Neurofibromatosis Type 1 in Genetic Counseling Practice: Recommendations of the National Society of Genetic Counselors

The objective of this document is to provide recommendations for the genetic counseling of patients and families undergoing evaluation for neurofibromatosis type 1 (NF1) or who have received a diagnosis of NF1. These recommendations are the opinions of a multi-center working group of genetic counselors with expertise in the care of individuals with NF1. These recommendations are based on the committee’s clinical experiences, a review of pertinent English language medical articles, and reports of expert committees. These recommendations are not intended to dictate an exclusive course of management, nor does the use of such recommendations guarantee a particular outcome. These recommendations do not displace a health care provider’s professional judgment based on the clinical circumstances of an individual patient. Both Heather B. Radtke and Courtney D. Sebold contributed equally to this document.     

平行分析在探索性因素分析中的应用

平行分析是探索性因素分析中用来确定所保留的凶子个数的一种方法。探索性因素分析中常用的确定因子个数的方法有特征值大于1准则和碎石图,但这两种方法又各有不足。平行分析则为探索性因素分析中所保留因子个数的确定提供了另一种新思路。本文详细介绍了平行分析的步骤、潜在逻辑以及进行平行分析所用的软件,并通过实例来说明其在探索性因素分析中如何应用。     

The pop out of scene-relative object movement against retinal motion due to self-movement

An object that moves is spotted almost effortlessly; it "pops out". When the observer is stationary, a moving object is uniquely identified by retinal motion. This is not so when the observer is also moving; as the eye travels through space all scene objects change position relative to the eye producing a complicated field of retinal motion. Without the unique identifier of retinal motion an object moving relative to the scene should be difficult to locate. Using a search task, we investigated this proposition. Computer-rendered objects were moved and transformed in a manner consistent with movement of the observer. Despite the complex pattern of retinal motion, objects moving relative to the scene were found to pop out. We suggest the brain uses its sensitivity to optic flow to "stabilise" the scene, allowing the scene-relative movement of an object to be identified.     

Warren Zevon’s <Emphasis Type="Italic">The Wind</Emphasis> and Ecclesiastes: Searching for Meaning at the Threshold of Death

Telling one's story itself brings purpose to ones life, and it is an essential part of coming to grips with death. The book of Ecclesiastes and Warren Zevon’s album The Wind express the hope for social immortality rather than an actual afterlife. Both of them are suffused with a sense of death-awareness, although their location in time and place and the genre of their expressions are quite different. By looking closely at these texts, one is able to ascertain certain aspects of life review which are necessary for wholeness and completion. Hospice Chaplain CHRISTUS VNA Hospice and Palliative Care, 4415 Centerview, San Antonio, TX 78228, USA. Reverend Philip Browning Helsel is a hospice chaplain at CHRISTUS Hospice in San Antontio. He received his Master of Divinity from Princeton Theological Seminary and Clinical Pastoral Education units from Yuma Regional Medical Center in Yuma, AZ, and is an ordained minister in the Church of God (Anderson, IN). He has been a chaplain in psychiatric and general hospital settings. Past publications include articles in Pastoral Psychology and Presence, the Journal of Spiritual Directors International. He is working on a book about the life review process in literature and music, and applying for membership in the Association of Professional Chaplains.     

Mother,Melancholia, and Art in Erik H. Erikson’s <Emphasis Type="Italic">Toys and Reasons</Emphasis>

In three earlier articles (2007a, 2007b, 2007c), I focused on the theme of the relationship of melancholia and the mother, and suggested that the melancholic self may experience humor, play, and dreams as restorative resources. In this article, I want to make a similar case, based on Erik H. Erikson’s Toys and Reasons (1977), for art (in this particular case, a painting of the Annunciation). I have made a similar case for the restorative role of art in articles on Leonard da Vinci’s Mona Lisa (Capps, Pastoral Psychology, 53, 107–137, 2004) and James McNeill Whistler’s painting of his mother (Capps, Pastoral Psychology, 2007d). In the present article, however, I focus on the special biographical circumstances in Erikson’s own development of a melancholy self and the painting he discusses in Toys and Reasons, thereby suggesting that individuals may find a particular work of art especially relevant to their own experience of melancholy. I conclude with Erikson’s testimonial at the memorial service of a colleague and friend who translated her own melancholy into her service to others.

Hand function,not proximity,biases visuotactile integration later in object processing: An ERP study

Behavioral studies document a functional hand proximity effect: objects near the palm, but not the back of the hand, affect visual processing. Although visuotactile bimodal neurons integrate visual and haptic inputs, their receptive fields in monkey cortex encompass the whole hand, not just the palm. Using ERPs, we investigated whether hand function influenced the topology of integrated space around the hand. In a visual detection paradigm, target and non-target stimuli appeared equidistantly in front or in back of the hand. Equivalent N1 amplitudes were found for both conditions. P3 target versus non-target amplitude differences were greater for palm conditions. Hand proximity biased processing of visual targets equidistant from the hand early in processing. However, hand function biases emerged later when targets were selected for potential action. Thus, early hand proximity effects on object processing depend on sensory-reliant neural responses, whereas later multisensory integration depend more on the hand’s functional expertise.     

Commands as Divine Attributes

Theories of ethics that attempt to incorporate divine speech or commands as necessary elements in the construction of moral obligations are often viewed as vulnerable to a challenge based on the so‐called Euthyphro dilemma. According to this challenge, opponents of theistic ethics suppose that divine speech either informs one of a preexisting set of values and obligations, which makes it inconsequential, or is entirely arbitrary, which makes it irrational. This essay analyzes some of the debates on the nature of divine commands in eleventh‐century works of Islamic jurisprudence (u?ūl al‐fiqh). I show that Mu?tazilī jurisprudents advanced the view that divine commands were actions performed in time that had concrete manifestations, while Ash?arīs argued that divine speech in general, and commands in particular, were eternal divine attributes. After exposing certain weaknesses in the Euthyphro‐inspired objections to theistic ethics, I argue that the Ash?arī idea of commands as divine attributes is a promising move for scholars interested in defending a divine command view of moral obligation.     

Neural correlates of visuospatial consciousness in 3D default space: Insights from contralateral neglect syndrome

One of the most compelling questions still unanswered in neuroscience is how consciousness arises. In this article, we examine visual processing, the parietal lobe, and contralateral neglect syndrome as a window into consciousness and how the brain functions as the mind and we introduce a mechanism for the processing of visual information and its role in consciousness. We propose that consciousness arises from integration of information from throughout the body and brain by the thalamus and that the thalamus reimages visual and other sensory information from throughout the cortex in a default three-dimensional space in the mind. We further suggest that the thalamus generates a dynamic default three-dimensional space by integrating processed information from corticothalamic feedback loops, creating an infrastructure that may form the basis of our consciousness. Further experimental evidence is needed to examine and support this hypothesis, the role of the thalamus, and to further elucidate the mechanism of consciousness.     

PTEN、p53和BAG-1在三阴乳腺癌中的表达及意义

为了研究PTEN、p53和BAG-1在三阴乳腺癌中的表达情况及临床病理意义,并讨论三者之间的关系.采用免疫组织化学SP法检测89例三阴乳腺癌中PTEN、p53、BAG-1的表达,其阳性表达率分别为44.9％、47.2％、73.0％,三者的表达均与患者的病理组织学分级、淋巴结转移情况有关(P＜0.05).PTEN的表达与p53、BAG-1表达呈负相关;BAG-1与p53的表达呈正相关,提示三者在三阴乳腺癌中的表达存在一定关联性,临床上联合检测三者可能为TNBC预后评估、患者的个体化治疗提供一定的参考.