Validation of the Preschool and Early Childhood Functional Assessment Scale (PECFAS)

Efforts to determine the prevalence of serious emotional disturbance in preschool-aged children have been hampered by the lack of a validated measure. The Preschool and Early Childhood Functional Assessment Scale (PECFAS) is a multi-dimensional measure that assesses the psychosocial functioning of children aged 3–7 years. The concurrent validity and reliability of the PECFAS were assessed in a sample of 30 preschool-aged children in a large Head Start program in Ventura, California. PECFAS ratings based on in-depth interviews were significantly related to parental ratings that the children had mental health problems, psychiatric diagnoses, teacher ratings of the child's need for mental health evaluations, teacher ratings of behavior problems on a standardized screening inventory (DIAL-R), and actual referrals for mental health evaluations. Interrater reliability for the total PECFAS score was high (r = .90) as was internal consistency of the five subscales (alpha = .86). Using the PECFAS scores as a standard, the weighted prevalence of serious emotional disturbance in this West Coast Head Start program was 17%, at the lower end of the current estimated rate of SED for older children in low income samples (18–26%).     

胚胎干细胞研究面面观

人胚胎干细胞来自具有发育成一个个体潜力的人胚胎,其研究引发了一场伦理大辩论。就胚胎干细胞的概念、人胚胎干细胞研究将带给人类的巨大效益和研究所面临需要解决的技术难题,进行了重点阐述,提出了科学技术的发展是解决伦理争议的根本手段。     

胚胎干细胞源性配子细胞的诞生对伦理学的冲击

胚胎干细胞在伦理学界引发的争论尚未平息,胚胎干细胞源性配子的诞生又在更深层次对伦理学产生了新的冲击.ESDG将在解决人类生殖问题中作出重要贡献,特别是给合法结婚的同性恋者带来了拥有带有自身遗传性状后代的希望.但是,这方面的进展势必会与伦理学产生冲突,并且有多方面的伦理问题需要人类慎重考虑.     

伦理,胚胎和干细胞研究

道德是关于规则、直觉、理解和观点的一个复杂系统。而后者影响着我们相互间处理事务的方式。它们交叉地渗入我们的道德思考。这种思维与胚胎、干细胞的伦理密切相关,因为胚胎和干细胞涉及我们对与治疗和移植组织有关的人的生命及其启始问题。就像在许多对待生命及其可以阐释的研究方法方面,要有一个道德的思辩历程一样,解决这些问题,部分地需要讨论,部分地需要回答。只有在我们认定这种讨论能够融入应用干细胞治疗的胚胎及其类源和人体组织的使用中时,我们才会清楚,大多数人体不同部位的干细胞应用是经过了对人的生命启始、我们儿童、家庭进行了思考。     

运动空间定向判断中的方向偏差及飞行惯性

模拟客体起飞和降落运动,探讨飞行场景中不同运动位置、不同意义客体和运动方向下个体运动空间定向判断能力。结果表明：(1)对降落运动轨迹的判断正确率显著低于起飞运动;(2)无意义客体偏高轨迹的判断正确率显著小于偏低轨迹,表现出方向偏差;(3)飞行场景影响方向偏差的表现形式,当飞机降落运动时,易将偏低路径判断为与预设轨迹相同,而飞机起飞运动时,易将偏高路径判断为相同,表明降落时飞机被知觉为会向斜下方越飞越低,而起飞时飞机会向斜上方越飞越高,表现出飞行惯性。结论：运动空间定向判断受到重力表征及个体知识经验等共同影响,具有认知可渗透性。     

Misconvergence to the stimulus plane causes apparent displacement of the stimulus elements seen monocularly1

Abstract: When one binocularly views a group of vertical lines through a ring, the outermost line segments (one on each side) seen within the ring are seen monocularly while the segments of the same lines outside the ring are seen binocularly. The monocular segments appear to be displaced outward with respect to the center of the ring and with respect to the corresponding binocular segments outside the ring. Three experiments examined the extent and direction of this illusory displacement as a function of viewing distance, fixation disparity created by varying the angles of the two arms of a haploscope, and fixation disparity created by a stereoscope and different Nonius stimuli. The results of the experiments confirmed the hypothesis that the apparent displacement is due to misconvergence in accordance with Wells‐Hering's laws of visual direction.     

