方向感的发生和发展受到了先天遗传和后天环境的影响, 因此了解方向感的遗传基础是了解其加工机制的关键之一。遗传影像学近来取得的重大进展推动了基因、大脑和行为研究的结合, 这将是未来方向感加工机制研究的主要方向之一。     

胰腺干细胞研究中的思考

从干细胞研究发展和胰腺生理病理学研究发展两个方面,横向和纵向两个角度阐述了胰腺干细胞研究的思路,用辩证认识论和普遍联系与对立统一原理分析了胰腺干细胞研究中所面临的问题和挑战,提出应对的策略和方法,并结合胰腺干细胞发展现状,展望其应用前景。     

Parent characteristics, economic stress and neighborhood context as predictors of parent involvement in preschool children's education

This study examines factors related to three dimensions of parent involvement in preschool: school-based involvement, home-based involvement, and the parent–teacher relationship. Participants were 154 predominantly African American parents recruited from two Head Start programs. Results of bivariate and canonical correlation analyses support the validity of a multi-dimensional, ecological conceptualization of parent involvement. Perceived context variables, including economic stress and neighborhood social disorder, related negatively to parent involvement. Parent characteristics, including sense of efficacy regarding education and level of education, related positively to parent involvement. Regression analyses detected different patterns of association between predictors and the three dimensions of parent involvement. Parent characteristics were associated with home involvement, while perceived context variables were predictive of the teacher–parent relationship. Implications of differential predictors for different domains of parent involvement and directions for future research and intervention with low-income families are discussed.     

Contributions of the dorsal hippocampus and the dorsal subiculum to processing of idiothetic information and spatial memory

It is well established that the dorsal hippocampal formation is crucial for spatial memory in rats. However, little is known about the distinct functions of the dorsal hippocampus and the dorsal subiculum. To examine the role of the dorsal hippocampus and the dorsal subiculum, Long-Evans rats with excitotoxic lesions (NMDA) of the dorsal hippocampus (DH), the dorsal subiculum (DS), or both (DHDS), and controls were trained on a nonmatching-to-place task. Then, to identify the strategy used by each group, they were tested on the same task in the dark with the T-maze being rotated between the sample and the test runs. In the light, rats with combined lesions were impaired. In the dark, groups DH, DS, and controls performed near chance level except in trials without rotation, suggesting the use of a sense of direction. The same rats were trained on a radial-arm maze task. In the light, where proximal visual cues were accessible, combined lesions affected performance whereas in the dark, it was impaired by all lesions. This experiment demonstrated that the dorsal subiculum and the dorsal hippocampus play a crucial role in processing idiothetic information and/or in maintenance of this information in memory.     

Genuine eye contact elicits self-referential processing

The effect of eye contact on self-awareness was investigated with implicit measures based on the use of first-person singular pronouns in sentences. The measures were proposed to tap into self-referential processing, that is, information processing associated with self-awareness. In addition, participants filled in a questionnaire measuring explicit self-awareness. In Experiment 1, the stimulus was a video clip showing another person and, in Experiment 2, the stimulus was a live person. In both experiments, participants were divided into two groups and presented with the stimulus person either making eye contact or gazing downward, depending on the group assignment. During the task, the gaze stimulus was presented before each trial of the pronoun-selection task. Eye contact was found to increase the use of first-person pronouns, but only when participants were facing a real person, not when they were looking at a video of a person. No difference in self-reported self-awareness was found between the two gaze direction groups in either experiment. The results indicate that eye contact elicits self-referential processing, but the effect may be stronger, or possibly limited to, live interaction.     

Cumulative mild head injury (CMHI) among college rugby players: A replication and extension study

We investigated the prevalence of cumulative mild head injury (CMHI) symptoms among college student rugby players pre- and post-season. The players completed a number of neuropsychological tests known to be sensitive to CMHI effects: vocabulary, working memory, motor coordination, and a self-report Post Concussive Symptomology (PCS) checklist. A total of 18 rugby players registered at a South African university were participants (age range 18 to 24 years, SD?=?2.02 years). Data were analysed utilising Fishers Exact Test comparisons of pre- and post-season mean scores. There was significant variability on mean scores between the rugby forwards and backline players in terms of verbal memory and concept formation, cognitive flexibility, working memory, and visual motor-processing speed. Poorer overall scores from the rugby forwards may also be indicative of depression as they reported more insomnia and anger on the PCS than the backline players.     

预见性的本体论指归

囿于认识论或价值论范围,把有关预见性的一切解释置于本体论解释的视野之外,预见性的本体论根据之追究就会被无端地“搁置”起来,从而处在被“荒漠化”的境地,本体论意义之显现也就会被严实地“遮蔽”起来,即使偶有论及也只处在被“边缘化”的地带。本文由自我认识的诠解引发关于自我认识的预见性研究的本体论和方法论意义,进而集中解说自我认识何以具有预见性,自我认识的预见性有什么特点和表现形式,其存在变化是否具有客观基础暨本体论指归。     

Parallel processing across neural systems: implications for a multiple memory system hypothesis

A common conceptualization of the organization of memory systems in brain is that different types of memory are mediated by distinct neural systems. Strong support for this view comes from studies that show double (or triple) dissociations between spatial, response, and emotional memories following selective lesions of hippocampus, striatum, and the amygdala. Here, we examine the extent to which hippocampal and striatal neural activity patterns support the multiple memory systems view. A comparison is made between hippocampal and striatal neural correlates with behavior during asymptotic performance of spatial and response maze tasks. Location- (or place), movement, and reward-specific firing patterns were found in both structures regardless of the task demands. Many, but not all, place fields of hippocampal and striatal neurons were similarly affected by changes in the visual and reward context regardless of the cognitive demands. Also, many, but not all, hippocampal and striatal movement-sensitive neurons showed significant changes in their behavioral correlates after a change in visual context, irrespective of cognitive strategy. Similar partial reorganization was observed following manipulations of the reward condition for cells recorded from both structures, again regardless of task. Assuming that representations that persist across context changes reflect learned information, we make the following conclusions. First, the consistent pattern of partial reorganization supports a view that the analysis of spatial, response, and reinforcement information is accomplished via an error-driven, or match-mismatch, algorithm across neural systems. Second, task-relevant processing occurs continuously within hippocampus and striatum regardless of the cognitive demands of the task. Third, given the high degree of parallel processing across allegedly different memory systems, we propose that different neural systems may effectively compete for control of a behavioral expression system. The strength of the influence of any one neural system on behavioral output is likely modulated by factors such as motivation, experience, or hormone status.