中枢肥大细胞在脑功能和行为调节中的作用

已知肥大细胞作为免疫细胞在过敏反应和炎性疾病中发挥重要作用。肥大细胞在中枢亦有表达, 但对其作用了解不足。新近的研究发现中枢肥大细胞在脑功能和行为调节中发挥重要的内源性平衡作用。一方面, 中枢肥大细胞在维持相关脑区发育, 正常神经活动, 以及动机, 情绪和认知等多种行为中发挥保护性作用, 各种应激条件诱导的中枢肥大细胞表达和活动改变参与脑和行为的适应性反应过程。另一方面, 中枢肥大细胞过度激活或者过度抑制都可导致脑功能和行为异常, 并参与某些免疫相关心身疾病的病理过程。体外神经解剖学和功能学研究证据提示中枢肥大细胞与神经系统间存在结构性和功能性相互作用网络。肥大细胞和神经组织间通过形成类似突触的结构性联系直接影响相邻细胞的活动。肥大细胞还可以通过脱颗粒释放多种生物活性介质调节神经活动, 同时表达多种受体接受脑内免疫性和神经性分子调节。但是目前对于中枢肥大细胞-神经系统相互作用的认识主要基于体外研究, 其在脑内相互作用方式及其与特定脑区功能和行为表型的关系所知甚少, 开展相关研究可以为认识脑与行为的神经免疫调节机制提供新的视角。     

How does reading direction modulate perceptual asymmetry effects?

Left-side bias effects refer to a bias towards the left side of the stimulus/space in perceptual/visuospatial judgments, and are argued to reflect dominance of right hemisphere processing. It remains unclear whether reading direction can also account for the bias effect. Previous studies comparing readers of languages read from left to right with those read from right to left (e.g., French vs. Hebrew) have obtained inconsistent results. As a language that can be read from left to right or from right to left, Chinese provides a unique opportunity for a within-culture examination of reading direction effects. Chinese participants performed a perceptual judgment task (with both face and Chinese character stimuli; Experiment 1) and two visuospatial attention tasks (the greyscales and line bisection tasks; Experiment 2) once before and once after a reading task, in which they read Chinese passages either from left to right or from right to left for about 20 min. After reading from right to left, participants showed significantly reduced left-side bias in Chinese character perceptual judgments but not in the other three tasks. This effect suggests that the role of reading direction on different forms of left-side bias may differ, and its modulation may be stimulus-specific.     

骨髓间充质干细胞移植治疗对心肌梗死后心功能的影响

目前心肌梗死常规治疗不能修复已死亡或者濒死的心肌,应用干细胞替代受损或死亡的心肌细胞来改善心功能,已成为近年来国内外研究的热点。骨髓间充质干细胞通过修复坏死心肌、促进血管新生等改善心梗后心功能,其移植治疗有望成为治疗心肌梗死的一个全新方法。     

唯物辩证法在院前心肺复苏实践中的指导作用

在院前心肺复苏实践中,我们会遇到很多矛盾的问题。本文从唯物辩证法的角度出发,分析了院前心肺复苏中一些比较棘手的问题,并为解决这些问题提出建议,对从事院前急救的医学专业人士以及非医学专业人士均具有一定的启发意义。     

Observing home-visiting quality across time: A longitudinal reliability study of the Home Visit Rating Scales

Empirical examination of home-visiting quality over time is lacking in the research literature. To this end, this study examined the most recent edition of a widely used observational measure of home-visiting quality, the Home Visit Rating Scales (HOVRS), over four repeated assessments spanning an average of 6 months. Psychometric quality for the HOVRS Total and Home Visitor Practice Scales, including item ratings and calculated scores, across time was demonstrated. Stability indicators for the Family Engagement Scales varied, with superior reliability often indicated for individual ratings over the calculated score. The exploration of interrelationships among family demographics and change in HOVRS scores over time were largely insignificant. Interestingly, a decline in the Home Visitor Practice Scale significantly related to increased symptoms of maternal depression, possibly suggesting that home-visitors’ focus shifted from children's needs to those of parent s when mental health concerns were observed. Although this study is an examination of one program model and poses limited generalizability, it sets the stage for advancing the HOVRS and longitudinal measurement of home-visiting quality.     

Spatial attentional distribution is modulated by head direction during eccentric gaze

Visual perception during eccentric gaze can be facilitated when a visual stimulus appears in front of the head direction. This study investigated the relative effects of gaze location and head direction on visual perception in central and peripheral vision. Participants identified the orientation of a T-shaped figure presented in the centre of a monitor and simultaneously localised a dot appearing in the periphery, while head direction relative to gaze location was to the left, right or centre. Effects of head direction were found only when the dot appeared far from the gaze fixation point, such that dot detection was superior when it appeared to the left (right) of fixation in the left (right) head direction. Experimental results indicated this was not due to a small shift of gaze location. Thus this study suggests that head direction influences visual perception particularly in peripheral vision where visual acuity decreases.     

Modern medicine and biotechnology: an ethical conflict of interest?

When confronting the issues related to developments in modern medicine and biotechnology, we must repeatedly ask ourselves anew what can and cannot be justified in an ethical sense. For radically new ethical questions seem to arise through innovative techniques such as stem cell research or preimplantation diagnosis — and with them new areas of conflicting interests. If one scrutinizes the previous positions related to this subject, it becomes conspicuous that a multitude of questions has quickly piled up — however, (as in the case of Germany) comprehensive and differentiated views have mostly been lacking. An earlier version of this paper was presented at an International Conference on “Conflict of Interest and its Significance in Science and Medicine” held in Warsaw, Poland on 5–6 April, 2002.     

人格情绪导向模式--对H管理理论的研究

本研究从《H管理理论》的人格情绪导向模式 (心理应激——情绪——社会支持——工作行为 )的角度出发 ,探讨了该模式所包含的这几个成分之间的关系 ,我们的研究发现工作应激在该模式中起着中介的作用 ,并对工作行为具有很强的影响 ,这为实际工作情境中的管理者提供了一定的借鉴     

刍议综合性大学医学教育的发展方向

国际上一流的综合性大学都设有医学院,高水平的医学院也基本上都在综合性大学内。据此提出现阶段我国综合性大学医学教育应向研究型、国际化、现代化的方向发展,并就其发展对策提出了自己的看法。     

A LONGITUDINAL,PERSON‐CENTERED ANALYSIS OF EARLY HEAD START MOTHERS’ PARENTING

This study used a person‐centered approach to examine stability and change in parenting typologies across early childhood. Profiles were associated within and across time with contextual covariates, including demographic characteristics, risk factors, and Early Head Start participation. Participants were drawn from the Early Head Start Research and Evaluation Project (N = 2, 876). Parenting profiles were identified based on observed parenting dimensions at 14, 24, and 36 months, and pre‐Kindergarten (pre‐K). Results suggested a four‐profile solution at each time point: Supportive, Lukewarm (14 & 24 months)/Sufficient (36 months and pre‐K), Harsh, and Detached. Supportive was the largest, most stable, and most likely transitioned into profile while Harsh and Detached represented rare profiles with moderate to low membership stability across time. Depression and family conflict emerged as important correlates of unsupportive parenting profiles both within and across time. Findings are discussed in terms of their relevance for both policy and implementation practices for low‐income mothers with young children.