持续性植物状态若干问题的探讨

明确意识的含义及意识障碍的分类是分析持续性植物状态的前提。根据多年临床经验对持续性植物状态的定义、评分标准、诊断与鉴别诊断进行深入割析。植物状态的研究取得相当进展,但从诊断、评分到治疗手段仍面临诸多困惑,而神经干细胞移植和神经电刺激术是未来希望所在。     

基于场景记忆的参照系整合过程中的物体方位判断

以绝对方位中的物体方位判断为实验任务,并按照以往研究把判断过程进行分解为获取目标位置信息、获取前行方向信息和判断目标物体相对于参照物体的方位信息,旨在考察不同信息获取过程下的目标位置和前行方向如何影响基于场景记忆的参照系整合过程中的绝对方位判断。实验1的判断任务同时包括这三个过程;实验2和实验3中的判断任务分别独立于路径描述（即定位后判断,先获知目标位置信息,再进行方位判断）和自身定向（即定向后判断,先获取前行方向信息,再进行方位判断）。每个任务均为目标位置（R0o－前、R45o－左前/右前、R90o－左/右、R135o－左后/右后, R180o－后）×前行方向（北、东南西、斜方向）的组内设计、因变量为正确率和判断时间为主,共有60名大学生被试（男女各半）参与实验。发现：朝北优势效应只在实验1中明显;三个实验任务中均存在正方向－左右位置优势效应、以及0o和180o位置优势效应;目标位置对物体方位判断的影响程度要大于前行方向对判断的影响程度。结合以往的研究来看,场景记忆上的判断比视觉媒介上的同类判断受目标位置影响的程度要大,其他影响模式比较一致。从判断的信息获取过程上对结果进行了讨论,这有助于理解绝对方位判断的认知结构     

Novel-view scene recognition relies on identifying spatial reference directions

Five experiments investigated whether observer locomotion provides specialized information facilitating novel-view scene recognition. Participants detected a position change after briefly viewing a desktop scene when the table stayed stationary or was rotated and when the observer stayed stationary or locomoted. The results showed that 49° novel-view scene recognition was more accurate when the novel view was caused by observer locomotion than when the novel view was caused by table rotation. However such superiority of observer locomotion disappeared when the to-be-tested viewpoint was indicated during the study phase, when the study viewing direction was indicated during the test phase, and when the novel test view was 98°, and was even reversed when the study viewing direction was indicated during the test phase in the table rotation condition but not in the observer locomotion condition. These results suggest scene recognition relies on the identification of the spatial reference directions of the scene and accurately indicating the spatial reference direction can facilitate scene recognition. The facilitative effect of locomotion occurs because the spatial reference direction of the scene is tracked during locomotion and more accurately identified at test.     

胰岛细胞移植治疗1型糖尿病现状与未来

自2000年加拿大Edmonton报道了7例1型糖尿痛患者施行胰岛细胞移植术成功以来,越来越多的人把注意力投向了胰岛细胞移植的领域。然而,临床移植工作的成功开展还面临两大困难,一方面现有的胰岛细胞来源已经远远不能满足临床移植的需要,另一方面,现有免疫抑制方案造成了很多副作用。近年来,科技工作者正在探索新的途径,寻找新的胰岛来源。特别是包括体外重编程干细胞（iPS）、调节性T细胞和脐血干细胞在内的多种新技术的研究工作取得了许多进展,将为我们提供更多的选择,有可能成为今后的发展方向。本文就胰岛细胞移植治疗1型糖尿病的现状与未来展望进行简要的综述。